贝韦立马

Bevirimat

	产品编号	CFN93106
	CAS编号	174022-42-5
	分子式 = 分子量	C₃₆H₅₆O₆ = 584.83
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The herbs of Ziziphus jujuba
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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贝韦立马	CFN93106	174022-42-5	1mg	QQ客服：215959384
贝韦立马	CFN93106	174022-42-5	5mg	QQ客服：215959384
贝韦立马	CFN93106	174022-42-5	10mg	QQ客服：215959384
贝韦立马	CFN93106	174022-42-5	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of East Anglia (United Kingdom)

Warszawski Uniwersytet Medyczny (Poland)

China Medical University (Taiwan)

Universidade Católica Portuguesa (Portugal)

University of Medicine and Pharmacy (Romania)

Regional Crop Research Institute (Korea)

Universidad de La Salle (Mexico)

St. Jude Children Research Hospital (USA)

National Cancer Center Research Institute (Japan)

Mendel University in Brno (Czech Republic)

Pennsylvania State University (USA)

Universidade do Porto (Portugal)

Mahatma Gandhi University (India)

Universite Libre de Bruxelles (Belgium)

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Description:

Bevirimat is a HIV-1 maturation inhibitor.

Targets:

HIV

In vivo:

Antimicrob Agents Chemother. 2007 Sep;51(9):3063-6.

Safety and pharmacokinetics of Bevirimat (PA-457), a novel inhibitor of human immunodeficiency virus maturation, in healthy volunteers.[Pubmed: 17576843 ]

Bevirimat (BVM; formerly known as PA-457) is a novel inhibitor of human immunodeficiency virus (HIV) maturation that is being developed for the treatment of HIV infection.
METHODS AND RESULTS:
The pharmacokinetics of this agent in healthy male volunteers were studied in a randomized, double-blind study in which the participants received single oral doses of placebo (n = 8) or escalating doses of BVM at 25, 50, 100, or 250 mg (n = 6 per dose); escalation was performed only after the pharmacokinetics and safety of the preceding dose had been evaluated. Plasma was collected over 480 h after dosing and urine was collected over 48 h after dosing for determination of the values of pharmacokinetic parameters. BVM was well absorbed after oral administration, with peak plasma concentrations being achieved 1 to 3 h after dosing. The half-life was 60 to 80 h. The exposure assessed by determination of the peak concentration and the area under the concentration-time curve was dose proportional. Single oral doses of BVM were well tolerated: there were no dose-limiting toxicities, and no serious adverse events were reported.
CONCLUSIONS:
These findings suggest that that BVM offers a favorable pharmacokinetic profile, with predictable pharmacokinetics following the oral administration of single doses. The long half-life of BVM may facilitate once-daily dosing.

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Suffruticosol B; Suffruticosol B	CFN95779	220936-87-8	C₄₂H₃₂O₉ = 680.7	5mg	QQ客服：1413575084
3',4',7-三甲氧基黄烷; 3',4',7-Trimethoxyflavan	CFN99264	116384-26-0	C₁₈H₂₀O₄ = 300.4	5mg	QQ客服：3257982914
Isoretronecanol; Isoretronecanol	CFN00281	526-63-6	C₈H₁₅NO = 141.21	5mg	QQ客服：215959384
D-阿拉伯糖; D-Arabinose	CFN93003	10323-20-3	C₅H₁₀O₅ = 150.1	20mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7099 mL	8.5495 mL	17.099 mL	34.198 mL	42.7475 mL
5 mM	0.342 mL	1.7099 mL	3.4198 mL	6.8396 mL	8.5495 mL
10 mM	0.171 mL	0.8549 mL	1.7099 mL	3.4198 mL	4.2747 mL
50 mM	0.0342 mL	0.171 mL	0.342 mL	0.684 mL	0.8549 mL
100 mM	0.0171 mL	0.0855 mL	0.171 mL	0.342 mL	0.4275 mL