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  • 菊苣苷

    • 菊苣苷

    Cichoriin

    菊苣苷
    		产品编号 CFN95196
    CAS编号 531-58-8
    分子式 = 分子量 C15H16O9 = 340.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The roots of Cichorium intybus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    菊苣苷 CFN95196 531-58-8 10mg QQ客服：215959384
    菊苣苷 CFN95196 531-58-8 20mg QQ客服：215959384
    菊苣苷 CFN95196 531-58-8 50mg QQ客服：215959384
    菊苣苷 CFN95196 531-58-8 100mg QQ客服：215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Biotech R&D Institute (USA)
  • Indian Institute of Science (India)
  • Griffith University (Australia)
  • Chinese University of Hong Kong (China)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Sri Ramachandra University (India)
  • Universita' Degli Studi Di Cagliari (Italy)
  • The Ohio State University (USA)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • University of Bordeaux (France)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • University of Queensland (Australia)
  • University of Amsterdam (Netherlands)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • The Journal of Korean Medicine2023, 44(4):26-40.
  • J-STAGE2015, 249-255
  • Univerzita Karlova2021, 20.500.11956.
  • Research Square2021, 10.21203.
  • Bio-protocol2018, 9(14):e3301
  • Molecules.2023, 28(19):6775.
  • J Nat Med.2021, doi: 10.1007.
  • Front Chem.2023, 11:1245071.
  • J Food Biochem.2019, 43(9):e12970
  • Molecules2021, 26(1),230
  • Biochem Biophys Res Commun.2020, 527(4):889-895.
  • Molecules2022, 27(12):3903.
  • Nutrients.2024, 16(7):985.
  • Sci Rep. 2017, 8207(7)
  • Nutrients.2024, 16(15):2518.
  • Molecules.2019, 24(17):E3127
  • The Journal of Animal & Plant Sciences.2020, 30(6):1366-1373
  • Pharmacol Rep.2017, 69(6):1224-1231
  • Food Bioscience2023, 53:102687
  • Oncotarget.2017, 9(3):4161-4172
  • Naunyn Schmiedebergs Arch Pharmacol.2024, 03148-x.
  • Chemistry of Natural Compounds2020, 56,423-426
  • Phytochemistry.2021, 181:112539.
  • ...
    • 生物活性
    Description: Cichoriin is a photosensitive compound, it could be used as herbal photosensitizing agent in treating benign breast tumor in rats.
    In vitro:
    International Journal of Biological Chemistry, 2009, 3(1):11-17.
    Cytoprotective Activity of Chemical Constituents Isolated from Streptomyces sp.[Reference: WebLink]

    METHODS AND RESULTS:
    Four flavonoids including kaempferol (1), isoscutellarin (2), umbelliferone (3) and cichoriin (4) have been isolated from Streptomyces sp. Tc052, an endophyte in the root tissue of Alpinia galanga Swartz. The evaluation for protective effect of compounds 1-4 against glutamate-induced cytotoxicity in hippocampal HT22 cell line was conducted, Compounds 1 and 2 showed significant effective protection ratios of 62.4+2.8 and 55.3+3.4%, respectively, at a concentration of 100 μM, whereas compounds 3-4 were inactive. Compounds 1 and 2 showed potent scavenging effects on DPPH radical exhibiting IC50 value of 60.74 and 75.65 μM, respectively.
    CONCLUSIONS:
    These results suggest that compounds 1 and 2 may possess the neuroprotective activity against oxdative cellular injuries.
    In vivo:
    Electromagn Biol Med. 2012 Dec;31(4):299-309.
    Introducing Cichorium Pumilum as a potential therapeutical agent against drug-induced benign breast tumor in rats.[Pubmed: 22812448]
    Cichorium Pumilum (chicory) is could be a promising cancer treatment in which a photosensitizing drug concentrates in benign tumor cells and activated by quanta at certain wavelength. Such activated extracts could lead to cell death and tumor ablation. Previous studies have shown that Cichorium Pumilum (chicory) contains photosensitive compounds such as cichoriin, anthocyanins, lactucin, and Lactucopicrin.
    METHODS AND RESULTS:
    In the present study, the protective effect of sun light-activated Cichorium against the dimethylbenz[a]anthracene (DMBA) induced benign breast tumors to female Sprague-Dawley rats was investigated. Chicory's extract has significantly increase P.carbonyl (PC) and malondialdehyde (MDA) and decreases the hepatic levels of total antioxidant capacity (TAC) and superoxide dismutase (SOD) in benign breast tumors-induced group compared to control. It also significantly decrease the number of estrogen receptors ER-positive cells in tumor masses.
    CONCLUSIONS:
    These results suggest that chicory extracts could be used as herbal photosensitizing agent in treating benign breast tumor in rats.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9386 mL 14.6929 mL 29.3858 mL 58.7717 mL 73.4646 mL
    5 mM 0.5877 mL 2.9386 mL 5.8772 mL 11.7543 mL 14.6929 mL
    10 mM 0.2939 mL 1.4693 mL 2.9386 mL 5.8772 mL 7.3465 mL
    50 mM 0.0588 mL 0.2939 mL 0.5877 mL 1.1754 mL 1.4693 mL
    100 mM 0.0294 mL 0.1469 mL 0.2939 mL 0.5877 mL 0.7346 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    瑞香素-7-甲醚; Daphnetin 7-methyl ether CFN90593 19492-03-6 C10H8O4 = 192.17 20mg QQ客服：215959384
    7-羟基-8-甲氧基香豆素; Hydrangetin CFN89148 485-90-5 C10H8O4 = 192.17 5mg QQ客服：1413575084
    瑞香素二甲醚; Daphnetin dimethyl ether CFN90594 2445-80-9 C11H10O4 = 206.19 20mg QQ客服：1457312923
    4-甲基瑞香素; 4-Methyldaphnetin CFN93089 2107-77-9 C10H8O4 = 192.17 5mg QQ客服：1457312923
    4-甲基瑞香素 7-甲基醚; 7-Methoxy-8-hydroxy-4-methylcoumarin CFN91402 22084-94-2 C11H10O4 = 206.2 5mg QQ客服：215959384
    5,7-二羟基-4-甲基香豆素; 5,7-Dihydroxy-4-methylcoumarin CFN93090 2107-76-8 C10H8O4 = 192.17 5mg QQ客服：1413575084
    6,7-二羟基香豆素; 6,7-Dihydroxycoumarin CFN99115 305-01-1 C9H6O4 = 178.14 20mg QQ客服：2056216494
    4-甲基七叶亭; 4-Methylesculetin CFN93058 529-84-0 C10H8O4 = 192.17 5mg QQ客服：1413575084
    秦皮甲素; Esculin CFN99114 531-75-9 C15H16O9 = 340.28 20mg QQ客服：2056216494
    异莨菪亭; Isoscopoletin CFN97684 776-86-3 C10H8O4 = 192.17 20mg QQ客服：2056216494

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