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  • 异野漆树苷

    Isorhoifolin

    异野漆树苷
    产品编号 CFN98927
    CAS编号 552-57-8
    分子式 = 分子量 C27H30O14 = 578.5
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The leaves of Citrus paradisi.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异野漆树苷 CFN98927 552-57-8 1mg QQ客服:1413575084
    异野漆树苷 CFN98927 552-57-8 5mg QQ客服:1413575084
    异野漆树苷 CFN98927 552-57-8 10mg QQ客服:1413575084
    异野漆树苷 CFN98927 552-57-8 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Korea Institute of Oriental Medicine (Korea)
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  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Gene.2022, 815:146178.
  • J Pharm Biomed Anal.2019, 172:268-277
  • Mol Med Rep.2022, 26(4):299.
  • Food Chem.2020, 332:127412
  • Environ Toxicol.2021, 36(9):1848-1856.
  • Int J Mol Sci.2017, 18(12)
  • Molecules.2020, 25(23):5636.
  • Food Sci Biotechnol.2021, 30(2):217-226.
  • J Mol Med (Berl).2018, 96(7):661-672
  • Mol Microbiol.2019, 112(1):317-332
  • Nat Prod Sci.2016, 22(2)
  • Foods.2020, 9(10):1348.
  • Journal of Molecular Liquids2021, 334:116014.
  • Mol Med Rep.2022, 25(1):8.
  • Nat Prod Sci.2018, 24(2):109-114
  • Nat Commun.2019, 10(1):2745
  • Oxid Med Cell Longev2019, 9056845:13
  • Molecules.2017, 22(2)
  • Sci Rep.2017, 7(1):3249
  • Appl. Sci.2020, 10(20), 7323.
  • Evid Based Complement Alternat Med.2021, 2021:6687513.
  • Molecules.2019, 24(16):E2985
  • BMC Complement Altern Med.2018, 18(1):303
  • ...
  • 生物活性
    Description: Isorhoifolin and vicenin II are main compounds of ethyl acetate fraction (EAcF) obtained from Erythrina velutina leaves, EAcF increases the cardiac contractile force by increasing the l-type calcium current and activating the adrenergic receptor pathway. Isorhoifolin has antioxidant effects. It displays an anti-leakage effect comparable to or greater than diosmin. Isorhoifolin in Pilea microphylla (PM1) may reverse the disturbed metabolic milieu in C57BL/KsJ-db/db mice.
    Targets: Adrenergic Receptor
    In vitro:
    Molecules. 2013 Nov 14;18(11):14105-21.
    Chemical composition and antioxidant activity of Tánara ótó (Dracocephalum palmatum Stephan), a medicinal plant used by the North-Yakutian nomads.[Pubmed: 24241154 ]
    Dracocephalum palmatum Stephan (Lamiaceae) is a medicinal plant used by the North-Yakutian nomads.
    METHODS AND RESULTS:
    From the crude ethanolic extract of the aerial parts of this plant, 23 compounds (phenylpropanoids, coumarins, flavonoids, and triterpenes) were isolated. Among these, eight compounds (salvianolic acid B, caftaric acid, cichoric acid, umbelliferone, aesculetin, apigenin-7-O-β-D-glucuronopyranoside, Isorhoifolin, and luteolin-4'-O-β-D-glucopyranoside) were detected for the first time in the genus Dracocephalum. Their structures were elucidated based on chemical and spectral data. The levels of most of the compounds detected in the cultivated sample were close to that of the wild sample, indicating the reproducibility of the biologically active compounds of D. palmatum through cultivation.
    CONCLUSIONS:
    Investigation into the biological activity of D. palmatum under in vitro conditions demonstrated that its extracts have a strong antioxidant effect due to the presence of high concentrations of phenolic compounds.
    J Pharm Pharmacol. 2013 Jun;65(6):928-36.
    The positive inotropic effect of the ethyl acetate fraction from Erythrina velutina leaves on the mammalian myocardium: the role of adrenergic receptors.[Pubmed: 23647686 ]
    We studied the effects of ethyl acetate fraction (EAcF) obtained from Erythrina velutina leaves on mammalian myocardium.
    METHODS AND RESULTS:
    The effect of EAcF on the contractility was studied using guinea-pig left atria mounted in a tissue bath (Tyrode's solution, 29°C, 95% CO2 , 5% O2 ) and electrically stimulated (1 Hz). Concentration-response curves of EAcF were obtained in the presence of propranolol (1 μm), nifedipine (1 μm) and in reserpinized animals (5 mg/kg). The involvement of l-type calcium current (ICa,L ) on the EAcF effect was observed in cardiomyocytes of mice assessed using patch-clamp technique. EAcF (550 μg/ml) had a positive inotropic effect, increasing the atrial force by 164% (EC50  = 157 ± 44 μg/ml, n = 6), but it was less potent than isoproterenol (EC50  = 0.0036 ± 0.0019 μg/ml, n = 8). The response evoked by EAcF was abolished by propranolol or nifedipine. Reserpine did not alter the inotropic response of EAcF. Furthermore, an enhancement of the ICa,L peak (31.2%) with EAcF was observed. Chemical analysis of EAcF revealed the presence of at least 10 different flavonoid glycoside derivatives. Two were identified as vicenin II and Isorhoifolin.
    CONCLUSIONS:
    We conclude that EAcF increases the cardiac contractile force by increasing the l-type calcium current and activating the adrenergic receptor pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7286 mL 8.643 mL 17.2861 mL 34.5722 mL 43.2152 mL
    5 mM 0.3457 mL 1.7286 mL 3.4572 mL 6.9144 mL 8.643 mL
    10 mM 0.1729 mL 0.8643 mL 1.7286 mL 3.4572 mL 4.3215 mL
    50 mM 0.0346 mL 0.1729 mL 0.3457 mL 0.6914 mL 0.8643 mL
    100 mM 0.0173 mL 0.0864 mL 0.1729 mL 0.3457 mL 0.4322 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Vicinin 2; Vicinin 2 CFN95249 90456-53-4 C27H30O17 = 626.5 5mg QQ客服:3257982914
    芹菜素-4'-O-(2'',6''-二-O-E-对羟基肉桂酰)葡萄糖苷; Apigenin 4'-O-(2'',6''-di-O-E-p-coumaroyl)glucoside CFN95276 71781-79-8 C39H32O14 = 724.7 10mg QQ客服:215959384
    芹甙元-7-葡萄糖苷; Cosmosiin CFN98981 578-74-5 C21H20O10 = 432.4 20mg QQ客服:2056216494
    芹菜素7-O-(6”-O-丙二酸单酰)-β-D-葡萄糖苷; Apigenin 7-O-(6''-O-malonylglucoside) CFN95163 86546-87-4 C24H22O13 = 518.4 5mg QQ客服:1457312923
    Chamaemeloside; Chamaemeloside CFN70289 173356-77-9 C27H28O14 = 576.5 5mg QQ客服:215959384
    芹菜素-7-O-葡萄糖醛酸苷; Apigenin-7-glucuronide CFN98500 29741-09-1 C21H18O11 = 446.36 20mg QQ客服:2056216494
    芹菜素-7-O-葡萄糖醛酸甲酯苷; Apigenin 7-O-methylglucuronide CFN98894 53538-13-9 C22H20O11 = 460.4 5mg QQ客服:2056216494
    5-O-beta-D-吡喃葡萄糖苷芹菜甙元; Apigenin 5-O-beta-D-glucopyranoside CFN98352 28757-27-9 C21H20O10 = 432.4 10mg QQ客服:1457312923
    芹菜苷; Apiin CFN90165 26544-34-3 C26H28O14 = 564.49 20mg QQ客服:1457312923
    芹菜素 7-[鼠李糖-(1->2)-半乳糖醛酸苷]; Apigenin 7-[rhamnosyl-(1->2)-galacturonide] CFN95352 124167-97-1 C27H28O15 = 592.5 10mg QQ客服:2159513211

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