异鼠李素-3-葡萄糖醛酸苷

Isorhamnetin 3-glucuronide

	产品编号	CFN90568
	CAS编号	36687-76-0
	分子式 = 分子量	C₂₂H₂₀O₁₃ = 492.39
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The herbs of Potentilla discolor Bge.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
异鼠李素-3-葡萄糖醛酸苷	CFN90568	36687-76-0	1mg	QQ客服：2056216494
异鼠李素-3-葡萄糖醛酸苷	CFN90568	36687-76-0	5mg	QQ客服：2056216494
异鼠李素-3-葡萄糖醛酸苷	CFN90568	36687-76-0	10mg	QQ客服：2056216494
异鼠李素-3-葡萄糖醛酸苷	CFN90568	36687-76-0	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Uniwersytet Medyczny w ?odzi (Poland)

Biotech R&D Institute (USA)

Chulalongkorn University (Thailand)

Universidad Miguel Hernández (Spain)

University of Helsinki (Finland)

University of Wollongong (Australia)

Uniwersytet Gdański (Poland)

University of Bordeaux (France)

Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)

University of Padjajaran (Indonesia)

University of Toulouse (France)

Wageningen University (Netherlands)

Sant Gadge Baba Amravati University (India)

Universidade Federal de Santa Catarina (Brazil)

More...

Description:

Isorhamnetin 3 -O -glucuronide exerts anti-inflammatory activity by increasing heme oxygenase-1 (HO-1) expression and by suppressing Jun N-terminal kinase (JNK) and p38 signaling pathways in LPS-challenged RAW264.7 macrophage cells. Isorhamnetin 3-glucuronide can inhibit vascular cell adhesion molecule-1 (VCAM-1) cell surface expression at 2 micromol/L, indicates that it can inhibit the expression of key molecules involved in monocyte recruitment during the early stages of atherosclerosis at physiological concentrations. It (1 mg/kg i.v.) can progressively reduce mean blood pressure (MBP), measured in conscious spontaneously hypertensive rats (SHR).

Targets:

HO-1 | JNK | p38MAPK

In vivo:

Plos One, 2012, 7(3):e32673.

Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation.[Pubmed: 22427863 ]

METHODS AND RESULTS:
We have analyzed the effects on blood pressure and vascular function in vitro of the conjugated metabolites of quercetin (quercetin-3-glucuronide, Q3GA; Isorhamnetin 3-glucuronide, I3GA; and quercetin-3'-sulfate, Q3'S) in spontaneously hypertensive rats (SHR). Q3GA and I3GA (1 mg/kg i.v.), but not Q3'S, progressively reduced mean blood pressure (MBP), measured in conscious SHR. The hypotensive effect of Q3GA was abolished in SHR treated with the specific inhibitor of β-glucuronidase, saccharic acid 1,4-lactone (SAL, 10 mg/ml). In mesenteric arteries, unlike quercetin, Q3GA had no inhibitory effect in the contractile response to phenylephrine after 30 min of incubation. However, after 1 hour of incubation Q3GA strongly reduced this contractile response and this effect was prevented by SAL. Oral administration of quercetin (10 mg/Kg) induced a progressive decrease in MBP, which was also suppressed by SAL. Conjugated metabolites are involved in the in vivo antihypertensive effect of quercetin, acting as molecules for the plasmatic transport of quercetin to the target tissues.
CONCLUSIONS:
Quercetin released from its glucuronidated metabolites could be responsible for its vasorelaxant and hypotensive effect.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
鼠李亭-3-O-龙胆二糖苷; Rhamnetin 3-O-gentiobioside	CFN95835	1786990-15-8	C₂₈H₃₂O₁₇ = 640.6	5mg	QQ客服：3257982914
鼠李亭-3-O-槐糖苷; Rhamnetin 3-sophoroside	CFN95837	259234-17-8	C₂₈H₃₂O₁₇ = 640.6	5mg	QQ客服：2159513211
异鼠李素-3-葡萄糖醛酸苷; Isorhamnetin 3-glucuronide	CFN90568	36687-76-0	C₂₂H₂₀O₁₃ = 492.39	5mg	QQ客服：2159513211
异鼠李素-3-O-桑布双糖苷; Isorhamnetin 3-sambubioside	CFN95874	142059-76-5	C₂₇H₃₀O₁₆ = 610.5	5mg	QQ客服：2159513211
异鼠李素-3-O-新橙皮糖苷; Isorhamnetin-3-O-neohespeidoside	CFN99744	55033-90-4	C₂₈H₃₂O₁₆ = 624.54	20mg	QQ客服：1457312923
水仙苷; Narcissoside	CFN99773	604-80-8	C₂₈H₃₂O₁₆ = 624.54	20mg	QQ客服：2159513211
异鼠李素 3-O-葡萄糖基 (1->4)鼠李糖苷; Isorhamnetin-3-O-glucosyl-(1->4)-O-rhamnoside	CFN95723	1135753-17-1	C₂₈H₃₂O₁₆ = 624.6	5mg	QQ客服：1457312923
异鼠李亭 3-龙胆二糖甙; Astragaloside	CFN99170	17429-69-5	C₂₈H₃₂O₁₇ = 640.55	5mg	QQ客服：1413575084
异鼠李素-3,5-O-二葡萄糖苷; Isorhamnetin 3,5-O-diglucoside	CFN95488	2035413-03-5	C₂₈H₃₂O₁₇ = 640.6	10mg	QQ客服：1457312923
异鼠李素 3-O-呋喃芹菜糖 (1→2)[鼠李糖(1→6)]葡萄糖苷; Isorhamnetin 3-O-apiosyl (1->2)[rhamnosyl (1->6)]glucoside	CFN95769	165605-18-5	C₃₃H₄₀O₂₀ = 756.7	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0309 mL	10.1546 mL	20.3091 mL	40.6182 mL	50.7728 mL
5 mM	0.4062 mL	2.0309 mL	4.0618 mL	8.1236 mL	10.1546 mL
10 mM	0.2031 mL	1.0155 mL	2.0309 mL	4.0618 mL	5.0773 mL
50 mM	0.0406 mL	0.2031 mL	0.4062 mL	0.8124 mL	1.0155 mL
100 mM	0.0203 mL	0.1015 mL	0.2031 mL	0.4062 mL	0.5077 mL