| In vitro: |
| Biol Pharm Bull. 1998 Apr;21(4):360-5. | | Metabolism of kalopanaxsaponin B and H by human intestinal bacteria and antidiabetic activity of their metabolites.[Pubmed: 9586573] | To investigate the relationship between the intestinal bacterial metabolism of kalopanaxsaponin B and Kalopanaxsaponin H from Kalopanax pictus (Araliaceae), and their antidiabetic effect, kalopanaxsaponin B and Kalopanaxsaponin H were metabolized by human intestinal microflora and the antidiabetic activity of their metabolites was measured.
METHODS AND RESULTS:
Kalopanaxsaponin H was metabolized to kalopanaxsaponin A and I, hederagenin 3-O-alpha-L-arabinopyranoside and hederagenin. The main metabolites of Kalopanaxsaponin H were kalopanaxsaponin I and hederagenin. Among kalopanaxsaponin B, H and their metabolites, kalopanaxsaponin A showed the most potent antidiabetic activity, followed by hederagenin. However, the main components, kalopanaxsaponin B and Kalopanaxsaponin H, in K. pictus were inactive. | | Biol Pharm Bull. 2002 Jan;25(1):68-71. | | Metabolism of kalopanaxsaponin K by human intestinal bacteria and antirheumatoid arthritis activity of their metabolites.[Pubmed: 11824560] |
METHODS AND RESULTS:
When kalopanaxsaponin K (KPK) from Kalopanax pictus was incubated for 24 h at 37 degrees C with human intestinal microflora, KPK was mainly metabolized to kalopanaxsaponin I (KPI) via Kalopanaxsaponin H (KPH) rather than via kalopanaxsaponin J (KPJ), and then transformed to kalopanaxsaponin A (KPA) and hederagenin. Bacteroides sp., and Bifidobacterium sp. and Fusobacterium sp. transformed KPK to KPI and KPA and hederagenin via Kalopanaxsaponin H or KPJ. However, Lactobacillus sp. and Streptococcus sp. transformed KPK to KPI, KPA, and hederagenin only via KPJ.
CONCLUSIONS:
The metabolite KPA of KPK showed potent antirheumatoid arthritis activity. |
|
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)
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