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  • 丹酚酸B二甲酯

    Dimethyl lithospermate B

    丹酚酸B二甲酯
    产品编号 CFN90690
    CAS编号 875313-64-7
    分子式 = 分子量 C38H34O16 = 746.67
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The roots of Salvia miltiorrhiza Bge.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    丹酚酸B二甲酯 CFN90690 875313-64-7 10mg QQ客服:3257982914
    丹酚酸B二甲酯 CFN90690 875313-64-7 20mg QQ客服:3257982914
    丹酚酸B二甲酯 CFN90690 875313-64-7 50mg QQ客服:3257982914
    丹酚酸B二甲酯 CFN90690 875313-64-7 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Parma (Italy)
  • University of Auckland (New Zealand)
  • Lodz University of Technology (Poland)
  • Harvard University (USA)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Universidad Veracuzana (Mexico)
  • Universitas Airlangga (Indonesia)
  • St. Jude Children Research Hospital (USA)
  • Srinakharinwirot University (Thailand)
  • S.N.D.T. Women's University (India)
  • University of Mysore (India)
  • University of Madras (India)
  • University of Lodz (Poland)
  • Periyar University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korea Institute of Oriental Medicine2020, doi: 10.21203.
  • Int Immunopharmacol.2019, 71:361-371
  • J Ethnopharmacol.2023, 317:116789.
  • Molecules.2017, 22(2)
  • National Academy Science Letters2023, s40009.
  • Dicle Tip Dergisi2020, 47(2),423-430.
  • Sains Malaysiana2022, 51(4):1143-1154
  • Horticulture Research2023, uhad164.
  • Heliyon.2023, e12684.
  • Am J Chin Med.2023, 51(4):1019-1039.
  • Int J Mol Sci.2020, 21(19):7209.
  • Nutr Metab (Lond).2019, 16:31
  • In Vitro Cellular & Developmental Biology - Plant2022, 58:972-988.
  • Biochem Biophys Res Commun.2020, 527(4):889-895.
  • Molecules.2015, 20(10):19172-88
  • Kor. J. Herbol.2019, 34(2):59-66
  • Molecular & Cellular Toxicology2017, 13(3):271-278
  • J Cell Mol Med.2023, 27(11):1592-1602.
  • J Biomol Struct Dyn.2022, 5;1-17.
  • Food Sci Biotechnol.2021, 30(2):217-226.
  • Molecules2022, 27(9):2613.
  • Evidence-based Compl.&Alternative Med.2023, 5417813
  • Microchemical Journal2023. 191:108938
  • ...
  • 生物活性
    Description: Dimethyl lithospermate B is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action.Dimethyl lithospermate B slows inactivation of INa, leading to increased inward current during the early phases of the action potential (AP), might be an excellent candidate for a Na(+) channel agonist; it is effective in eliminating the arrhythmogenic substrate responsible for the Brugada syndrome and that it deserves further study as a pharmacological adjunct to implanted cardioverter/defibrillator usage.
    Targets: Calcium Channel | Sodium Channel | Potassium Channel
    In vivo:
    Circulation. 2006 Mar 21;113(11):1393-400.
    Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome.[Pubmed: 16534004]
    Dimethyl lithospermate B (dmLSB) is an extract of Danshen, a traditional Chinese herbal remedy, which slows inactivation of INa, leading to increased inward current during the early phases of the action potential (AP). We hypothesized that this action would be antiarrhythmic in the setting of Brugada syndrome.
    METHODS AND RESULTS:
    The Brugada syndrome phenotype was created in canine arterially perfused right ventricular wedge preparations with the use of either terfenadine or verapamil to inhibit INa and ICa or pinacidil to activate IK-ATP. AP recordings were simultaneously recorded from epicardial and endocardial sites together with an ECG. Terfenadine, verapamil, and pinacidil each induced all-or-none repolarization at some epicardial sites but not others, leading to ST-segment elevation as well as an increase in both epicardial and transmural dispersions of repolarization (EDR and TDR, respectively) from 12.9+/-9.6 to 107.0+/-54.8 ms and from 22.4+/-8.1 to 82.2+/-37.4 ms, respectively (P<0.05; n=9). Under these conditions, phase 2 reentry developed as the epicardial AP dome propagated from sites where it was maintained to sites at which it was lost, generating closely coupled extrasystoles and ventricular tachycardia and fibrillation. Addition of dmLSB (10 micromol/L) to the coronary perfusate restored the epicardial AP dome, reduced EDR and TDR to 12.4+/-18.1 and 24.4+/-26.7 ms, respectively (P<0.05; n=9), and abolished phase 2 reentry-induced extrasystoles and ventricular tachycardia and fibrillation in 9 of 9 preparations.
    CONCLUSIONS:
    Our data suggest that dmLSB is effective in eliminating the arrhythmogenic substrate responsible for the Brugada syndrome and that it deserves further study as a pharmacological adjunct to implanted cardioverter/defibrillator usage.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3393 mL 6.6964 mL 13.3928 mL 26.7856 mL 33.482 mL
    5 mM 0.2679 mL 1.3393 mL 2.6786 mL 5.3571 mL 6.6964 mL
    10 mM 0.1339 mL 0.6696 mL 1.3393 mL 2.6786 mL 3.3482 mL
    50 mM 0.0268 mL 0.1339 mL 0.2679 mL 0.5357 mL 0.6696 mL
    100 mM 0.0134 mL 0.067 mL 0.1339 mL 0.2679 mL 0.3348 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    丹酚酸A甲酯; Methyl salvionolate A CFN92564 1015171-69-3 C27H24O10 = 508.5 5mg QQ客服:1457312923
    异丹酚酸C; Isosalvianolic acid C CFN92565 142115-17-1 C26H20O10 = 492.4 5mg QQ客服:3257982914
    丹酚酸C; Salvianolic acid C CFN98553 115841-09-3 C26H20O10 = 492.44 20mg QQ客服:1457312923
    紫草酸; Lithospermic acid CFN98546 28831-65-4 C27H22O12 = 538.46 20mg QQ客服:1413575084
    9-紫草酸甲酯; Monomethyl lithospermate CFN91005 933054-33-2 C28H24O12 = 552.5 10mg QQ客服:1413575084
    丹参酚酸Y; Salvianolic acid Y CFN91004 1638738-76-7 C36H30O16 = 718.6 5mg QQ客服:1457312923
    丹酚酸B; Salvianolic acid B CFN99332 115939-25-8 C36H30O16 = 718.62 20mg QQ客服:2056216494
    丹参酸B 镁盐; Magnesium Lithospermate B CFN90390 122021-74-3 C36H28MgO16 = 740.90 5mg QQ客服:215959384
    9’-丹酚酸B单甲酯; 9'-Methyl lithospermate B CFN90691 1167424-31-8 C37H32O16 = 732.64 20mg QQ客服:2056216494
    9'''-丹酚酸B单甲酯; 9'''-Methyl salvianolate B CFN90810 1167424-32-9 C37H32O16 = 732.7 20mg QQ客服:1457312923

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