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  • Corylifol A

    Corylifol A

    Corylifol A
    产品编号 CFN92226
    CAS编号 775351-88-7
    分子式 = 分子量 C25H26O4 = 390.5
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The seeds of Psoralea corylifolia L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Corylifol A CFN92226 775351-88-7 10mg QQ客服:1413575084
    Corylifol A CFN92226 775351-88-7 20mg QQ客服:1413575084
    Corylifol A CFN92226 775351-88-7 50mg QQ客服:1413575084
    Corylifol A CFN92226 775351-88-7 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Northeast Normal University Changchun (China)
  • Uniwersytet Gdański (Poland)
  • Universidad de Antioquia (Colombia)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Universidad de Buenos Aires (Argentina)
  • Massachusetts General Hospital (USA)
  • University Medical Center Mainz (Germany)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Utah State University (USA)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Macau University of Science and Technology (China)
  • MTT Agrifood Research Finland (Finland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Cell.2018, 172(1-2):249-261
  • Bioengineering2023, 10(10), 1113.
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • Molecules.2023, 28(16):6025.
  • Allergol Immunopathol (Madr).2022, 1;50(4):23-30.
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • Food Chem Toxicol.2023, 176:113802.
  • Neurotox Res.2022, 40(6):1937-1947.
  • SBRAS2016, 12
  • Natural Product Communications2022, 7(3):1-7.
  • Plants (Basel).2021, 10(11):2317.
  • Korean J. Medicinal Crop Sci.2021, 29(6):425-433
  • J Colloid Interface Sci.2022, 622:298-308.
  • Cell Rep.2020, 32(11):108158.
  • New Zealand J. Forestry Sci.2014, 44:17
  • Int J Mol Sci.2019, 20(14):E3538
  • South African Journal of Botany2021, 142:114-123.
  • Biomed Sci Letters.2020, 26:319-326
  • Molecular & Cellular Toxicology2022, 10.1007:s13273-022-00277-3
  • Eur Rev Med Pharmacol Sci.2020, 24(9):5127-5139.
  • Nutrients.2021, 13(12):4364.
  • Molecules2022, 27(14),4462
  • Heliyon.2022, 8(12):e12031.
  • ...
  • 生物活性
    Description: Corylifol A is a naturally occurring potent inhibitor of hCE2 and UDP-glucuronosyltransferase 1A1 (UGT1A1); it could be the potential uncouplers of neuronal nitric oxide synthase-postsynaptic density protein-95. Corylifol A displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. Corylifol A has antiinflammatory activity, it shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 values of 0.81 ± 0.15 uΜ, it also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells.
    Targets: NOS | IL Receptor | STAT | UGT1A1 | hCE2
    In vitro:
    Carbohydr Res. 2017 Jun 29;446-447:61-67.
    Enzymatic synthesis of novel corylifol A glucosides via a UDP-glycosyltransferase.[Pubmed: 28528234 ]
    Corylifol A, a member of the isoflavone subclass of isoflavonoids, has long been considered to have various biological activities.
    METHODS AND RESULTS:
    Here, we sought to synthesize corylifol A glucosides by the in vitro glucosylation reaction using the UDP-glycosyltransferase YjiC from Bacillus licheniformis DSM 13, and obtained two novel glucosides: corylifol A-4',7-di-O-beta-d-glucopyranoside (1) and corylifol A-4'-O-beta-d-glucopyranoside (2). To improve the yield of the products, the reaction time, concentration of UDP-glucose, and pH of the buffer were optimized. The Michaelis constant (Km) was calculated to be 2.88 mM, and the maximal velocity (Vmax) was calculated to be 77.32 nmol/min/mg for UDP-glycosyltransferase. Meanwhile, the water-solubility of compounds 1 and 2 was approximately 27.03 and 15.13 times higher, respectively, than that of their parent compound corylifol A. Additionally, the corylifol A glycosylated products exhibited the highest stability at pH 9.6 and better temperature stability than corylifol A at 40, 60, 80 and 100 °C. In addition, cytotoxicity activity assays against three human tumor cell lines, only corylifol A showed moderate anti-proliferative activity.
    CONCLUSIONS:
    Overall, this work demonstrates that glycosylation can enhance the water solubility and stability of promising compounds, with potential for further development and application.
    J Asian Nat Prod Res. 2013;15(6):624-30.
    Cytotoxic constituents from Psoralea corylifolia.[Pubmed: 23659434 ]
    Bioassay directed isolation of the EtOAc extract from a traditional Chinese medicine Psoralea corylifolia resulted in the purification of two isoflavonoids, corylifols D (1) and E (2), along with four known ones.
    METHODS AND RESULTS:
    The structures of 1 and 2 were determined by extensive 1D and 2D NMR and MS data analyses. When tested against HepG2 and Hep3B hepatocellular carcinoma cell lines, corylifol A (4) displayed IC50 values of 4.6 and 13.5 μg/ml, respectively.
    Planta Med. 2012 Jun;78(9):903-6.
    Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation.[Pubmed: 22573369 ]
    Inhibiting interleukin-6 (IL-6) has been postulated as an effective therapy in the pathogenesis of several inflammatory diseases.
    METHODS AND RESULTS:
    In this study, seven flavonoids were isolated from the methanol extracts of Psoralea corylifolia by bioactivity-guided fractionation. The structures of bakuchiol (1), bavachinin (2), neobavaisoflavone (3), corylifol A (4), corylin (5), isobavachalcon (6), and bavachin (7) were determined by spectroscopic analysis (1H-, 13C- NMR and MS). We demonstrated that compounds 1-7 showed an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 values of 4.57 ± 0.45, 3.02 ± 0.53, 2.77 ± 0.02, 0.81 ± 0.15, 1.37 ± 0.45, 2.45 ± 0.13, and 4.89 ± 0.05 μΜ, respectively. These compounds also inhibited STAT3 phosphorylation induced by IL-6 in Hep3B cells.
    CONCLUSIONS:
    Overall, several flavonoids from P. corylifolia might be useful remedies for treating inflammatory diseases by inhibiting IL-6-induced STAT3 activation and phosphorylation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5608 mL 12.8041 mL 25.6082 mL 51.2164 mL 64.0205 mL
    5 mM 0.5122 mL 2.5608 mL 5.1216 mL 10.2433 mL 12.8041 mL
    10 mM 0.2561 mL 1.2804 mL 2.5608 mL 5.1216 mL 6.402 mL
    50 mM 0.0512 mL 0.2561 mL 0.5122 mL 1.0243 mL 1.2804 mL
    100 mM 0.0256 mL 0.128 mL 0.2561 mL 0.5122 mL 0.6402 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6,8-二异戊烯基香豌豆苷元; 6,8-Diprenylorobol CFN97705 66777-70-6 C25H26O6 = 422.48 5mg QQ客服:1457312923
    山豆根酮 B1; Euchrenone B1 CFN92668 119061-09-5 C30H34O5 = 474.6 5mg QQ客服:215959384
    3',5'-二异戊烯基金雀异黄素; 3',5'-Diprenylgenistein CFN92665 104055-80-3 C25H26O5 = 406.5 5mg QQ客服:2159513211
    鱼藤属异黄酮 B; Derrisisoflavone B CFN96046 246870-75-7 C25H26O6 = 422.5 5mg QQ客服:1413575084
    5,7,4'-三羟基-6,3'-二异戊烯基异黄酮; Lupalbigenin CFN97245 76754-24-0 C25H26O5 = 406.5 5mg QQ客服:1457312923
    异鱼藤色烯异黄酮; Isochandalone CFN97894 121747-90-8 C25H24O5 = 404.5 5mg QQ客服:215959384
    Isoerysenegalensein E; Isoerysenegalensein E CFN96071 478158-77-9 C25H26O6 = 422.5 5mg QQ客服:2159513211
    Erysenegalensein E; Erysenegalensein E CFN96072 154992-17-3 C25H26O6 = 422.48 5mg QQ客服:215959384
    6,8-二异戊烯基金雀异黄素; 6,8-Diprenylgenistein CFN97935 51225-28-6 C25H26O5 = 406.5 5mg QQ客服:1413575084
    奥沙京; Osajin CFN97917 482-53-1 C25H24O5 = 404.5 5mg QQ客服:215959384

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