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  • 一枝蒿庚素； 准葛尔乌头碱

    • 一枝蒿庚素； 准葛尔乌头碱

    Napellonine

    一枝蒿庚素； 准葛尔乌头碱
    		产品编号 CFN90393
    CAS编号 509-24-0
    分子式 = 分子量 C22H31NO3 = 357.49
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Alkaloids
    植物来源 The roots of Aconitumso ngoricum Popov
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    一枝蒿庚素； 准葛尔乌头碱 CFN90393 509-24-0 10mg QQ客服：1413575084
    一枝蒿庚素； 准葛尔乌头碱 CFN90393 509-24-0 20mg QQ客服：1413575084
    一枝蒿庚素； 准葛尔乌头碱 CFN90393 509-24-0 50mg QQ客服：1413575084
    一枝蒿庚素； 准葛尔乌头碱 CFN90393 509-24-0 100mg QQ客服：1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Appl Biol Chem2023, 66:455−461
  • Pharmacol Rep.2022, 74(1):175-188.
  • Plant Direct.2021, 5(4):e00318.
  • Food Science and Human Wellness2022, 11(4):965-974
  • Chinese J of Tissue Engineering Res.2022, 26(17): 2636-2641.
  • LWT2021, 138:110397.
  • Phytomedicine.2016, 23(4):331-9
  • Front Pharmacol.2017, 8:673
  • HortTechnology2016, 26(6):816-819
  • Sci Rep.2017, 7(1):3249
  • J of Essential Oil Research2019, 1677272
  • Biomolecules.2021, 11(10):1537.
  • Plant Physiol Biochem.2019, 144:355-364
  • Talanta.2022, 249:123645.
  • JMSACL2023, 09.002
  • Korean J. Medicinal Crop Sci2021, 10:345-352.
  • Toxicol Appl Pharmacol.2022, 434:115815.
  • Phytomedicine.2019, 55:229-237
  • Anat Rec2018, 24264
  • Asian J Beauty Cosmetol2021, 19(1): 57-64.
  • Int J Biol Macromol.2020, 161:1230-1239.
  • Cancers (Basel).2021, 13(9):2223.
  • bioRxiv2021, 462065.
  • ...
    • 生物活性
    Description: Napellonine shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.
    Targets: FGFR4
    In vivo:
    Sci Rep. 2017 Jun 15;7(1):3569.
    A novel cell membrane affinity sample pretreatment technique for recognition and preconcentration of active components from traditional Chinese medicine.[Pubmed: 28620157 ]
    We describe a novel biomembrane affinity sample pretreatment technique to quickly screen and preconcentrate active components from traditional Chinese medicine (TCM), which adopts cell membrane coated silica particles (CMCSPs) as affinity ligands which benefit the biomembrane's ability to maximize simulation of drug-receptor interactions in vivo.
    METHODS AND RESULTS:
    In this study, the prepared CMCSPs formed by irreversible adsorption of fibroblast growth factor receptor 4 (FGFR4) cell membrane on the surface of silica were characterized using different spectroscopic and imaging instruments. Drug binding experiments showed the excellent adsorption rate and adsorption capacity of FGFR4/CMCSPs compared with non-coated silica particles. The FGFR4/CMCSPs were used as solid-phase extraction sorbents to pretreat the TCM Aconitum szechenyianum Gay. The resultant FGFR4/CMCSPs exhibited good performance. In addition, high selectivity and recognition ability of the FGFR4/CMCSPs were determined by selectivity experiments. Four alkaloid were screened and identified, one of these alkaloid, Napellonine, showed favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.
    CONCLUSIONS:
    The proposed cell membrane affinity sample pretreatment method is a reliable, effective and time-saving method for fast screening and enriching active compounds and can be extended to pretreat other TCMs as leading compounds resources.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7973 mL 13.9864 mL 27.9728 mL 55.9456 mL 69.932 mL
    5 mM 0.5595 mL 2.7973 mL 5.5946 mL 11.1891 mL 13.9864 mL
    10 mM 0.2797 mL 1.3986 mL 2.7973 mL 5.5946 mL 6.9932 mL
    50 mM 0.0559 mL 0.2797 mL 0.5595 mL 1.1189 mL 1.3986 mL
    100 mM 0.028 mL 0.1399 mL 0.2797 mL 0.5595 mL 0.6993 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    8-去乙酰基滇乌碱; Acoforestinine CFN99502 110011-77-3 C35H51NO10 = 645.79 20mg QQ客服：2159513211
    8-去乙酰滇乌碱; 8-Deacetylyunaconitine CFN89329 93460-55-0 C33H47NO10 = 617.73 5mg QQ客服：2056216494
    滇乌头碱; Yunaconitine CFN99503 70578-24-4 C35H49NO11 = 659.77 20mg QQ客服：2056216494
    3-乙酰滇乌碱; 3-Acetylyunaconitine CFN89362 80787-51-5 C37H51NO12 = 701.80 5mg QQ客服：3257982914
    草乌甲素; Bulleyaconitine A CFN99720 107668-79-1 C35H49NO10 = 643.8 20mg QQ客服：1457312923
    Carmichaenine D; Carmichaenine D CFN89455 2065228-62-6 C29H39NO7 = 513.62 5mg QQ客服：3257982914
    Carmichaenine C; Carmichaenine C CFN89454 2065228-61-5 C30H41NO7 = 527.64 5mg QQ客服：215959384
    黄草乌碱丙; Foresaconitine CFN93029 73870-35-6 C35H49NO9 = 627.77 5mg QQ客服：1413575084
    3-脱氧乌头碱; 3-Deoxyaconitine CFN90660 3175-95-9 C34H47NO10 = 629.74 20mg QQ客服：1457312923
    乌头碱; Aconitine CFN99915 302-27-2 C34H47NO11 = 645.75 20mg QQ客服：1413575084

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