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  • 垂茄啶

    Demissidine

    垂茄啶
    产品编号 CFN70371
    CAS编号 474-08-8
    分子式 = 分子量 C27H45NO = 399.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The peels of Solanum tuberosum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    垂茄啶 CFN70371 474-08-8 1mg QQ客服:3257982914
    垂茄啶 CFN70371 474-08-8 5mg QQ客服:3257982914
    垂茄啶 CFN70371 474-08-8 10mg QQ客服:3257982914
    垂茄啶 CFN70371 474-08-8 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • University of Bonn (Germany)
  • University of Illinois at Chicago (USA)
  • University of Sao Paulo (Brazil)
  • University of Toulouse (France)
  • Subang Jaya Medical Centre (Malaysia)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Monash University (Australia)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Nanjing University of Chinese Medicine (China)
  • University of Medicine and Pharmacy (Romania)
  • Florida International University (USA)
  • Julius Kühn-Institut (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Asian J Beauty Cosmetol2016, 14(3):249-257
  • Chemistry of Plant Materials.2019, 129-136
  • Onco Targets Ther.2017, 10:3467-3474
  • J Biomol Struct Dyn.2022, 1-21.
  • TCI CO.2019, US20190151257A1
  • Front Cell Dev Biol.2021, 9:764263.
  • Pharmaceutics.2022, 14(3):564.
  • Int J Mol Sci.2022, 23(23):14826.
  • Separation Science Plus2022, sscp.202200048.
  • Molecules.2023, 28(3):958.
  • FASEB J.2022, 36(7):e22387.
  • Enzyme Microb Technol.2019, 122:64-73
  • Foods.2022, 11(12):1708.
  • Anal Biochem.2019, 569:10-15
  • The University of Manitoba2021, 35690.
  • Plants (Basel).2021, 10(6):1119.
  • Int J Mol Sci.2020, 21(9):3144.
  • Research Square2022, rs.3.rs-1948239
  • ACS Synth Biol.2022, 11(10):3296-3304.
  • Industrial Crops and Products2021, 163:113313.
  • Nutrients2020, 12(2):488
  • J Ethnopharmacol.2019, 244:112074
  • Phytomedicine.2022, 99:154025.
  • ...
  • 生物活性
    Description: Demissidine can induce programmed cell death.
    In vitro:
    Molecules 2008, 13(10):2462-2473.
    Alkaloids Induce Programmed Cell Death in Bloodstream Forms of Trypanosomes (Trypanosoma b. brucei).[Reference: WebLink]
    The potential induction of a programmed cell death (PCD) in Trypanosoma b. brucei by 55 alkaloids of the quinoline, quinolizidine, isoquinoline, indole, terpene, tropane, steroid, and piperidine type was studied by measuring DNA fragmentation and changes in mitochondrial membrane potential.
    METHODS AND RESULTS:
    For comparison, the induction of apoptosis by the same alkaloids in human leukemia cells (Jurkat APO-S) was tested. Several alkaloids of the isoquinoline, quinoline, indole and steroidal type (berberine, chelerythrine, emetine, sanguinarine, quinine, ajmalicine, ergotamine, harmine, vinblastine, vincristine, colchicine, chaconine, demissidine and veratridine) induced programmed cell death, whereas quinolizidine, tropane, terpene and piperidine alkaloids were mostly inactive. Effective PCD induction (EC50 below 10 µM) was caused in T. brucei by chelerythrine, emetine, sanguinarine, and chaconine.
    CONCLUSIONS:
    The active alkaloids can be characterized by their general property to inhibit protein biosynthesis, to intercalate DNA, to disturb membrane fluidity or to inhibit microtubule formation.
    Pharmaceutical biology, 2009, 47(3):255-259.
    Biological activities of steroidal alkaloids isolated from Solanum leucocarpum.[Reference: WebLink]
    The alkaloids demissidine, dihydrosolacongestidine, solasodine and tomatidine were isolated and identified by spectroscopic methods and by comparison with literature data, from the aerial part of Solanum leucocarpum Dunal (Solanaceae) collected at the Regional Natural Park Ucumarí (Colombia).
    METHODS AND RESULTS:
    In order to examine topoisomerase I and II activities, the four isolated alkaloids were tested through a mechanism-based bioassay utilizing genetically engineered mutants of yeast Saccharomyces cerevisiae strains RS322N, R52Y and RS321. Dihydrosolacongestidine showed selective activity towards RS321 (249.8 μg/mL) strain rather than RS322N (1542.7 μg/mL), most probably indicating activity through inhibition of DNA topoisomerase II. In the same manner, tomatidine displayed activity through DNA topoisomerase II inhibition. Furthermore, solasodine showed DNA-damaging activity. In addition, the same isolated alkaloids were tested for antibacterial activity by using the agar well diffusion method.
    CONCLUSIONS:
    Solasodine and dihydrosolacongestidine showed MIC values of 62.5 and 125 μg/mL against Staphylococcus aureus, respectively. The isolation of these alkaloids and their biological activities are reported here for the first time for S. leucocarpum.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5019 mL 12.5094 mL 25.0188 mL 50.0375 mL 62.5469 mL
    5 mM 0.5004 mL 2.5019 mL 5.0038 mL 10.0075 mL 12.5094 mL
    10 mM 0.2502 mL 1.2509 mL 2.5019 mL 5.0038 mL 6.2547 mL
    50 mM 0.05 mL 0.2502 mL 0.5004 mL 1.0008 mL 1.2509 mL
    100 mM 0.025 mL 0.1251 mL 0.2502 mL 0.5004 mL 0.6255 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    藜芦托素; Veratrosine CFN93067 475-00-3 C33H49NO7 = 571.75 5mg QQ客服:1457312923
    澳洲茄胺; 澳州茄胺; Solasodine CFN90200 126-17-0 C27H43NO2 = 413.62 20mg QQ客服:3257982914
    澳洲茄碱; Solasonine CFN90156 19121-58-5 C45H73NO16 = 884.06 20mg QQ客服:2056216494
    澳洲茄边碱; Solamargine CFN90159 20311-51-7 C45H73NO15 = 868.06 20mg QQ客服:3257982914
    beta-澳洲茄边碱; Khasianine CFN90387 32449-98-2 C39H63NO11 = 721.93 20mg QQ客服:2159513211
    Beta-茄边碱; Beta-Solamarine CFN90552 3671-38-3 C45H73NO15 = 868.07 5mg QQ客服:1457312923
    澳茄新碱; Solasurine CFN90553 27028-76-8 C39H63NO11 = 721.92 5mg QQ客服:1413575084
    澳洲边茄碱; Solamarine CFN93102 20318-30-3 C45H73NO16 = 884.1 5mg QQ客服:2159513211
    番茄碱苷; Tomatine CFN90930 17406-45-0 C50H83NO21 = 1034.2 20mg QQ客服:215959384
    垂茄啶; Demissidine CFN70371 474-08-8 C27H45NO = 399.7 5mg QQ客服:2056216494

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