7-去甲基银杏双黄酮

Bilobetin

	产品编号	CFN98846
	CAS编号	521-32-4
	分子式 = 分子量	C₃₁H₂₀O₁₀ = 552.5
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Flavonoids
	植物来源	The leaves of Ginkgo biloba L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
7-去甲基银杏双黄酮	CFN98846	521-32-4	10mg	QQ客服：2159513211
7-去甲基银杏双黄酮	CFN98846	521-32-4	20mg	QQ客服：2159513211
7-去甲基银杏双黄酮	CFN98846	521-32-4	50mg	QQ客服：2159513211
7-去甲基银杏双黄酮	CFN98846	521-32-4	100mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Pennsylvania State University (USA)

University of Sao Paulo (Brazil)

Universidade Federal de Goias (UFG) (Brazil)

National Hellenic Research Foundation (Greece)

Mendel University in Brno (Czech Republic)

Universidade da Beira Interior (Germany)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

Universiti Malaysia Pahang (Malaysia)

Northeast Normal University Changchun (China)

Kyung Hee University (Korea)

John Innes Centre (United Kingdom)

Center for protein Engineering (CIP) (Belgium)

Charles Sturt University (Denmark)

Universidade de Franca (Brazil)

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Description:

Bilobetin treatment ameliorates hyperlipidaemia, lipotoxicity and insulin resistance in rats by stimulating PPARα-mediated lipid catabolism.

Targets:

PPAR | cAMP

In vivo:

Br J Pharmacol. 2012 Apr;165(8):2692-706.

Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.[Pubmed: 22091731]

The amelioration of insulin resistance by bilobetin is closely related to its hypolipidaemic effect. The aim of the present study was to determine the insulin-sensitizing mechanism of bilobetin by elucidating its effect on lipid metabolism.
METHODS AND RESULTS:
Rats fed a high-fat diet were treated with bilobetin for either 4 or 14 days before applying a hyperinsulinaemic-euglycaemic clamp. Triglyceride and fatty acids labelled with radioactive isotopes were used to track the transportation and the fate of lipids in tissues. The activity of lipid metabolism-related enzymes and β-oxidation rate were measured. Western blot was used to investigate the phosphorylation, translocation and expression of PPARα in several tissues and cultured cells. The location of amino acid residues subjected to phosphorylation in PPARα was also studied. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity. Threonine-129-alanine and/or serine-163-alanine mutations on the PPARα genes and PKA inhibitors prevented the effects of bilobetin on PPARα. However, cells overexpressing PKA appeared to stimulate the phosphorylation, nuclear translocation and activity of PPARα.
CONCLUSIONS:
Bilobetin treatment ameliorates hyperlipidaemia, lipotoxicity and insulin resistance in rats by stimulating PPARα-mediated lipid catabolism. PKA activation is crucial for this process.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
7-去甲基银杏双黄酮; Bilobetin	CFN98846	521-32-4	C₃₁H₂₀O₁₀ = 552.5	20mg	QQ客服：2159513211
红杉双黄酮; Sequoiaflavone	CFN95642	21763-71-3	C₃₁H₂₀O₁₀ = 552.5	5mg	QQ客服：2159513211
苏铁双黄酮; Sotetsuflavone	CFN93257	2608-21-1	C₃₁H₂₀O₁₀ = 552.5	5mg	QQ客服：2159513211
银杏素; Ginkgetin	CFN90173	481-46-9	C₃₂H₂₂O₁₀ = 566.51	20mg	QQ客服：215959384
罗汉松黄酮A; Podocarpusflavone A	CFN98202	22136-74-9	C₃₁H₂₀O₁₀ = 552.5	5mg	QQ客服：2159513211
竹柏双黄酮B; Putraflavone	CFN98246	23624-21-7	C₃₂H₂₂O₁₀ = 566.5	5mg	QQ客服：215959384
三叶橡胶黄酮; Heveaflavone	CFN98236	23132-13-0	C₃₃H₂₄O₁₀ = 580.6	5mg	QQ客服：2056216494
异银杏双黄酮; Isoginkgetin	CFN90174	548-19-6	C₃₂H₂₂O₁₀ = 566.51	20mg	QQ客服：1457312923
金松双黄酮; Sciadopitysin	CFN98847	521-34-6	C₃₃H₂₄O₁₀ = 580.6	20mg	QQ客服：1457312923
7''-O-甲氧基金松双黄酮; 7''-O-Methylsciadopitysin	CFN96118	3778-25-4	C₃₄H₂₆O₁₀ = 594.6	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.81 mL	9.0498 mL	18.0995 mL	36.1991 mL	45.2489 mL
5 mM	0.362 mL	1.81 mL	3.6199 mL	7.2398 mL	9.0498 mL
10 mM	0.181 mL	0.905 mL	1.81 mL	3.6199 mL	4.5249 mL
50 mM	0.0362 mL	0.181 mL	0.362 mL	0.724 mL	0.905 mL
100 mM	0.0181 mL	0.0905 mL	0.181 mL	0.362 mL	0.4525 mL