5-甲氧基黄烷酮

5-Methoxyflavanone

	产品编号	CFN70411
	CAS编号	55947-36-9
	分子式 = 分子量	C₁₆H₁₄O₃ = 254.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The metabolite of 5-Methoxyflavone when fermented with Beauveria bassiana.
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产品名称	产品编号	CAS编号	包装	QQ客服
5-甲氧基黄烷酮	CFN70411	55947-36-9	1mg	QQ客服：2056216494
5-甲氧基黄烷酮	CFN70411	55947-36-9	5mg	QQ客服：2056216494
5-甲氧基黄烷酮	CFN70411	55947-36-9	10mg	QQ客服：2056216494
5-甲氧基黄烷酮	CFN70411	55947-36-9	20mg	QQ客服：2056216494

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Description:

5-Methoxyflavone shows antioxidant and suppressive activity on the production of nitric oxide (NO) from lipopolysaccharide (LPS)-induced macrophage cells. It provides gastroprotection against nonsteroidal anti-inflammatory drug-induced gastric damage. 5-Methoxyflavanone induces cell cycle arrest at the G2/M phase, apoptosis and autophagy in HCT116 human colon cancer cells.

Targets:

NO | p53 | Caspase | Chk2 | ERK | Autophagy | MEK | ATM

In vitro:

Food Bioscience, 2015,11(5):1-7.

In-vitro evaluation for antioxidant and anti-inflammatory property of flavanone derivatives.[Reference: WebLink]

The purpose of this study is to evaluate the antioxidant and suppressive activity of flavanone derivatives on the production of nitric oxide (NO) from lipopolysaccharide (LPS)-induced macrophage cells.
METHODS AND RESULTS:
Flavanone derivatives were prepared by adding one to three methoxy substituents (–OCH3) to flavanone or chloroflavanone structure. 5-Methoxyflavanones, including 5-methoxyflavanone, 5-methoxy-4′-chloroflavanone, and 5,4′-dimethoxyflavanone, had the best antioxidant activity, as compared to other flavanone derivatives. Anti-inflammatory effect of flavanone derivatives was studied by suppressive activity on NO synthesis from LPS-stimulated macrophages cells. 3′,4′-Dimethoxyflavanone, 5-methoxyflavanone, and 5-methoxy-4′-chloroflavanone showed the potent inhibitory activity on nitrite production. Addition of the methoxy group at 5′-position and 3′,4′-position of flavanone showed a high inhibitory activity of NO production from LPS-macrophage cells, which is one of the typical anti-inflammatory biomarkers.
CONCLUSIONS:
Taken together, the location of the methoxy group in a flavanone structure might have some connection with antioxidant and anti-inflammatory activities.

In vivo:

Digestion, 1997, 58(2):147-154.

Flavonoid-lnduced Gastroprotection in Rats: Role of Blood Flow and Leukocyte Adherence.[Reference: WebLink]

To elucidate the mechanisms of flavonoid-induced protection against nonsteroidal anti-inflammatory drug (indomethacin)-induced acute gastric damage, the effects of 5-methoxyflavone and 5-methoxyflavanone on the gastric vasculature were compared both in vivo (using laser Doppler flowmetry in anesthetized rats) and in vitro on rat superior mesenteric arteries.
METHODS AND RESULTS:
The effects of the compounds on indomethacin-induced leukocyte adherence to mesenteric venules were investigated by intravital videomicroscopy. Oral 5-methoxyflavone reduced indomethacin-induced macroscopic damage by 38 to 99% (ED50 = 5.5 mg/kg). Damage was not significantly reduced by 5-methoxyflavanone. Light microscopy studies also demonstrated a reduction in damage severity. 5-Methoxyflavone, but not 5-methoxyflavanone, increased the gastric conductance significantly. The effects on isolated mesenteric arteries correlated with the effects on in vivo conductance. Finally, indomethacin-induced leukocyte adherence was inhibited to a greater extent by 5-methoxyflavone than by 5-methoxyflavanone.
CONCLUSIONS:
In conclusion, the flavonoid 5-methoxyflavone provides gastroprotection against nonsteroidal anti-inflammatory drug-induced gastric damage. A structurally similar compound, 5-methoxyflavanone, demonstrated minimal gastroprotective activity, suggesting that the double bond of 5-methoxyflavone is required for biological activity. The finding that 5-methoxyflavone (but not 5-methoxyflavanone) significantly increased gastric vascular perfusion and reduced leukocyte adherence to mesenteric venules suggests that these mechanisms may contribute to the flavonoid's gastroprotective activity.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.9324 mL	19.6618 mL	39.3236 mL	78.6473 mL	98.3091 mL
5 mM	0.7865 mL	3.9324 mL	7.8647 mL	15.7295 mL	19.6618 mL
10 mM	0.3932 mL	1.9662 mL	3.9324 mL	7.8647 mL	9.8309 mL
50 mM	0.0786 mL	0.3932 mL	0.7865 mL	1.5729 mL	1.9662 mL
100 mM	0.0393 mL	0.1966 mL	0.3932 mL	0.7865 mL	0.9831 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
PYR-41; PYR-41	CFN60339	418805-02-4	C₁₇H₁₃N₃O₇ = 371.3	5mg	QQ客服：215959384
2'-羟基黄烷酮; 2'-Hydroxyflavanone	CFN70075	17348-76-4	C₁₅H₁₂O₃ = 240.2	20mg	QQ客服：1457312923
王百合苷C; Regaloside C	CFN91843	117591-85-2	C₁₈H₂₄O₁₁ = 416.4	10mg	QQ客服：2056216494
甲氧基丁香酚-4-O-芸香糖苷; Methoxyeugenol 4-O-rutinoside	CFN91764	903519-86-8	C₂₃H₃₄O₁₂ = 502.51	5mg	QQ客服：2159513211

5-甲氧基黄烷酮

5-Methoxyflavanone

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