Niazirin

	产品编号	CFN96998
	CAS编号	122001-32-5
	分子式 = 分子量	C₁₄H₁₇NO₅ = 279.29
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The leaves of Moringa oleifera.
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产品名称	产品编号	CAS编号	包装	QQ客服
Niazirin	CFN96998	122001-32-5	1mg	QQ客服：215959384
Niazirin	CFN96998	122001-32-5	5mg	QQ客服：215959384
Niazirin	CFN96998	122001-32-5	10mg	QQ客服：215959384
Niazirin	CFN96998	122001-32-5	20mg	QQ客服：215959384

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Description:

The Moringa oleifera extract(including niaziridin and Niazirin) can successfully attenuate the development of pulmonary hypertension via direct vasodilatation and a potential increase in antioxidant activity.

In vitro:

Mutat Res. 1999 Apr 6;440(2):181-8.

An antitumor promoter from Moringa oleifera Lam.[Pubmed: 10209341]

In the course of studies on the isolation of bioactive compounds from Philippine plants, the seeds of Moringa oleifera Lam. were examined and from the ethanol extract were isolated the new O-ethyl-4-(alpha-L-rhamnosyloxy)benzyl carbamate (1) together with seven known compounds, 4(alpha-L-rhamnosyloxy)-benzyl isothiocyanate (2), niazimicin (3), Niazirin (4), beta-sitosterol (5), glycerol-1-(9-octadecanoate) (6), 3-O-(6'-O-oleoyl-beta-D-glucopyranosyl)-beta-sitosterol (7), and beta-sitosterol-3-O-beta-D-glucopyranoside (8).
METHODS AND RESULTS:
Four of the isolates (2, 3, 7, and 8), which were obtained in relatively good yields, were tested for their potential antitumor promoting activity using an in vitro assay which tested their inhibitory effects on Epstein-Barr virus-early antigen (EBV-EA) activation in Raji cells induced by the tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA). All the tested compounds showed inhibitory activity against EBV-EA activation, with compounds 2, 3 and 8 having shown very significant activities. Based on the in vitro results, niazimicin (3) was further subjected to in vivo test and found to have potent antitumor promoting activity in the two-stage carcinogenesis in mouse skin using 7,12-dimethylbenz(a)anthracene (DMBA) as initiator and TPA as tumor promoter.
CONCLUSIONS:
From these results, niazimicin (3) is proposed to be a potent chemo-preventive agent in chemical carcinogenesis.

In vivo:

Chin J Physiol. 2012 Apr 30;55(2):101-7.

Effects of 2-azafluorenones on phosphatidyl-inositol specific phospholipase C activation in c6 glioma cells.[Pubmed: 22559734 ]

The purpose of this study was to determine the effects of an extract from Moringa oleifera (MO) on the development of monocrotaline (MCT)-induced pulmonary hypertension (PH) in Wistar rats. An ethanol extraction was performed on dried MO leaves, and HPLC analysis identified niaziridin and Niazirin in the extract.
METHODS AND RESULTS:
PH was induced with a single subcutaneous injection of MCT (60 mg/kg) which resulted in increases in pulmonary arterial blood pressure (Ppa) and in thickening of the pulmonary arterial medial layer in the rats. Three weeks after induction, acute administration of the MO extract to the rats decreased Ppa in a dose-dependent manner that reached statistical significance at a dose of 4.5 mg of freeze-dried extract per kg body weight. The reduction in Ppa suggested that the extract directly relaxed the pulmonary arteries. To assay the effects of chronic administration of the MO extract on PH, control, MCT and MCT+MO groups were designated. Rats in the control group received a saline injection; the MCT and MCT+MO groups received MCT to induce PH. During the third week after MCT treatment, the MCT+MO group received daily i.p. injections of the MO extract (4.5 mg of freeze-dried extract/kg of body weight). Compared to the control group, the MCT group had higher Ppa and thicker medial layers in the pulmonary arteries. Chronic treatments with the MO extract reversed the MCT-induced changes. Additionally, the MCT group had a significant elevation in superoxide dismutase activity when normalized by the MO extract treatments.
CONCLUSIONS:
In conclusion, the MO extract successfully attenuated the development of PH via direct vasodilatation and a potential increase in antioxidant activity.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
4-羟基苯甲酰胺; 4-Hydroxybenzamide	CFN97063	619-57-8	C₇H₇NO₂ = 137.1	20mg	QQ客服：1413575084
苯甲酰胺; Benzamide	CFN98925	55-21-0	C₇H₇NO = 121.1	5mg	QQ客服：215959384
钝叶扁柏氨基甲酸酯 A; Obtucarbamate A	CFN96025	6935-99-5	C₁₁H₁₄N₂O₄ = 238.2	20mg	QQ客服：2159513211
钝叶扁柏氨基甲酸酯 B; Obtucarbamate B	CFN96026	20913-18-2	C₁₁H₁₄N₂O₄ = 238.2	10mg	QQ客服：2159513211
2-氨基-1-苯乙醇; 2-Amino-1-phenylethanol	CFN00052	111025-00-4	C₁₅H₁₅NO₂ = 241.29	5mg	QQ客服：1457312923
N-Benzoyl-2-hydroxy-2-phenylethylamine; N-Benzoyl-2-hydroxy-2-phenylethylamine	CFN00053	111059-46-2	C₁₅H₁₅NO₂ = 241.29	5mg	QQ客服：3257982914
Muricatide; Muricatide	CFN00054	111025-01-5	C₁₇H₁₇NO₃ = 283.33	5mg	QQ客服：3257982914
苄胺; Benzylamine	CFN00064	100-46-9	C₇H₉N = 107.15	5mg	QQ客服：215959384
N-甲基苄胺; N-Methylbenzylamine	CFN00065	103-67-3	C₈H₁₁N = 121.18	5mg	QQ客服：2056216494
2-羟基苄胺; 2-Hydroxybenzylamine	CFN00079	932-30-9	C₇H₉NO = 123.15	20mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5805 mL	17.9025 mL	35.8051 mL	71.6102 mL	89.5127 mL
5 mM	0.7161 mL	3.5805 mL	7.161 mL	14.322 mL	17.9025 mL
10 mM	0.3581 mL	1.7903 mL	3.5805 mL	7.161 mL	8.9513 mL
50 mM	0.0716 mL	0.3581 mL	0.7161 mL	1.4322 mL	1.7903 mL
100 mM	0.0358 mL	0.179 mL	0.3581 mL	0.7161 mL	0.8951 mL

Niazirin

Niazirin

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