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    • 乌头碱

    Aconitine

    乌头碱
    		产品编号 CFN99915
    CAS编号 302-27-2
    分子式 = 分子量 C34H47NO11 = 645.75
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Aconitum kusnezoffii Reichb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    乌头碱 CFN99915 302-27-2 10mg QQ客服：1413575084
    乌头碱 CFN99915 302-27-2 20mg QQ客服：1413575084
    乌头碱 CFN99915 302-27-2 50mg QQ客服：1413575084
    乌头碱 CFN99915 302-27-2 100mg QQ客服：1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Tissue Cell.2022, 75:101728.
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  • ...
    • 生物活性
    Description: Aconitine, one of the major Aconitum alkaloids, is a highly toxic compound from the Aconitum species, it appears to exert a long-lasting cholinergic action in the causation of severe arrhythmias leading to death.
    Targets: P450 (e.g. CYP17)
    In vivo:
    Forensic Sci Int. 2005 Feb 10;148(1):21-9.
    Effects of long-term administrations of aconitine on electrocardiogram and tissue concentrations of aconitine and its metabolites in mice.[Pubmed: 15607586 ]
    Aconitum alkaloids are well known for their acute and high toxicity, for example, in the causation of severe arrhythmias leading to death. Aconitine, one of the major Aconitum alkaloids, is a highly toxic compound from the Aconitum species. However, there has been no studies reported on the influence of the chronic administration of aconitine. Thus, this study was conducted to investigate the influence of chronic administration of aconitine in experimental animal models.
    METHODS AND RESULTS:
    A dose of 1mg/kg per day was administered to the experimental animal models. We determined the concentration of aconitine and its metabolites (benzoylaconine and aconine) in organs and blood with gas chromatography/selected ion monitoring (GC/SIM). In addition, we concurrently recorded the electrocardiogram (ECG). Fifteen minutes after administration on day 0, the early aconitine administered group (acute group) revealed peak organ and blood concentration levels of aconitine with a gradual decrease, thereafter. The concentration of aconitine in organs and blood (from days 0 to 22; 90 min after the last administration of aconitine) gradually decreased according to repeated administration, whereas benzoylaconine and aconine increased. ECG revealed various types of arrhythmias. However, the frequency of arrhythmias remarkably decreased with time and repeated administration of aconitine.
    CONCLUSIONS:
    These results indicate two possibilities. First, the increase in the activity of aconitine metabolism. Secondly, the decrease of effectiveness to the heart due to long-term (chronic) administration of aconitine.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5486 mL 7.7429 mL 15.4859 mL 30.9717 mL 38.7147 mL
    5 mM 0.3097 mL 1.5486 mL 3.0972 mL 6.1943 mL 7.7429 mL
    10 mM 0.1549 mL 0.7743 mL 1.5486 mL 3.0972 mL 3.8715 mL
    50 mM 0.031 mL 0.1549 mL 0.3097 mL 0.6194 mL 0.7743 mL
    100 mM 0.0155 mL 0.0774 mL 0.1549 mL 0.3097 mL 0.3871 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    关附甲素; Guan-fu base A CFN91495 1394-48-5 C24H31NO6 = 429.5 5mg QQ客服：3257982914
    翠雀花定; Delgrandine CFN89550 145237-05-4 C41H43NO12 = 741.77 5mg QQ客服：215959384
    14-Dehydrodelcosine; 14-Dehydrodelcosine CFN89547 1361-18-8 C24H37NO7 = 451.55 5mg QQ客服：3257982914
    8-去乙酰基滇乌碱; Acoforestinine CFN99502 110011-77-3 C35H51NO10 = 645.79 20mg QQ客服：3257982914
    8-去乙酰滇乌碱; 8-Deacetylyunaconitine CFN89329 93460-55-0 C33H47NO10 = 617.73 5mg QQ客服：1457312923
    滇乌头碱; Yunaconitine CFN99503 70578-24-4 C35H49NO11 = 659.77 20mg QQ客服：3257982914
    3-乙酰滇乌碱; 3-Acetylyunaconitine CFN89362 80787-51-5 C37H51NO12 = 701.80 5mg QQ客服：1413575084
    草乌甲素; Bulleyaconitine A CFN99720 107668-79-1 C35H49NO10 = 643.8 20mg QQ客服：1413575084
    Carmichaenine D; Carmichaenine D CFN89455 2065228-62-6 C29H39NO7 = 513.62 5mg QQ客服：1457312923
    Carmichaenine C; Carmichaenine C CFN89454 2065228-61-5 C30H41NO7 = 527.64 5mg QQ客服：1457312923

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