D-(-)-水杨苷; D-(-)-水杨甙

D-(-)-Salicin

	产品编号	CFN99541
	CAS编号	138-52-3
	分子式 = 分子量	C₁₃H₁₈O₇ = 286.27
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The peels of Salix alba L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
D-(-)-水杨苷; D-(-)-水杨甙	CFN99541	138-52-3	10mg	QQ客服：1457312923
D-(-)-水杨苷; D-(-)-水杨甙	CFN99541	138-52-3	20mg	QQ客服：1457312923
D-(-)-水杨苷; D-(-)-水杨甙	CFN99541	138-52-3	50mg	QQ客服：1457312923
D-(-)-水杨苷; D-(-)-水杨甙	CFN99541	138-52-3	100mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Sanford Burnham Medical Research Institute (USA)

University of Malaya (Malaysia)

Siksha O Anusandhan University (India)

Martin Luther University of Halle-Wittenberg (Germany)

Mahatma Gandhi University (India)

Hamdard University (India)

Nicolaus Copernicus Uniwersity (Poland)

Cancer Research Initatives Foundation(CARIF) (Malaysia)

Seoul National University of Science and Technology (Korea)

Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)

Chungnam National University (Korea)

Charles Sturt University (Denmark)

National Research Council of Canada (Canada)

University of Wuerzburg (Germany)

More...

Description:

D(-)-Salicin is a traditional medicine which has been known to exhibit anti-inflammation and other therapeutic activities, it can inhibit the LPS-induced inflammation in RAW264.7 cells and mouse models.

Targets:

TNF-α | MAPK | NF-kB | IL Receptor

In vitro:

Int Immunopharmacol. 2015 Jun;26(2):286-94.

D(-)-Salicin inhibits the LPS-induced inflammation in RAW264.7 cells and mouse models.[Pubmed: 25907238]

D(-)-Salicin is a traditional medicine which has been known to exhibit anti-inflammation and other therapeutic activities.
METHODS AND RESULTS:
The present study aimed to investigate whether D(-)-Salicin inhibited the LPS-induced inflammation in vivo and in vitro. We evaluated the effect of D(-)-Salicin on cytokines (TNF-α, IL-1β, IL-6 and IL-10) in vivo and in vitro by enzyme-linked immunosorbent assay and signaling pathways (MAPKs and NF-κB) in vivo by Western blot. The results showed that D(-)-Salicin markedly decreased TNF-α, IL-1β and IL-6 concentrations and increased IL-10 concentration. In addition, western blot analysis indicated that D(-)-Salicin suppressed the activation of MAPKs and NF-κB signaling pathways stimulated by LPS. To examine whether D(-)-Salicin ameliorated LPS-induced lung inflammation, inhibitors of MAPKs and NF-κB signaling pathways were administrated intraperitoneally to mice. Interference with specific inhibitors revealed that D(-)-Salicin-mediated cytokine suppression was through MAPKs and NF-κB pathways. In the mouse model of acute lung injury, histopathologic examination indicted that D(-)-Salicin suppressed edema induced by LPS.
CONCLUSIONS:
So it is suggest that D(-)-Salicin might be a potential therapeutic agent against inflammatory diseases.

In vivo:

Int Immunopharmacol. 2015 Jun;26(2):286-94.

D(-)-Salicin inhibits the LPS-induced inflammation in RAW264.7 cells and mouse models.[Pubmed: 25907238]

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Homaloside D; Homaloside D	CFN99617	149155-19-1	C₂₇H₂₈O₁₂ = 544.5	5mg	QQ客服：2159513211
2'-羟基-5'-甲氧基苯乙酮; 2'-Hydroxy-5'-methoxyacetophenone	CFN97196	705-15-7	C₉H₁₀O₃ = 166.2	20mg	QQ客服：215959384
Pyrocallianthaside A; Pyrocallianthaside A	CFN95675	1004783-55-4	C₂₆H₃₄O₁₄ = 570.6	5mg	QQ客服：1413575084
新化合物31; New compound 31	CFN95699	N/A	C₂₆H₃₄O₁₄ = 570.6	5mg	QQ客服：2056216494
新化合物32; New compound 32	CFN95700	N/A	C₃₉H₅₀O₂₁ = 854.8	5mg	QQ客服：2056216494
Pyrolaside A; Pyrolaside A	CFN95671	868632-29-5	C₂₆H₃₄O₁₄ = 570.6	10mg	QQ客服：3257982914
新化合物28; New compound 28	CFN95689	N/A	C₃₂H₄₄O₁₉ = 732.7	5mg	QQ客服：1413575084
新化合物30; New compound 30	CFN95695	N/A	C₂₆H₃₄O₁₄ = 570.6	5mg	QQ客服：2159513211
Pyrolaside B; Pyrolaside B	CFN95674	868632-32-0	C₃₉H₅₀O₂₁ = 854.8	5mg	QQ客服：1457312923
新化合物29; New compound 29	CFN95693	N/A	C₃₉H₅₀O₂₁ = 854.8	5mg	QQ客服：215959384

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.4932 mL	17.466 mL	34.9321 mL	69.8641 mL	87.3301 mL
5 mM	0.6986 mL	3.4932 mL	6.9864 mL	13.9728 mL	17.466 mL
10 mM	0.3493 mL	1.7466 mL	3.4932 mL	6.9864 mL	8.733 mL
50 mM	0.0699 mL	0.3493 mL	0.6986 mL	1.3973 mL	1.7466 mL
100 mM	0.0349 mL	0.1747 mL	0.3493 mL	0.6986 mL	0.8733 mL

D-(-)-水杨苷; D-(-)-水杨甙

D-(-)-Salicin

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