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  • 4',5,8-三羟基-3',6,7-三甲氧基黄酮

    Isothymonin

    4',5,8-三羟基-3',6,7-三甲氧基黄酮
    产品编号 CFN92436
    CAS编号 99615-01-7
    分子式 = 分子量 C18H16O8 = 360.3
    产品纯度 >=98%
    物理属性 Yellow cryst.
    化合物类型 Flavonoids
    植物来源 The herbs of Mentha longifolia
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4',5,8-三羟基-3',6,7-三甲氧基黄酮 CFN92436 99615-01-7 1mg QQ客服:1413575084
    4',5,8-三羟基-3',6,7-三甲氧基黄酮 CFN92436 99615-01-7 5mg QQ客服:1413575084
    4',5,8-三羟基-3',6,7-三甲氧基黄酮 CFN92436 99615-01-7 10mg QQ客服:1413575084
    4',5,8-三羟基-3',6,7-三甲氧基黄酮 CFN92436 99615-01-7 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • University of Beira Interior (Portugal)
  • National Research Council of Canada (Canada)
  • Kitasato University (Japan)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • University of Madras (India)
  • University of Fribourg (Switzerland)
  • MTT Agrifood Research Finland (Finland)
  • Universitas islam negeri Jakarta (Indonesia)
  • Chulalongkorn University (Thailand)
  • University of Hawaii Cancer Center (USA)
  • University of Amsterdam (Netherlands)
  • Chiang Mai University (Thailand)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2021, 26(9):2526.
  • Molecules.2017, 22(6)
  • Int J Mol Sci.2021, 22(16):8604.
  • Vietnam J. Chemistry2022, 60(2):211-222
  • J Med Food.2019, 22(10):1067-1077
  • The Korea Journal of Herbology2016, 29-35
  • Nat Prod Commun.2017, 12(5):771-778
  • Molecules.2021, 26(4):817.
  • J Pharmacol Sci.2021, 147(2):184-191.
  • J of Physics Conference Series2019, 1349(1)
  • Chemistry of Natural Compounds2018, 204-206
  • Life (Basel).2022, 12(12):2107.
  • Mol Microbiol.2019, 112(1):317-332
  • Biomolecules2021, 11(10),1513.
  • Pharmaceuticals (Basel).2021, 14(8):742.
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • ACS Synth Biol.2022, 11(10):3296-3304.
  • Pharmaceutics.2020, 12(9):845.
  • Mol Med Rep.2014, 9(5):1653-9
  • Front Plant Sci.2020, 10:1705
  • BMC Complement Altern Med.2019, 19(1):367
  • J of Pharmaceutical Analysis2020, doi: 10.1016
  • Phytochemistry Letters2021, 43:80-87.
  • ...
  • 生物活性
    Description: Isothymonin has antioxidant activity.It displays cyclooxygenase-1 inhibitory activity.
    Targets: COX
    In vitro:
    Phytomedicine. 2000 Mar;7(1):7-13.
    Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn.[Pubmed: 10782484]

    METHODS AND RESULTS:
    Anti-oxidant bioassay-directed extraction of the fresh leaves and stems of Ocimum sanctum and purification of the extract yielded the following compounds; cirsilineol [1], cirsimaritin [2], isothymusin [3], Isothymonin [4], apigenin [5], rosmarinic acid [6], and appreciable quantities of eugenol. The structures of compounds 1-6 were established using spectroscopic methods. Compounds 1 and 5 were isolated previously from O. sanctum whereas compounds 2 and 3 are here identified for the first time from O. sanctum. Eugenol, a major component of the volatile oil, and compounds 1, 3, 4, and 6 demonstrated good antioxidant activity at 10-microM concentrations. Anti-inflammatory activity or cyclooxygenase inhibitory activity of these compounds were observed. Eugenol demonstrated 97% cyclooxygenase-1 inhibitory activity when assayed at 1000-microM concentrations. Compounds 1, 2, and 4-6 displayed 37, 50, 37, 65, and 58% cyclooxygenase-1 inhibitory activity, respectively, when assayed at 1000-microM concentrations. Eugenol and compounds 1, 2, 5, and 6 demonstrated cyclooxygenase-2 inhibitory activity at slightly higher levels when assayed at 1000-microM concentrations.
    CONCLUSIONS:
    The activities of compounds 1-6 were comparable to ibuprofen, naproxen, and aspirin at 10-, 10-, and 1000-microM concentrations, respectively. These results support traditional uses of O. sanctum and identify the compounds responsible.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7755 mL 13.8773 mL 27.7546 mL 55.5093 mL 69.3866 mL
    5 mM 0.5551 mL 2.7755 mL 5.5509 mL 11.1019 mL 13.8773 mL
    10 mM 0.2775 mL 1.3877 mL 2.7755 mL 5.5509 mL 6.9387 mL
    50 mM 0.0555 mL 0.2775 mL 0.5551 mL 1.1102 mL 1.3877 mL
    100 mM 0.0278 mL 0.1388 mL 0.2775 mL 0.5551 mL 0.6939 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3'-羟基-5,7,4'-三甲氧基黄酮; 3'-Hydroxy-5,7,4'-trimethoxyflavone CFN95396 33554-52-8 C18H16O6 = 328.3 5mg QQ客服:2159513211
    去甲氧基矢车菊黄酮素; Desmethoxycentaureidin CFN98234 22934-99-2 C17H14O7 = 330.3 5mg QQ客服:3257982914
    半齿泽兰素; Eupatorin CFN97418 855-96-9 C18H16O7 = 344.3 10mg QQ客服:3257982914
    半齿泽兰素-5-甲醚; Eupatorin-5-methylether CFN70313 21764-09-0 C19H18O7 = 358.4 5mg QQ客服:1413575084
    金圣草(黄)素; Chrysoeriol CFN98785 491-71-4 C16H12O6 = 300.3 5mg QQ客服:215959384
    4 '-甲基金圣草素; 4'-Methylchrysoeriol CFN91826 4712-12-3 C17H14O6 = 314.3 5mg QQ客服:2159513211
    毡毛美洲茶素; Velutin CFN98290 25739-41-7 C17H14O6 = 314.3 5mg QQ客服:3257982914
    4'-Hydroxy-5,7,3'-trimethoxyflavone; 4'-Hydroxy-5,7,3'-trimethoxyflavone CFN95398 1239-68-5 C18H16O6 = 328.3 5mg QQ客服:1457312923
    棕矢车菊素; Jaceosidin CFN90386 18085-97-7 C17H14O7 = 330.29 20mg QQ客服:1457312923
    甲基条叶蓟素; 泽兰黄素; Cirsilineol CFN90418 41365-32-6 C18H16O7 = 344.32 5mg QQ客服:1457312923

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