| Plant Cell, Tissue and Organ Culture, 1989,18(1):19-31. |
| Site of synthesis, metabolism and translocation of senecionine N-oxide in cultured roots of Senecio erucifolius[Reference: WebLink] |
METHODS AND RESULTS:
Root cultures of Senecio erucifolius (Asteraceae) efficiently took up and incorporated [14C]putrescine and [14C]arginine into the pyrrolizidine alkaloid (PA) senecionine N-oxide. Pulse-chase experiments covering a growth period of 10 to 19 days revealed the absence of any significant alkaloid turnover.
CONCLUSIONS:
The only metabolic activity was a slow but progressive transformation of senecionine N-oxide into its dehydrogenation product, Seneciphylline N-oxide. |
| Phytochemistry,1997,45(3):489-497. |
| Selective sequestration and metabolism of plant derived pyrrolizidine alkaloids by chrysomelid leaf beetles[Reference: WebLink] |
METHODS AND RESULTS:
A novel PA not found in the food plants was detected in the defensive secretions of Oreina elongata; it was identified as 13,19-expoxisenecionine N-oxide (oreine), the epoxidation product of Seneciphylline N-oxide. Besides this transformation, leaf beetles are able to catalyse further transformations such as the O-dealkylation of heliotrine N-oxide to rinderine N-oxide and the O-deacetylation of acetylSeneciphylline N-oxide to Seneciphylline N-oxide.
CONCLUSIONS:
The plant-beetle interactions are discussed in the functional context of PAs as powerful plant defensive chemicals. |
| Journal of Comparative Physiology A,2003,189(11):833-841. |
| Experience influences gustatory responsiveness to pyrrolizidine alkaloids in the polyphagous caterpillar, Estigmene acrea[Reference: WebLink] |
METHODS AND RESULTS:
Electrophysiological recordings from taste sensilla of the caterpillar Estigmene acrea with the pyrrolizidine alkaloid, seneciphylline N-oxide, demonstrated that prior feeding on plants with pyrrolizidine alkaloids caused an increase in responsiveness of the PA-sensitive cells in two sensilla, relative to feeding on plants without such chemicals. |
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