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  • 王百合苷I

    • 王百合苷I

    Regaloside I

    王百合苷I
    		产品编号 CFN95525
    CAS编号 126239-78-9
    分子式 = 分子量 C20H26O11 = 442.4
    产品纯度 >=98%
    物理属性 Solid
    化合物类型 Phenols
    植物来源 The rhizomes of Lilium brownii var. viridulum Baker
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    王百合苷I CFN95525 126239-78-9 1mg QQ客服：1413575084
    王百合苷I CFN95525 126239-78-9 5mg QQ客服：1413575084
    王百合苷I CFN95525 126239-78-9 10mg QQ客服：1413575084
    王百合苷I CFN95525 126239-78-9 20mg QQ客服：1413575084
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  • ...
    • 生物活性
    Description: Regaloside I, which has the structure of phenylpropanolglycerol glycoside, acts as an active compound that inhibits the upregulation of CAPZA1 and inhibits UVA-induced changes in HDF shape, which in turn inhibits collagen reduction.
    In vitro:
    Exp Dermatol . 2016 Aug;25 Suppl 3:45-51.
    Morphological change of skin fibroblasts induced by UV Irradiation is involved in photoaging[Pubmed: 27539902]
    Human dermal fibroblasts (HDFs) are typically flattened or extensible shaped and play a critical role in the metabolism of extracellular matrix components. As the properties of fibroblasts in the dermis are considered to be influenced by their morphology, we investigated the morphological changes induced in fibroblasts by ultraviolet (UV) irradiation as well as the relationship between these changes and collagen metabolism. In this study, we showed that UVA exposure induced morphological changes and reduced collagen contents in HDFs. These morphological changes were accompanied a reduction in actin filaments and upregulation of the actin filament polymerization inhibitor, capping protein muscle Z-line ɑ1 (CAPZA1). External actin filament growth inhibitors also affected the shape of HDFs and reduced collagen levels. These results suggest that UVA exposure may inhibit the polymerization of actin filaments and induce morphological changes in skin fibroblasts. These morphological changes in fibroblasts may accelerate reductions in collagen synthesis. This mechanism may be one of the processes responsible for collagen reductions observed in photoaged skin. When natural materials that suppress these morphological changes in HDFs were evaluated, we found that an extract of Lilium 'Casa Blanca' (LCB) suppressed UVA-induced alterations in the shape of HDFs, which are typically followed by inhibition of collagen reduction. An analysis of the active compounds in LCB extract led to the identification of regaloside I, which had a structure of phenylpropanoid glycerol glucoside, as the active compound inhibiting the upregulation of CAPZA1. Therefore, inhibition of UVA-induced morphological changes in HDFs is considered to be promising way for the suppression of collagen reduction in photoaging.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2604 mL 11.302 mL 22.604 mL 45.208 mL 56.5099 mL
    5 mM 0.4521 mL 2.2604 mL 4.5208 mL 9.0416 mL 11.302 mL
    10 mM 0.226 mL 1.1302 mL 2.2604 mL 4.5208 mL 5.651 mL
    50 mM 0.0452 mL 0.226 mL 0.4521 mL 0.9042 mL 1.1302 mL
    100 mM 0.0226 mL 0.113 mL 0.226 mL 0.4521 mL 0.5651 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    王百合苷A; Regaloside A CFN91852 114420-66-5 C18H24O10 = 400.4 10mg QQ客服：2159513211
    王百合苷B; Regaloside B CFN91844 114420-67-6 C20H26O11 = 442.4 20mg QQ客服：2056216494
    王百合苷C; Regaloside C CFN91843 117591-85-2 C18H24O11 = 416.4 10mg QQ客服：2159513211
    王百合苷D; Regaloside D CFN91842 120601-66-3 C18H24O10 = 400.4 5mg QQ客服：2056216494
    王百合苷F; Regaloside F CFN91798 120601-65-2 C19H26O11 = 430.40 5mg QQ客服：215959384
    王百合苷H; Regaloside H CFN91799 126239-77-8 C18H24O10 = 400.38 5mg QQ客服：2056216494
    王百合苷I; Regaloside I CFN95525 126239-78-9 C20H26O11 = 442.4 5mg QQ客服：1457312923
    Oblongaroside B; Oblongaroside B CFN95543 1000889-11-1 C20H26O10 = 426.4 10mg QQ客服：2056216494

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