2beta-乙酰弥罗松酚

2beta-Acetoxyferruginol

	产品编号	CFN92978
	CAS编号	1206461-56-4
	分子式 = 分子量	C₂₂H₃₂O₃ = 344.49
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The herbs of Salvia yunnanensis
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
2beta-乙酰弥罗松酚	CFN92978	1206461-56-4	1mg	QQ客服：2159513211
2beta-乙酰弥罗松酚	CFN92978	1206461-56-4	5mg	QQ客服：2159513211
2beta-乙酰弥罗松酚	CFN92978	1206461-56-4	10mg	QQ客服：2159513211
2beta-乙酰弥罗松酚	CFN92978	1206461-56-4	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

National Chung Hsing University (Taiwan)

Univerzita Karlova v Praze (Czech Republic)

Korea Intitute of Science and Technology (KIST) (Korea)

Seoul National University of Science and Technology (Korea)

Shanghai Institute of Organic Chemistry (China)

Shanghai Institute of Biochemistry and Cell Biology (China)

Donald Danforth Plant Science Center (USA)

Pennsylvania State University (USA)

Hamdard University (India)

MTT Agrifood Research Finland (Finland)

Universiti Malaysia Pahang (Malaysia)

Semmelweis Unicersity (Hungary)

University of Wisconsin-Madison (USA)

University of Vigo (Spain)

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Description:

2beta-Acetoxyferruginol showed activity against multidrug and methicillin-resistant Staphylococcus aureus (MRSA) strains and with Propionibacterium acnes, the major bacterial cause of acne, and the minimum inhibitory concentration value against P. acnes was 4 ug/ml.

Targets:

Antifection

In vitro:

Phytochemistry Letters, 2008, 1(1):49-53.

2β-Acetoxyferruginol—A new antibacterial abietane diterpene from the bark of Prumnopitys andina[Reference: WebLink]

As part of an on-going project to isolate antibacterial compounds from rare conifer species, a new abietane diterpene, 2beta-Acetoxyferruginol was isolated from the stem bark of Prumnopitys andina.
METHODS AND RESULTS:
Molecular modelling studies were conducted to explain some of the NOEs observed in the A-ring of this compound and to support assignment of relative stereochemistry. This new compound had antibacterial activity at 8 μg/ml against two effluxing strains of Staphylococcus aureus, but interestingly was inactive at 128 μg/ml against a wild-type strain and against a methicillin-resistant (MRSA) clinical isolate. We have previously demonstrated that ferruginol is active against these four S. aureus stains and therefore the results indicate that the presence of the acetoxy group has a detrimental effect on antibacterial activity against certain strains. 2beta-Acetoxyferruginol was also assayed against Propionibacterium acnes and was active at 4 μg/ml.Graphical abstractA new antibacterial abietane diterpene, 2beta-Acetoxyferruginol (1) was isolated from the stem bark of Prumnopitys andina and its structure was determined by spectral means.
CONCLUSIONS:
Activity was assessed against multidrug and methicillin-resistant Staphylococcus aureus (MRSA) strains and with Propionibacterium acnes, the major bacterial cause of acne, and the minimum inhibitory concentration value against P. acnes was 4 μg/ml.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
雷公藤酚E; Wilforol E	CFN91914	117456-86-7	C₂₁H₃₀O₃ = 330.46	5mg	QQ客服：2056216494
Triptonodiol; Triptonodiol	CFN96476	117456-87-8	C₂₁H₃₀O₄ = 346.46	5mg	QQ客服：2159513211
Benzaldehyde; Benzaldehyden	CFN92677	1072444-55-3	C₂₀H₂₈O₃ = 316.4	5mg	QQ客服：1457312923
Wulfenioidin G; Wulfenioidin G	CFN95816	N/A	C₂₀H₂₆O₃ = 314.4	5mg	QQ客服：1457312923
Isodon B; Isodon B	CFN95829	N/A	C₂₀H₂₆O₃ = 314.4	5mg	QQ客服：2056216494
5alpha,6-Dihydro-15-methoxysalviasperanol; 5alpha,6-Dihydro-15-methoxysalviasperanol	CFN95834	N/A	C₂₁H₃₀O₄ = 346.5	5mg	QQ客服：2159513211
弥罗松酚; 铁锈醇; Ferruginol	CFN92178	514-62-5	C₂₀H₃₀O = 286.5	5mg	QQ客服：2159513211
15-羟基弥罗松酚; 15-Hydroxyferruginol	CFN92329	76235-93-3	C₂₀H₃₀O₂ = 302.5	5mg	QQ客服：215959384
桧醇; Hinokiol	CFN98948	564-73-8	C₂₀H₃₀O₂ = 302.5	5mg	QQ客服：1413575084
(+)-扁柏酚; 3alpha-Hinokiol	CFN95814	107740-34-1	C₂₀H₃₀O₂ = 302.5	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9028 mL	14.5142 mL	29.0284 mL	58.0568 mL	72.571 mL
5 mM	0.5806 mL	2.9028 mL	5.8057 mL	11.6114 mL	14.5142 mL
10 mM	0.2903 mL	1.4514 mL	2.9028 mL	5.8057 mL	7.2571 mL
50 mM	0.0581 mL	0.2903 mL	0.5806 mL	1.1611 mL	1.4514 mL
100 mM	0.029 mL	0.1451 mL	0.2903 mL	0.5806 mL	0.7257 mL