| In vitro: |
| J Nat Prod. 2009 Nov;72(11):2019-23. | | Inhibition of the dimerization and active site of HIV-1 protease by secondary metabolites from the Vietnamese mushroom Ganoderma colossum.[Pubmed: 19813754 ] |
METHODS AND RESULTS:
A new farnesyl hydroquinone, ganomycin I (1), was isolated along with ganomycin B (2) from the chloroform extract of the fruiting bodies of the Vietnamese mushroom Ganoderma colossum. These compounds inhibited HIV-1 protease with IC50 values of 7.5 and 1.0 microg/mL, respectively.
CONCLUSIONS:
Kinetic studies using Zhang-Poorman and Lineweaver plots revealed that compound 2 competitively inhibited the active site of the enzyme, whereas the tetracyclic triterpene Schisanlactone A, previously isolated from the same fungus, was a dimerization inhibitor, with an IC50 value of 5.0 microg/mL. The previous findings were also confirmed by the virtual docking of both compounds with HIV-1 protease crystal structure. | | Fitoterapia. 2013 Dec;91:125-7. | | Cattienoids A-C, three novel steroids from the mushroom Tomophagus cattienensis.[Pubmed: 24001711 ] |
METHODS AND RESULTS:
Three novel steroids (1-3), named cattienoids A-C together with Schisanlactone A (4), were isolated from fruiting bodies of Tomophagus cattienensis (Ganodermataceae)-a new mushroom recently collected from Cattien National Park, in Viet Nam. They possess an unusual seven membered lactone ring, derived from lanostane-type triterpenoids. Their structures were determined by spectroscopic methods. In addition, compounds 2 and 4 showed cytotoxicity against KB (a human epidermal carcinoma) cells with their IC50 values of 91.2 and 63.3 μM, respectively.
CONCLUSIONS:
These compounds have neither antimicrobial activity nor inhibition of the tyrosinase. |
|
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