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  • D-(-)-水杨苷; D-(-)-水杨甙

    • D-(-)-水杨苷; D-(-)-水杨甙

    D-(-)-Salicin

    D-(-)-水杨苷; D-(-)-水杨甙
    		产品编号 CFN99541
    CAS编号 138-52-3
    分子式 = 分子量 C13H18O7 = 286.27
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The peels of Salix alba L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    D-(-)-水杨苷; D-(-)-水杨甙 CFN99541 138-52-3 10mg QQ客服：2056216494
    D-(-)-水杨苷; D-(-)-水杨甙 CFN99541 138-52-3 20mg QQ客服：2056216494
    D-(-)-水杨苷; D-(-)-水杨甙 CFN99541 138-52-3 50mg QQ客服：2056216494
    D-(-)-水杨苷; D-(-)-水杨甙 CFN99541 138-52-3 100mg QQ客服：2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Istanbul University (Turkey)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Biol Rep.2024, 51(1):56.
  • Molecules.2019, 24(6):E1177
  • Phytomedicine.2021, 83:153483.
  • Chemistry of Natural Compounds2018, 54(3):572-576
  • Front Plant Sci.2021, 12:673337.
  • Int J Mol Sci.2022, 23(11):6172.
  • Planta Med.2018, 84(6-07):465-474
  • Antioxidants (Basel).2023, 12(1):189.
  • Drug Des Devel Ther.2023, 17:2461-2479.
  • J Agric Food Chem.2016, 64(35):6783-90
  • Heinrich Heine University Dusseldorf2021, 62203.
  • Earth Environ. Sci. 2021, 905:012080.
  • Sci Adv.2018, 4(10)
  • Cell Physiol Biochem.2017, 44(4):1381-1395
  • Plant Cell Physiol.2023, 64(7):716-728.
  • Int J Mol Sci.2021, 22(16):8604.
  • Food Sci Nutr.2023, 11(9):5532-5542.
  • Phytochem Anal.2013, 24(5):493-503
  • J Korean Society of Food Science & Nutrition2021, 50(9): 962-970
  • Int J Mol Sci.2023, 24(8):7045.
  • Phytother Res.2022, 35844057.
  • Chem Biol Interact.2019, 298:1-7
  • Int J Mol Sci.2018, 19(9):E2681
  • ...
    • 生物活性
    Description: D(-)-Salicin is a traditional medicine which has been known to exhibit anti-inflammation and other therapeutic activities, it can inhibit the LPS-induced inflammation in RAW264.7 cells and mouse models.
    Targets: TNF-α | MAPK | NF-kB | IL Receptor
    In vitro:
    Int Immunopharmacol. 2015 Jun;26(2):286-94.
    D(-)-Salicin inhibits the LPS-induced inflammation in RAW264.7 cells and mouse models.[Pubmed: 25907238]
    D(-)-Salicin is a traditional medicine which has been known to exhibit anti-inflammation and other therapeutic activities.
    METHODS AND RESULTS:
    The present study aimed to investigate whether D(-)-Salicin inhibited the LPS-induced inflammation in vivo and in vitro. We evaluated the effect of D(-)-Salicin on cytokines (TNF-α, IL-1β, IL-6 and IL-10) in vivo and in vitro by enzyme-linked immunosorbent assay and signaling pathways (MAPKs and NF-κB) in vivo by Western blot. The results showed that D(-)-Salicin markedly decreased TNF-α, IL-1β and IL-6 concentrations and increased IL-10 concentration. In addition, western blot analysis indicated that D(-)-Salicin suppressed the activation of MAPKs and NF-κB signaling pathways stimulated by LPS. To examine whether D(-)-Salicin ameliorated LPS-induced lung inflammation, inhibitors of MAPKs and NF-κB signaling pathways were administrated intraperitoneally to mice. Interference with specific inhibitors revealed that D(-)-Salicin-mediated cytokine suppression was through MAPKs and NF-κB pathways. In the mouse model of acute lung injury, histopathologic examination indicted that D(-)-Salicin suppressed edema induced by LPS.
    CONCLUSIONS:
    So it is suggest that D(-)-Salicin might be a potential therapeutic agent against inflammatory diseases.
    In vivo:
    Int Immunopharmacol. 2015 Jun;26(2):286-94.
    D(-)-Salicin inhibits the LPS-induced inflammation in RAW264.7 cells and mouse models.[Pubmed: 25907238]
    D(-)-Salicin is a traditional medicine which has been known to exhibit anti-inflammation and other therapeutic activities.
    METHODS AND RESULTS:
    The present study aimed to investigate whether D(-)-Salicin inhibited the LPS-induced inflammation in vivo and in vitro. We evaluated the effect of D(-)-Salicin on cytokines (TNF-α, IL-1β, IL-6 and IL-10) in vivo and in vitro by enzyme-linked immunosorbent assay and signaling pathways (MAPKs and NF-κB) in vivo by Western blot. The results showed that D(-)-Salicin markedly decreased TNF-α, IL-1β and IL-6 concentrations and increased IL-10 concentration. In addition, western blot analysis indicated that D(-)-Salicin suppressed the activation of MAPKs and NF-κB signaling pathways stimulated by LPS. To examine whether D(-)-Salicin ameliorated LPS-induced lung inflammation, inhibitors of MAPKs and NF-κB signaling pathways were administrated intraperitoneally to mice. Interference with specific inhibitors revealed that D(-)-Salicin-mediated cytokine suppression was through MAPKs and NF-κB pathways. In the mouse model of acute lung injury, histopathologic examination indicted that D(-)-Salicin suppressed edema induced by LPS.
    CONCLUSIONS:
    So it is suggest that D(-)-Salicin might be a potential therapeutic agent against inflammatory diseases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4932 mL 17.466 mL 34.9321 mL 69.8641 mL 87.3301 mL
    5 mM 0.6986 mL 3.4932 mL 6.9864 mL 13.9728 mL 17.466 mL
    10 mM 0.3493 mL 1.7466 mL 3.4932 mL 6.9864 mL 8.733 mL
    50 mM 0.0699 mL 0.3493 mL 0.6986 mL 1.3973 mL 1.7466 mL
    100 mM 0.0349 mL 0.1747 mL 0.3493 mL 0.6986 mL 0.8733 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    新化合物27; New compound 27 CFN95688 N/A C39H50O22 = 870.8 5mg QQ客服：2056216494
    高熊果酚苷; 高熊果酚甙; Homoarbutin CFN90539 25712-94-1 C13H18O7 = 286.27 10mg QQ客服：2159513211
    Isohomoarbutin; Isohomoarbutin CFN89332 25162-30-5 C13H18O7 = 286.28 10mg QQ客服：2159513211
    4-甲氧基苯基β-D-吡喃葡萄糖苷; 4-Methoxyphenyl beta-D-glucopyranoside CFN90721 6032-32-2 C13H18O7 = 286.28 5mg QQ客服：2056216494
    1-苯基乙基 beta-D-吡喃葡萄糖苷; 1-Phenylethyl beta-D-glucoside CFN95574 93199-03-2 C14H20O6 = 284.3 5mg QQ客服：2056216494
    草夹竹桃苷; Androsin CFN93252 531-28-2 C15H20O8 = 328.3 20mg QQ客服：2056216494
    葡萄糖香草醛；葡萄糖香草素; Glucovanillin CFN91540 494-08-6 C14H18O8 = 314.3 5mg QQ客服：1413575084
    苄基-β-D-葡萄糖苷; Benzyl beta-D-glucopyranoside CFN95427 4304-12-5 C13H18O6 = 270.3 10mg QQ客服：3257982914
    2-Phenylethyl-beta-glucopyranoside; 2-Phenylethyl-beta-glucopyranoside CFN95429 18997-54-1 C14H20O6 = 284.3 10mg QQ客服：1413575084
    D-(-)-水杨苷; D-(-)-水杨甙; D-(-)-Salicin CFN99541 138-52-3 C13H18O7 = 286.27 20mg QQ客服：1457312923

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