α-鼠李糖

alpha-L-Rhamnose

	产品编号	CFN90450
	CAS编号	3615-41-6
	分子式 = 分子量	C₆H₁₂O₅ = 164.16
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Miscellaneous
	植物来源	The leaves of Rhus toxicodendron
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
α-鼠李糖	CFN90450	3615-41-6	10mg	QQ客服：2056216494
α-鼠李糖	CFN90450	3615-41-6	20mg	QQ客服：2056216494
α-鼠李糖	CFN90450	3615-41-6	50mg	QQ客服：2056216494
α-鼠李糖	CFN90450	3615-41-6	100mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of South Australia (Australia)

Amity University (India)

Auburn University (USA)

Kamphaengphet Rajabhat University (Thailand)

Weizmann Institute of Science (Israel)

Colorado State University (USA)

University of Virginia (USA)

University of East Anglia (United Kingdom)

Instytut Nawozów Sztucznych w Pu?awach (Poland)

University of Hull (United Kingdom)

Instituto Politécnico de Bragan?a (Portugal)

University of Illinois at Chicago (USA)

Stanford University (USA)

University of Dicle (Turkey)

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Description:

Addition of the Rhamnose-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose-dependent stimulation of the calcium-signaling pathway, inducing fast and transient increases in Ca2 influx and intracellular free Ca2 level.

Targets:

Calcium Channel

In vitro:

Biochim Biophys Acta. 2008 Dec;1780(12):1388-94.

The alpha-L-Rhamnose recognizing lectin site of human dermal fibroblasts functions as a signal transducer: modulation of Ca2+ fluxes and gene expression.[Pubmed: 18708125]

An alpha-L-Rhamnose specific lectin site was described on human skin keratinocytes and fibrobasts. The addition of Rhamnose-rich oligo- and polysaccharides (RROPs) to fibroblasts has been shown to stimulate cell proliferation and increase extracellular matrix biosynthesis, suggesting that this lectin site functions as a "true" receptor transmitting messages to the cell interior.
METHODS AND RESULTS:
It was confirmed here that addition of the Rhamnose-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose-dependent stimulation of the calcium-signaling pathway, inducing fast and transient increases in Ca2 influx and intracellular free Ca2 level. The Rhamnose-rich oligosaccharide RROP-3 as well as l-Rhamnose alone were also able to trigger similar intracellular free Ca2 concentration increases in NHDFs. Moreover, the recording of the RROP-1-induced modification of the gene-expression profile in fibroblasts showed that this polysaccharide triggered a down-regulation of the expression of several growth factors, adhesion molecules and extracellular matrix proteins involved in pro-tumoral activity and/or fibrotic processes.
CONCLUSIONS:
These results further support the hypothesis of a receptor function for the Rhamnose-recognizing lectin site in fibroblasts. Anti-fibrotic and anti-tumoral potential of RROP-1 remains to be further explored.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
6-Deoxy-3-O-methyl-beta-allopyranosyl(1-4)-beta-cymaronic acid delta-lactone; 6-Deoxy-3-O-methyl-beta-allopyranosyl(1-4)-beta-cymaronic acid delta-lactone	CFN99885	19131-13-6	C₁₄H₂₄O₈ = 320.3	5mg	QQ客服：2056216494
金线莲苷; Kinsenoside	CFN93288	151870-74-5	C₁₀H₁₆O₈ = 264.2	20mg	QQ客服：2159513211
维生素C；抗坏血酸; Ascorbic acid	CFN90048	50-81-7	C₆H₈O₈ = 176.12	20mg	QQ客服：215959384
抗坏血酸葡糖苷; Ascorbyl glucoside	CFN91548	129499-78-1	C₁₂H₁₈O₁₁ = 338.3	20mg	QQ客服：215959384
甲基beta-D-呋喃果糖苷; Methyl beta-D-fructofuranoside	CFN99418	13403-14-0	C₇H₁₄O₆ = 194.2	5mg	QQ客服：215959384
乙基BETA-D-呋喃果糖苷; Ethyl beta-D-fructofuranoside	CFN99849	1820-84-4	C₈H₁₆O₆ = 208.2	5mg	QQ客服：1457312923
D-阿拉伯糖; D-Arabinose	CFN93003	10323-20-3	C₅H₁₀O₅ = 150.1	20mg	QQ客服：2056216494
D-(+)-木糖; D-(+)-Xylose	CFN99911	58-86-6	C₅H₁₀O₅ = 150.13	20mg	QQ客服：1413575084
1,5-酐-D-山梨糖醇; 1,5-Anhydro-D-glucitol	CFN90078	154-58-5	C₆H₁₂O₅ = 164.16	5mg	QQ客服：1413575084
果糖; Fructose	CFN98121	57-48-7	C₆H₁₂O₆ = 180.16	20mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.0916 mL	30.4581 mL	60.9162 mL	121.8324 mL	152.2904 mL
5 mM	1.2183 mL	6.0916 mL	12.1832 mL	24.3665 mL	30.4581 mL
10 mM	0.6092 mL	3.0458 mL	6.0916 mL	12.1832 mL	15.229 mL
50 mM	0.1218 mL	0.6092 mL	1.2183 mL	2.4366 mL	3.0458 mL
100 mM	0.0609 mL	0.3046 mL	0.6092 mL	1.2183 mL	1.5229 mL