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  • 山栀苷甲酯

    Shanzhiside methylester

    山栀苷甲酯
    产品编号 CFN97107
    CAS编号 64421-28-9
    分子式 = 分子量 C17H26O11 = 406.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Iridoids
    植物来源 The herbs of Lamiophlomis rotata (Benth.) Kudo.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    山栀苷甲酯 CFN97107 64421-28-9 10mg QQ客服:2159513211
    山栀苷甲酯 CFN97107 64421-28-9 20mg QQ客服:2159513211
    山栀苷甲酯 CFN97107 64421-28-9 50mg QQ客服:2159513211
    山栀苷甲酯 CFN97107 64421-28-9 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Rev. Chim.2020, 71(3),558-564
  • J Ethnopharmacol.2016, 192:370-381
  • Phytomedicine.2017, 24:77-86
  • Front Plant Sci.2023, 14:1207940.
  • Nutrients.2020, 12(3):595.
  • Arch Biochem Biophys.2020, 687:108363.
  • Food Sci Biotechnol.2021, 30(2):217-226.
  • Plant Foods Hum Nutr.2021, 76(4):472-477.
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  • Mol Med Rep.2023 Oct;28(4):193.
  • Food Chem.2021, 360:130063.
  • Molecules.2021, 26(2):E255.
  • Food Funct.2020, 11(2):1322-1333.
  • FEBS Lett.2015, 589(1):182-7
  • Antioxidants (Basel).2020, 9(4):326.
  • J Adv Res.2019, 17:85-94
  • BMC Complement Altern Med.2014, 14:242
  • Int J Cosmet Sci.2022, doi:10.1111/ics.12827.
  • Nutrients.2023, 15(6):1417.
  • Phytomedicine.2019, 67:153159
  • Front Microbiol.2022, 13:835463.
  • ...
  • 生物活性
    Description: Shanzhiside methylester reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p38 MAPK signaling.
    Targets: p38MAPK | GLP-1 receptor
    In vitro:
    Neuropharmacology . 2016 Feb;101:98-109.
    Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata, reduces neuropathic pain by stimulating spinal microglial β-endorphin expression[Pubmed: 26363192]
    Abstract Lamiophlomis rotata (L. rotata, Duyiwei) is an orally available Tibetan analgesic herb widely prescribed in China. Shanzhiside methylester (SM) is a principle effective iridoid glycoside of L. rotata and serves as a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist. This study aims to evaluate the signal mechanisms underlying SM anti-allodynia, determine the ability of SM to induce anti-allodynic tolerance, and illustrate the interactions between SM and morphine, or SM and β-endorphin, in anti-allodynia and anti-allodynic tolerance. Intrathecal SM exerted dose-dependent and long-lasting (>4 h) anti-allodynic effects in spinal nerve injury-induced neuropathic rats, with a maximal inhibition of 49% and a projected ED50 of 40.4 μg. SM and the peptidic GLP-1 receptor agonist exenatide treatments over 7 days did not induce self-tolerance to anti-allodynia or cross-tolerance to morphine or β-endorphin. In contrast, morphine and β-endorphin induced self-tolerance and cross-tolerance to SM and exenatide. In the spinal dorsal horn and primary microglia, SM significantly evoked β-endorphin expression, which was completely prevented by the microglial inhibitor minocycline and p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580. SM anti-allodynia was totally inhibited by the GLP-1 receptor antagonist exendin(9-39), minocycline, β-endorphin antiserum, μ-opioid receptor antagonist CTAP, and SB203580. SM and exenatide specifically activated spinal p38 MAPK phosphorylation. These results indicate that SM reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p38 MAPK signaling. Stimulation of the endogenous β-endorphin expression may be a novel and effective strategy for the discovery and development of analgesics for the long-term treatment of chronic pain. Keywords: Anti-allodynia; Glucagon-like peptide-1 (GLP-1) receptor; Microglia; Shanzhiside methylester (SM); p38 mitogen-activated protein kinase (MAPK); β-endorphin.
    In vivo:
    Neuropharmacology. 2016 Feb;101:98-109
    Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata, reduces neuropathic pain by stimulating spinal microglial β-endorphin expression.[Pubmed: 26363192 ]
    Lamiophlomis rotata (L. rotata, Duyiwei) is an orally available Tibetan analgesic herb widely prescribed in China. Shanzhiside methylester (SM) is a principle effective iridoid glycoside of L. rotata and serves as a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist. This study aims to evaluate the signal mechanisms underlying SM anti-allodynia, determine the ability of SM to induce anti-allodynic tolerance, and illustrate the interactions between SM and morphine, or SM and β-endorphin, in anti-allodynia and anti-allodynic tolerance.
    METHODS AND RESULTS:
    Intrathecal SM exerted dose-dependent and long-lasting (>4 h) anti-allodynic effects in spinal nerve injury-induced neuropathic rats, with a maximal inhibition of 49% and a projected ED50 of 40.4 μg. SM and the peptidic GLP-1 receptor agonist exenatide treatments over 7 days did not induce self-tolerance to anti-allodynia or cross-tolerance to morphine or β-endorphin. In contrast, morphine and β-endorphin induced self-tolerance and cross-tolerance to SM and exenatide. In the spinal dorsal horn and primary microglia, SM significantly evoked β-endorphin expression, which was completely prevented by the microglial inhibitor minocycline and p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580. SM anti-allodynia was totally inhibited by the GLP-1 receptor antagonist exendin(9-39), minocycline, β-endorphin antiserum, μ-opioid receptor antagonist CTAP, and SB203580. SM and exenatide specifically activated spinal p38 MAPK phosphorylation.
    CONCLUSIONS:
    These results indicate that SM reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p38 MAPK signaling. Stimulation of the endogenous β-endorphin expression may be a novel and effective strategy for the discovery and development of analgesics for the long-term treatment of chronic pain.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4606 mL 12.3031 mL 24.6063 mL 49.2126 mL 61.5157 mL
    5 mM 0.4921 mL 2.4606 mL 4.9213 mL 9.8425 mL 12.3031 mL
    10 mM 0.2461 mL 1.2303 mL 2.4606 mL 4.9213 mL 6.1516 mL
    50 mM 0.0492 mL 0.2461 mL 0.4921 mL 0.9843 mL 1.2303 mL
    100 mM 0.0246 mL 0.123 mL 0.2461 mL 0.4921 mL 0.6152 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    山栀苷甲酯; Shanzhiside methylester CFN97107 64421-28-9 C17H26O11 = 406.4 20mg QQ客服:215959384
    8-O-乙酰山栀苷甲酯; 8-O-Acetylshanzhiside methyl ester CFN98966 57420-46-9 C19H28O12 = 448.4 20mg QQ客服:215959384
    (E)-6-O-对香豆酰鸡屎藤次苷甲酯; (E)-6-O-(p-coumaroyl)scandoside methyl ester CFN95192 83946-90-1 C26H30O13 = 550.5 10mg QQ客服:1413575084
    6-O-反式对香豆酰山栀苷甲酯; 6-O-trans-p-Coumaroylshanzhiside methyl ester CFN99359 1246012-26-9 C26H32O13 = 552.5 5mg QQ客服:1413575084
    6Beta-野芝麻新甙; 6beta-Hydroxyipolamiide CFN97445 87797-84-0 C17H26O12 = 422.4 5mg QQ客服:3257982914
    环烯醚萜B; Phlorigidoside B CFN98356 288248-46-4 C19H28O13 = 464.4 5mg QQ客服:1457312923
    6-O-苯甲酰环烯醚萜B; 6-O-Benzoylphlorigidoside B CFN99357 1246012-24-7 C26H32O14 = 568.5 5mg QQ客服:2159513211
    6-O-trans-Cinnamoylphlorigidoside B; 6-O-trans-Cinnamoylphlorigidoside B CFN99358 1246012-25-8 C28H34O14 = 594.6 5mg QQ客服:1413575084

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