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    忍冬苷

    Lonicerin

    忍冬苷
    产品编号 CFN95055
    CAS编号 25694-72-8
    分子式 = 分子量 C27H30O15 = 594.5
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Lonicera hypoglauca
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    忍冬苷 CFN95055 25694-72-8 1mg QQ客服:1413575084
    忍冬苷 CFN95055 25694-72-8 5mg QQ客服:1413575084
    忍冬苷 CFN95055 25694-72-8 10mg QQ客服:1413575084
    忍冬苷 CFN95055 25694-72-8 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Indian Institute of Science (India)
  • University of Vienna (Austria)
  • Stanford University (USA)
  • Harvard University (USA)
  • Universidad Industrial de Santander (Colombia)
  • Max-Planck-Insitut (Germany)
  • Complutense University of Madrid (Spain)
  • Utah State University (USA)
  • Universidad Miguel Hernández (Spain)
  • University of Toulouse (France)
  • Medical University of Gdansk (Poland)
  • The University of Newcastle (Australia)
  • University of Queensland (Australia)
  • Max Rubner-Institut (MRI) (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Ethnopharmacol.2017, 198:205-213
  • J Nat Med.2017, 71(4):745-756
  • Food Res Int.2017, 96:40-45
  • J of Engineering Science&Technology2018, 13(9):2820-2828
  • Integr Cancer Ther.2018, 17(3):832-843
  • Chemistry of Natural Compounds2018, 204–206
  • Molecules.2018, 23(10):E2638
  • Biol Pharm Bull.2018, 41(11):1685-1693
  • Pathogens.2018, 7(3):E62
  • Planta Med.2018, 84(6-07):465-474
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • Food Res Int.2019, 123:125-134
  • Int J Mol Sci.2019, 20(11):E2734
  • Food Chem.2019, 275:746-753
  • Phytomedicine.2019, 58:152893
  • J Clin Med.2019, 8(10):E1664
  • Metabolites.2020, 11(1):E11.
  • Int J Biol Macromol.2020, 169:342-351
  • UDC.2020, 19(4).
  • J Biotechnol.2020, 318:10-19.
  • Processes2020, 8(12),1540.
  • Functional Ecology2020, doi: 10.1111.
  • Ulm University Medical Center2020, doi: 10.18725.
  • ...
  • 生物活性
    Description: Lonicerin has antioxidant, anti-arthritic and antifungal activities, it can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.
    Targets: Antifection
    In vitro:
    J Sep Sci. 2008 Oct;31(20):3519-26.
    Rapid and simple method for screening of natural antioxidants from Chinese herb Flos Lonicerae Japonicae by DPPH-HPLC-DAD-TOF/MS.[Pubmed: 18830958 ]
    A rapid and simple method has been developed for the screening and identification of natural antioxidants of Flos Lonicerae Japonicae (FLJ), derived from the flower buds of Lonicera japonica.
    METHODS AND RESULTS:
    The hypothesis is that upon reaction with 1,1-diphenyl-2-picrylhydrazyl (DPPH), the peak areas (PAs) of compounds with potential antioxidant effects in the HPLC chromatograms will be significantly reduced or disappeared, and the identity confirmation could be achieved by HPLC-DAD-TOF/MS hyphenated technique. Using the proposed approach, about 14 compounds in the FLJ extract were found to possess a potential antioxidant activity. They were identified as chlorogenic acid (1), 1-O-caffeoylquinic acid (1-O-CQA, 2), caffeic acid (4), 4-O-CQA (5), rutin (7), isoquercitrin (8), luteolin-7-O-glucoside (9), Lonicerin (10), 4,5-O-dicaffeoylquinic acid (4,5-O-diCQA, 11), 3,5-O-diCQA (12), 1,3-O-diCQA (13), 3,4-O-diCQA (14), 1,4-O-diCQA (16), and luteolin (17). In addition, the free radical scavenging capacities of the available identified compounds were also investigated by HPLC assay.
    CONCLUSIONS:
    The results indicated that the compounds with PAs significantly decreasing were natural antioxidants, whereas those with PAs not changing presented no activities, which accordingly indicated that this newly proposed method could be widely applied for rapid screening and identification of natural antioxidants from complex matrices including Chinese herbal medicines.
    In vivo:
    Arch Pharm Res. 2011 May;34(5):853-9.
    Antiarthritic effect of lonicerin on Candida albicans arthritis in mice.[Pubmed: 21656372 ]
    Fungal arthritis is a potentially serious disease resulting in rapid destruction of the joint. Among the various Candida species, Candida albicans is the most commonly associated with fungal arthritis.
    METHODS AND RESULTS:
    In the present study, we examined the effect of Lonicerin, a flavonoid isolated from Lonicerae Flos, on an arthritis caused by C. albicans cell wall (CACW) in mice. To examine the effect, an emulsified mixture of CACW and complete Freund's adjuvant (CACW/CFA) was injected into BALB/c mice via hind footpad route on days -3, -2, and -1. On Day 0, mice with the swollen footpad received Lonicerin at 1 or 2 mg/dose/time intraperitoneally 3 times every other day. The footpad-swelling was measured for 20 days. Results showed that the Lonicerin treatment reduced the edema at all dose levels, and, furthermore, there was app. 54% edema reduction in animals given the 2 mg-dose at the peak (day 10) of septic arthritis (p < 0.05). Since the peak, the edema was reduced in similar rates. This antiarthritic activity appeared to be mediated by Lonicerin's ability to suppress T cell proliferation, nitric oxide production from macrophages, and shift of cellular immunity from Th1- toward Th2-type responses, all of which are beneficial to treat arthritis. In addition, the flavonoid had anticandidal activity (p < 0.01).
    CONCLUSIONS:
    These data suggest that Lonicerin alone, which has both anti-arthritic and antifungal activities, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6821 mL 8.4104 mL 16.8209 mL 33.6417 mL 42.0521 mL
    5 mM 0.3364 mL 1.6821 mL 3.3642 mL 6.7283 mL 8.4104 mL
    10 mM 0.1682 mL 0.841 mL 1.6821 mL 3.3642 mL 4.2052 mL
    50 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.6728 mL 0.841 mL
    100 mM 0.0168 mL 0.0841 mL 0.1682 mL 0.3364 mL 0.4205 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    假荆芥属苷; Nepetin-7-glucoside CFN90438 569-90-4 C22H22O12 = 478.40 10mg QQ客服:2159513211
    万寿菊苷; Patulitrin CFN95153 19833-25-1 C22H22O13 = 494.4 5mg QQ客服:1413575084
    柯伊利素-7-O-葡萄糖苷; Chrysoeriol-7-O-glucoside CFN93021 19993-32-9 C22H22O11 = 462.4 5mg QQ客服:2159513211
    香叶木素7-O-beta-D-葡萄糖苷; Diosmetin-7-O-beta-D-glucopyranoside CFN98502 20126-59-4 C22H22O11 = 462.41 20mg QQ客服:3257982914
    地奥司明; Diosmin CFN98145 520-27-4 C28H32O15 = 608.54 20mg QQ客服:2932563308
    Lethedoside A; Lethedoside A CFN98100 221289-20-9 C24H26O11 = 490.5 5mg QQ客服:2056216494
    Lethedioside A; Lethedioside A CFN98201 221289-31-2 C29H34O15 = 622.6 5mg QQ客服:1413575084
    5-羟基-7,8,2',5'-四甲氧基黄酮 5-O-葡萄糖苷; 5-Hydroxy-7,8,2',5'-tetramethoxyflavone 5-O-glucoside CFN97595 942626-75-7 C25H28O12 = 520.49 5mg QQ客服:1413575084
    木犀草苷; 木犀草素-7-O-葡萄糖苷; Luteolin-7-O-glucoside CFN98565 5373-11-5 C21H20O11 = 448.38 20mg QQ客服:2056216494
    木犀草素-7-O-葡萄糖醛酸苷; Luteolin-7-O-glucuronide CFN98512 29741-10-4 C21H18O12 = 462.36 20mg QQ客服:2932563308

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