Info: Read More
  • 中药标准品生产商,产品定制服务
  • 苄胺

    Benzylamine

    苄胺
    产品编号 CFN00064
    CAS编号 100-46-9
    分子式 = 分子量 C7H9N = 107.15
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Alkaloids
    植物来源 The herbs of Moringa oleifera
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    苄胺 CFN00064 100-46-9 1mg QQ客服:2159513211
    苄胺 CFN00064 100-46-9 5mg QQ客服:2159513211
    苄胺 CFN00064 100-46-9 10mg QQ客服:2159513211
    苄胺 CFN00064 100-46-9 20mg QQ客服:2159513211
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Padjajaran (Indonesia)
  • University of Cincinnati (USA)
  • University of Pretoria (South Africa)
  • University of the Basque Country (Spain)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Gyeongsang National University (Korea)
  • University of Malaya (Malaysia)
  • Institute of Chinese Materia Medica (China)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • University of Minnesota (USA)
  • Technical University of Denmark (Denmark)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Sapienza University of Rome (Italy)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Immunol.2018, 9:2091
  • Molecules.2016, 21(6)
  • J Med Food.2022, 25(3):272-280.
  • Anticancer Res.2014, 34(7):3505-9
  • In Vivo.2022, 36(3):1136-1143.
  • J of Essential Oil Research2019, 1677272
  • Journal of functional foods2018, 171-182
  • Food Sci Biotechnol.2023, 32(9):1215-1223.
  • Cell Death Dis.2019, 10(12):882
  • Antioxidants (Basel).2020, 9(7):581.
  • Arch Biochem Biophys.2020, 687:108363.
  • Int J Mol Sci.2021, 22(12):6466.
  • Appl. Sci.2020, 10(23), 8729
  • Analytical Methods2018, 10(27)
  • Nutr Cancer.2022, 1-13.
  • Int J Mol Sci.2021, 22(14):7324.
  • Inflammation.2015, 38(4):1502-16
  • Oncotarget.2017, 8(64):108006-108019
  • Dicle Tip Dergisi2020, 47(2),423-430.
  • J Pharm Biomed Anal.2019, 164:119-127
  • Molecules.2019, 24(11):E2044
  • J Sci Food Agric.2017, 97(5):1656-1662
  • Oncotarget.2017, 9(3):4161-4172
  • ...
  • 生物活性
    Description: Benzylamine has antihyperglycemic effect, observed during glucose tolerance test in control.
    Targets: MAO
    In vitro:
    Bioorg Med Chem Lett. 2013 Apr 1;23(7):2177-80.
    Deconstruction of sulfonamide inhibitors of the urotensin receptor (UT) and design and synthesis of benzylamine and benzylsulfone antagonists.[Pubmed: 23453841]
    Potent small molecule antagonists of the urotensin receptor are described.
    METHODS AND RESULTS:
    These inhibitors were derived via systematically deconstructing a literature inhibitor to understand the basic pharmacophore and key molecular features required to inhibit the protein receptor.
    CONCLUSIONS:
    The series of benzylamine and benzylsulfone antagonists herein reported display a combination of nanomolar molecular and cellular potency as well as acceptable in vitro permeability and metabolic stability.
    In vivo:
    J Physiol Biochem. 2012 Dec;68(4):651-62.
    Benzylamine antihyperglycemic effect is abolished by AOC3 gene invalidation in mice but not rescued by semicarbazide-sensitive amine oxidase expression under the control of aP2 promoter.[Pubmed: 22547093]
    Semicarbazide-sensitive amine oxidase (SSAO) is a transmembrane enzyme that metabolizes primary amines from endogenous or dietary origin. SSAO is highly expressed in adipose, smooth muscle and endothelial cells. In each of these cell types, SSAO is implicated in different biological functions, such as glucose transport activation, extracellular matrix maturation and leucocyte extravasation, respectively. However, the physiological functions of SSAO and their involvement in pathogenesis remain uncompletely characterized.
    METHODS AND RESULTS:
    To better understand the role of adipose tissue SSAO, we investigated whether it was necessary and/or sufficient to produce the antihyperglycemic effect of the SSAO-substrate benzylamine, already reported in mice. Therefore, we crossed SSAO-deficient mice invalidated for AOC3 gene and transgenic mice expected to express human SSAO in an adipocyte-specific manner, under the control of aP2 promoter. The aP2-human AOC3 construct (aP2-hAOC3) was equally expressed in the adipose tissue of mice expressing or not the native murine form and almost absent in other tissues. However, the corresponding SSAO activity found in adipose tissue represented only 20 % that of control mice. As a consequence, the benzylamine antihyperglycemic effect observed during glucose tolerance test in control was abolished in AOC3-KO mice but not rescued in mice expressing aP2-hAOC3. The capacity of benzylamine or methylamine to activate glucose uptake in adipocytes exhibited parallel variations in the corresponding genotypes.
    CONCLUSIONS:
    Although the aP2-hAOC3 construct did not allow a total rescue of SSAO activity in adipose tissue, it could be assessed from our observations that adipocyte SSAO plays a pivotal role in the increased glucose tolerance promoted by pharmacological doses of benzylamine.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 9.3327 mL 46.6636 mL 93.3271 mL 186.6542 mL 233.3178 mL
    5 mM 1.8665 mL 9.3327 mL 18.6654 mL 37.3308 mL 46.6636 mL
    10 mM 0.9333 mL 4.6664 mL 9.3327 mL 18.6654 mL 23.3318 mL
    50 mM 0.1867 mL 0.9333 mL 1.8665 mL 3.7331 mL 4.6664 mL
    100 mM 0.0933 mL 0.4666 mL 0.9333 mL 1.8665 mL 2.3332 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Niazimicin; Niazimicin CFN89363 147821-49-6 C16H23NO6S = 357.42 5mg QQ客服:215959384
    Niazirin; Niazirin CFN96998 122001-32-5 C14H17NO5 = 279.29 5mg QQ客服:1413575084
    Moringin; Moringin CFN89445 73255-40-0 C14H17NO5S = 311.35 5mg QQ客服:1457312923
    4-羟基苯甲酰胺; 4-Hydroxybenzamide CFN97063 619-57-8 C7H7NO2 = 137.1 20mg QQ客服:3257982914
    苯甲酰胺; Benzamide CFN98925 55-21-0 C7H7NO = 121.1 5mg QQ客服:2159513211
    钝叶扁柏氨基甲酸酯 A; Obtucarbamate A CFN96025 6935-99-5 C11H14N2O4 = 238.2 20mg QQ客服:3257982914
    钝叶扁柏氨基甲酸酯 B; Obtucarbamate B CFN96026 20913-18-2 C11H14N2O4 = 238.2 10mg QQ客服:3257982914
    2-氨基-1-苯乙醇; 2-Amino-1-phenylethanol CFN00052 111025-00-4 C15H15NO2 = 241.29 5mg QQ客服:215959384
    N-Benzoyl-2-hydroxy-2-phenylethylamine; N-Benzoyl-2-hydroxy-2-phenylethylamine CFN00053 111059-46-2 C15H15NO2 = 241.29 5mg QQ客服:2056216494
    Muricatide; Muricatide CFN00054 111025-01-5 C17H17NO3 = 283.33 5mg QQ客服:1457312923

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产