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  • 大尾摇碱,印度天芥莱碱

    Indicine

    大尾摇碱,印度天芥莱碱
    产品编号 CFN00283
    CAS编号 480-82-0
    分子式 = 分子量 C15H25NO5 = 299.36
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Alkaloids
    植物来源 The herbs of Heliotropium indicum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    大尾摇碱,印度天芥莱碱 CFN00283 480-82-0 1mg QQ客服:215959384
    大尾摇碱,印度天芥莱碱 CFN00283 480-82-0 5mg QQ客服:215959384
    大尾摇碱,印度天芥莱碱 CFN00283 480-82-0 10mg QQ客服:215959384
    大尾摇碱,印度天芥莱碱 CFN00283 480-82-0 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • St. Jude Children Research Hospital (USA)
  • University of Malaya (Malaysia)
  • Griffith University (Australia)
  • Max Rubner-Institut (MRI) (Germany)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • University of Fribourg (Switzerland)
  • University of Virginia (USA)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • University of Liège (Belgium)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Donald Danforth Plant Science Center (USA)
  • Helmholtz Zentrum München (Germany)
  • Utah State University (USA)
  • Monash University Sunway Campus (Malaysia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plant Direct.2021, 5(4):e00318.
  • Hum Exp Toxicol.2022, 41:9603271221143713.
  • Phytother Res.2018, 32(5):923-932
  • JOTCSA.2023, 10(4); 893-902.
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • Molecules.2019, 24(7):E1290
  • Molecules2022, 27(12):3824.
  • Journal of Third Military Medical University2018, 40(12):1073-1078
  • Processes2021, 9(5),831.
  • Food Chem Toxicol.2023, 176:113785.
  • Clin Transl Med.2021, 11(5):e392.
  • Am J Chin Med.2015, 30:1-22
  • Foods2023, 12(23), 4342.
  • Korean J of Pharmacognosy2020, 51,49-54.
  • Br J Pharmacol.2018, 175(6):902-923
  • Nutr Res Pract.2023, 17(4):670-681.
  • J Appl Biol Chem.2022, 65(4):pp.463-469.
  • Pharm Biol.2021, 59(1):134-145.
  • Antioxidants (Basel).2021, 10(3):379.
  • Food and Agriculture Org. Of the UN2019, 151-160
  • Current Topics in Nutraceutical Research2021, 19(1),p90-105.
  • Int J Mol Sci.2022, 23(24):16000.
  • J Nat Sc Biol Med2019, 10(2):149-156
  • ...
  • 生物活性
    Description: Indicine N-oxide is a more active antitumor agent than its free base Indicine.
    In vivo:
    Anim Genet. 2012 Dec;43(6):785-9.
    Variation in the XKR4 gene was significantly associated with subcutaneous rump fat thickness in indicine and composite cattle.[Pubmed: 22497494]
    Variation in the XK, Kell blood group complex subunit-related family, member 4 (XKR4) gene on BTA14 was associated with rump fat thickness in a recent genome-wide association study. This region is also of interest because it is known to show evidence of a signature of population genetic selection.
    METHODS AND RESULTS:
    In this study, additional variation in this gene was genotyped in a sample of a total of 1283 animals of the Belmont Red (BEL) and Santa Gertrudis (SGT) breeds. The SNP rs41724387 was significantly (P < 0.001) associated with rump fat thickness and explained 5.9% of the genetic variance for the trait in this sample. Using the 4466 genotypes for the SNP rs42646708 from several data sets to estimate effects in seven breeds, this relatively large quantitative trait locus effect appears to be a result of the variation in indicine and taurine-indicine composite cattle. However, the only DNA variant found in Brahman cattle that altered the predicted amino acid sequence of XKR4 was not associated with rump fat thickness.
    CONCLUSIONS:
    This suggests that causative mutations lie outside the coding sequence of this gene.
    Res Commun Chem Pathol Pharmacol. 1979 Jun;24(3):559-69.
    Relationship of the reductive metabolism of indicine N-oxide to its antitumor activity.[Pubmed: 451340]
    Several pyrrolizidine alkaloids have been demonstrated to have antitumor activity in experimental tumor systems.
    METHODS AND RESULTS:
    In general the free base form of the alkaloid exhibits greater biological activity than the corresponding N-oxide and the N-oxide must be metabolized to the base for the subsequent formation of alkylating intermediates. Indicine N-oxide is an exception in that it is a more active antitumor agent than its free base indicine.
    CONCLUSIONS:
    Studies of the antitumor activity and metabolism of indicine N-oxide, and the closely related compound, heliotrine N-oxide, given orally and intraperitoneally to mice bearing P-388 leukemia, suggest that conversion of indicine N-oxide to indicine is not essential for its antitumor activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3405 mL 16.7023 mL 33.4046 mL 66.8092 mL 83.5115 mL
    5 mM 0.6681 mL 3.3405 mL 6.6809 mL 13.3618 mL 16.7023 mL
    10 mM 0.334 mL 1.6702 mL 3.3405 mL 6.6809 mL 8.3511 mL
    50 mM 0.0668 mL 0.334 mL 0.6681 mL 1.3362 mL 1.6702 mL
    100 mM 0.0334 mL 0.167 mL 0.334 mL 0.6681 mL 0.8351 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-O-Acetylintermedine N-oxide; 7-O-Acetylintermedine N-oxide CFN00518 685132-59-6 C17H27NO7 = 357.4 5mg QQ客服:2056216494
    石松胺; Lycopsamine CFN00287 10285-07-1 C15H25NO5 = 299.37 5mg QQ客服:215959384
    7-乙酰基印美定; 7-Acetyllycopsamine CFN00288 73544-48-6 C17H27NO6 = 341.40 5mg QQ客服:2056216494
    Petasinoside; Petasinoside CFN00277 70474-34-9 C28H37NO9 = 531.60 5mg QQ客服:215959384
    Thesinine; Thesinine CFN00278 488-02-8 C17H21NO3 = 287.36 5mg QQ客服:1413575084
    Ehretinine; Ehretinine CFN00282 76231-29-3 C16H21NO3 = 275.35 5mg QQ客服:215959384
    大尾摇碱,印度天芥莱碱; Indicine CFN00283 480-82-0 C15H25NO5 = 299.36 5mg QQ客服:3257982914
    大尾摇碱-N-氧化物; Indicine N-oxide CFN00284 41708-76-3 C15H25NO6 = 315.37 5mg QQ客服:2159513211
    印美定; Intermedine CFN00285 10285-06-0 C15H25NO5 = 299.36 5mg QQ客服:2159513211
    印美定N-氧化物; Intermedine N-oxide CFN00459 95462-14-9 C15H25NO6 = 315.4 5mg QQ客服:215959384

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