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  • 2,3-脱氢水飞蓟宾A

    2,3-Dehydrosilybin A

    2,3-脱氢水飞蓟宾A
    产品编号 CFN70322
    CAS编号 25166-14-7
    分子式 = 分子量 C25H20O10 = 480.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Silybum marianum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    2,3-脱氢水飞蓟宾A CFN70322 25166-14-7 1mg QQ客服:3257982914
    2,3-脱氢水飞蓟宾A CFN70322 25166-14-7 5mg QQ客服:3257982914
    2,3-脱氢水飞蓟宾A CFN70322 25166-14-7 10mg QQ客服:3257982914
    2,3-脱氢水飞蓟宾A CFN70322 25166-14-7 20mg QQ客服:3257982914
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • ...
  • 生物活性
    Description: 2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound.
    In vitro:
    Free Radical Biology and Medicine, 2017, 103(Complete):256-267.
    2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound.[Reference: WebLink]
    Aging is an unavoidable process characterized by gradual failure of homeostasis that constitutes a critical risk factor for several age-related disorders. It has been unveiled that manipulation of various key pathways may decelerate the aging progression and the triggering of age-related diseases. As a consequence, the identification of compounds, preferably natural-occurring, administered through diet, with lifespan-extending, anti-aggregation and anti-oxidation properties that in parallel exhibit negligible side-effects is the main goal in the battle against aging.
    METHODS AND RESULTS:
    Here we analyze the role of 2,3-dehydrosilybin A/B (DHS A/B), a minor component of silymarin used in a plethora of dietary supplements. This flavonolignan is well-known for its anti-oxidative and neuroprotective properties, among others. We demonstrate that DHS A/B confers oxidative stress resistance not only in human primary cells but also in the context of a multi-cellular aging model, namely Caenorhabditis elegans (C. elegans) where it also promotes lifespan extension.
    CONCLUSIONS:
    We reveal that these DHS A/B outcomes are FGT-1 and DAF-16 dependent. We additionally demonstrate the anti-aggregation properties of DHS A/B in human cells of nervous origin but also in nematode models of Alzheimer's disease (AD), eventually leading to decelerated progression of AD phenotype. Our results identify DHS A/B as the active component of silymarin extract and propose DHS A/B as a candidate anti-aging and anti-aggregation compound.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0816 mL 10.408 mL 20.816 mL 41.632 mL 52.04 mL
    5 mM 0.4163 mL 2.0816 mL 4.1632 mL 8.3264 mL 10.408 mL
    10 mM 0.2082 mL 1.0408 mL 2.0816 mL 4.1632 mL 5.204 mL
    50 mM 0.0416 mL 0.2082 mL 0.4163 mL 0.8326 mL 1.0408 mL
    100 mM 0.0208 mL 0.1041 mL 0.2082 mL 0.4163 mL 0.5204 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2,3-脱氢水飞蓟宾; 2,3-Dehydrosilychristin CFN95370 57499-41-9 C25H20O10 = 480.4 5mg QQ客服:1413575084
    异水飞蓟宾; Isosilybin CFN90260 72581-71-6 C25H22O10 = 482.44 20mg QQ客服:1413575084
    异水飞蓟宾A; Isosilybin A CFN91070 142796-21-2 C25H22O10 = 482.4 5mg QQ客服:2159513211
    异水飞蓟宾B; Isosilybin B CFN91071 142796-22-3 C25H22O10 = 482.4 5mg QQ客服:2056216494
    水飞蓟宾; Silymarin CFN99542 22888-70-6 C25H22O10 = 482.46 20mg QQ客服:2056216494
    水飞蓟宾A; Silybin A CFN95149 22888-70-6 C25H22O10 = 482.4 20mg QQ客服:2056216494
    水飞蓟宾B; Silybin B CFN92916 142797-34-0 C25H22O10 = 482.44 20mg QQ客服:3257982914
    2,3-脱氢水飞蓟宾A; 2,3-Dehydrosilybin A CFN70322 25166-14-7 C25H20O10 = 480.4 5mg QQ客服:1413575084
    2,3-脱氢水飞蓟宾B; 2,3-Dehydrosilybin B CFN70271 142796-24-5 C25H20O10 = 480.4 5mg QQ客服:215959384
    水飞蓟宁; Silydianin CFN90242 29782-68-1 C25H22O10 = 482.44 20mg QQ客服:1457312923

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