异鼠李素-3-葡萄糖醛酸苷

Isorhamnetin 3-glucuronide

	产品编号	CFN90568
	CAS编号	36687-76-0
	分子式 = 分子量	C₂₂H₂₀O₁₃ = 492.39
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The herbs of Potentilla discolor Bge.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
异鼠李素-3-葡萄糖醛酸苷	CFN90568	36687-76-0	1mg	QQ客服：2056216494
异鼠李素-3-葡萄糖醛酸苷	CFN90568	36687-76-0	5mg	QQ客服：2056216494
异鼠李素-3-葡萄糖醛酸苷	CFN90568	36687-76-0	10mg	QQ客服：2056216494
异鼠李素-3-葡萄糖醛酸苷	CFN90568	36687-76-0	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Lund University (Sweden)

Chang Gung University (Taiwan)

University of Malaya (Malaysia)

Ateneo de Manila University (Philippines)

Instituto Politécnico de Bragan?a (Portugal)

University of Parma (Italy)

University of Toulouse (France)

Chinese University of Hong Kong (China)

Universidad Veracuzana (Mexico)

Ain Shams University (Egypt)

University of Hull (United Kingdom)

University of Wisconsin-Madison (USA)

University of Oslo (Norway)

Shanghai Institute of Biochemistry and Cell Biology (China)

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Description:

Isorhamnetin 3 -O -glucuronide exerts anti-inflammatory activity by increasing heme oxygenase-1 (HO-1) expression and by suppressing Jun N-terminal kinase (JNK) and p38 signaling pathways in LPS-challenged RAW264.7 macrophage cells. Isorhamnetin 3-glucuronide can inhibit vascular cell adhesion molecule-1 (VCAM-1) cell surface expression at 2 micromol/L, indicates that it can inhibit the expression of key molecules involved in monocyte recruitment during the early stages of atherosclerosis at physiological concentrations. It (1 mg/kg i.v.) can progressively reduce mean blood pressure (MBP), measured in conscious spontaneously hypertensive rats (SHR).

Targets:

HO-1 | JNK | p38MAPK

In vivo:

Plos One, 2012, 7(3):e32673.

Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation.[Pubmed: 22427863 ]

METHODS AND RESULTS:
We have analyzed the effects on blood pressure and vascular function in vitro of the conjugated metabolites of quercetin (quercetin-3-glucuronide, Q3GA; Isorhamnetin 3-glucuronide, I3GA; and quercetin-3'-sulfate, Q3'S) in spontaneously hypertensive rats (SHR). Q3GA and I3GA (1 mg/kg i.v.), but not Q3'S, progressively reduced mean blood pressure (MBP), measured in conscious SHR. The hypotensive effect of Q3GA was abolished in SHR treated with the specific inhibitor of β-glucuronidase, saccharic acid 1,4-lactone (SAL, 10 mg/ml). In mesenteric arteries, unlike quercetin, Q3GA had no inhibitory effect in the contractile response to phenylephrine after 30 min of incubation. However, after 1 hour of incubation Q3GA strongly reduced this contractile response and this effect was prevented by SAL. Oral administration of quercetin (10 mg/Kg) induced a progressive decrease in MBP, which was also suppressed by SAL. Conjugated metabolites are involved in the in vivo antihypertensive effect of quercetin, acting as molecules for the plasmatic transport of quercetin to the target tissues.
CONCLUSIONS:
Quercetin released from its glucuronidated metabolites could be responsible for its vasorelaxant and hypotensive effect.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
柽柳黄素 7-O-新橙皮糖苷; Tamarixetin 7-O-neohesperidoside	CFN91527	28283-76-3	C₂₈H₃₂O₁₆ = 624.6	5mg	QQ客服：2159513211
异鼠李素-7-O-葡萄糖苷; Isorhamnetin 7-O-glucoside	CFN91115	6743-96-0	C₂₂H₂₂O₁₂ = 478.4	5mg	QQ客服：215959384
异鼠李素-3-O-葡萄糖-7-O-鼠李糖苷; Isorhamnetin 3-glucoside-7-rhamnoside	CFN90739	17331-71-4	C₂₈H₃₂O₁₆ = 624.54	5mg	QQ客服：2056216494
异鼠李素-3,7-O-二葡萄糖苷; Isorhamnetin 3,7-O-diglucoside	CFN91130	6758-51-6	C₂₈H₃₂O₁₇ = 640.6	5mg	QQ客服：2056216494
异鼠李素-3-O-芸香苷-7-O-葡萄糖苷; Isorhamnetin-3-O-rutinoside-7-O-glucoside	CFN95494	55481-91-9	C₃₄H₄₂O₂₁ = 786.7	5mg	QQ客服：215959384
异鼠李素-3-O-β-D-葡萄糖-7-O-β-D-龙胆双糖苷; Isorhamnetin 3-O-beta-D-glucose-7-O-beta-D-gentiobioside	CFN91845	60778-00-9	C₃₄H₄₂O₂₂ = 802.7	5mg	QQ客服：1413575084
异鼠李素-3-O-槐二糖-7-O-鼠李糖苷; Isorhamnetin 3-sophoroside-7-rhamnoside	CFN90735	41328-75-0	C₃₄H₄₂O₂₁ = 786.68	5mg	QQ客服：2159513211
柠檬黄素-3-O-β-D-葡萄糖苷; Limocitrin 3-O-beta-D-glucopyranoside	CFN91697	38836-51-0	C₂₃H₂₄O₁₃ = 508.4	5mg	QQ客服：1413575084
柠檬黄素-3-O-芸香糖苷; Limocitrin-3-O-rutinoside	CFN91693	79384-27-3	C₂₉H₃₄O₁₇ = 654.6	5mg	QQ客服：215959384
柠檬黄素-3-O-槐糖苷; Limocitrin-3-O-beta-D-sophoroside	CFN91459	114882-19-8	C₂₉H₃₄O₁₈ = 670.6	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0309 mL	10.1546 mL	20.3091 mL	40.6182 mL	50.7728 mL
5 mM	0.4062 mL	2.0309 mL	4.0618 mL	8.1236 mL	10.1546 mL
10 mM	0.2031 mL	1.0155 mL	2.0309 mL	4.0618 mL	5.0773 mL
50 mM	0.0406 mL	0.2031 mL	0.4062 mL	0.8124 mL	1.0155 mL
100 mM	0.0203 mL	0.1015 mL	0.2031 mL	0.4062 mL	0.5077 mL