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  • 准葛尔乌头胺

    Songoramine

    准葛尔乌头胺
    产品编号 CFN96214
    CAS编号 23179-78-4
    分子式 = 分子量 C22H29NO3 = 355.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Aconitum brachypodum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    准葛尔乌头胺 CFN96214 23179-78-4 1mg QQ客服:1457312923
    准葛尔乌头胺 CFN96214 23179-78-4 5mg QQ客服:1457312923
    准葛尔乌头胺 CFN96214 23179-78-4 10mg QQ客服:1457312923
    准葛尔乌头胺 CFN96214 23179-78-4 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Parma (Italy)
  • Mahidol University (Thailand)
  • Sant Gadge Baba Amravati University (India)
  • Lodz University of Technology (Poland)
  • University of Fribourg (Switzerland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • In Vitro Cellular & Developmental Biology - Plant2022, 58:972-988.
  • Phytomedicine Plus2022, 2(1):100207.
  • Asian J Beauty Cosmetol2022, 20(2):183-191
  • Biochem Biophys Res Commun.2018, 505(1):194-200
  • Agriculture.2022, 12(3), 342.
  • Bio-protocol2018, 9(14):e3301
  • Toxins (Basel).2021, 13(9):593.
  • Appl Biochem Biotechnol.2022, s12010-022-04166-2.
  • Food Science and Human Wellness2022, 11(4):965-974
  • Pak J Pharm Sci.2018, 31:311-315
  • Molecules.2019, 24(1):E159
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • Nutrients.2020, 12(5):1242.
  • Oncotarget.2017, 9(3):4161-4172
  • Korean J. Food Preserv.2023, 30(4):663-668.
  • ScientificWorldJournal.2022, 2022:4806889.
  • QASCF2022, 14(4).
  • Journal of Food Quality2022, P:13, 6256310.
  • Phytomedicine.2021, 93:153789.
  • Foods. 2022, 11(23):3905.
  • Food Chem.2021, 377:131976.
  • Molecules.2021, 26(23):7390.
  • Plant Direct.2021, 5(12):e372.
  • ...
  • 生物活性
    Description: Songoramine(10 uM) demonstrates significant hERG K+ channel inhibition.
    Targets: Potassium Channel | hERG
    In vitro:
    Planta Med. 2011 Mar;77(4):368-73.
    Diterpene alkaloids from Aconitum anthora and assessment of the hERG-inhibiting ability of Aconitum alkaloids.[Pubmed: 20862641 ]
    A new norditerpene alkaloid, 10-hydroxy-8- O-methyltalatizamine (1), was isolated from the whole plant of ACONITUM ANTHORA L. besides the known isotalatizidine (2) and hetisinone (3).
    METHODS AND RESULTS:
    The structures were determined by means of HR-ESI-MS, 1D and 2D NMR spectroscopy, including 1H-1H COSY, NOESY, HSQC and HMBC experiments, resulting in complete 1H and 13C chemical shift assignments for 1- 3, and revision of some earlier 13C-NMR data. The effects of the isolated compounds, together with twenty-one other ACONITUM alkaloids with different skeletal types and substitution patterns, on hERG channels were studied by the whole-cell patch clamp technique, using the QPatch-16 automated patch clamp system.
    CONCLUSIONS:
    At 10 μM, aconitine, 14-benzoylaconine 8- O-palmitate, Songoramine, gigactonine and neolinine demonstrated significant hERG K+ channel inhibition; all other compounds exerted only low (6-21%) inhibitory activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8129 mL 14.0647 mL 28.1294 mL 56.2588 mL 70.3235 mL
    5 mM 0.5626 mL 2.8129 mL 5.6259 mL 11.2518 mL 14.0647 mL
    10 mM 0.2813 mL 1.4065 mL 2.8129 mL 5.6259 mL 7.0323 mL
    50 mM 0.0563 mL 0.2813 mL 0.5626 mL 1.1252 mL 1.4065 mL
    100 mM 0.0281 mL 0.1406 mL 0.2813 mL 0.5626 mL 0.7032 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    8-去乙酰基滇乌碱; Acoforestinine CFN99502 110011-77-3 C35H51NO10 = 645.79 20mg QQ客服:1413575084
    8-去乙酰滇乌碱; 8-Deacetylyunaconitine CFN89329 93460-55-0 C33H47NO10 = 617.73 5mg QQ客服:2056216494
    滇乌头碱; Yunaconitine CFN99503 70578-24-4 C35H49NO11 = 659.77 20mg QQ客服:2159513211
    3-乙酰滇乌碱; 3-Acetylyunaconitine CFN89362 80787-51-5 C37H51NO12 = 701.80 5mg QQ客服:1413575084
    草乌甲素; Bulleyaconitine A CFN99720 107668-79-1 C35H49NO10 = 643.8 20mg QQ客服:1413575084
    Carmichaenine D; Carmichaenine D CFN89455 2065228-62-6 C29H39NO7 = 513.62 5mg QQ客服:215959384
    Carmichaenine C; Carmichaenine C CFN89454 2065228-61-5 C30H41NO7 = 527.64 5mg QQ客服:2056216494
    黄草乌碱丙; Foresaconitine CFN93029 73870-35-6 C35H49NO9 = 627.77 5mg QQ客服:1457312923
    3-脱氧乌头碱; 3-Deoxyaconitine CFN90660 3175-95-9 C34H47NO10 = 629.74 20mg QQ客服:1413575084
    乌头碱; Aconitine CFN99915 302-27-2 C34H47NO11 = 645.75 20mg QQ客服:215959384

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