欧天芥菜碱

Heleurine

	产品编号	CFN00239
	CAS编号	488-00-6
	分子式 = 分子量	C₁₆H₂₇NO₄ = 297.39
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Alkaloids
	植物来源	The herbs of Heliotropium indicum L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
欧天芥菜碱	CFN00239	488-00-6	1mg	QQ客服：215959384
欧天芥菜碱	CFN00239	488-00-6	5mg	QQ客服：215959384
欧天芥菜碱	CFN00239	488-00-6	10mg	QQ客服：215959384
欧天芥菜碱	CFN00239	488-00-6	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Almansora University (Egypt)

University of Minnesota (USA)

University of Liège (Belgium)

National Cancer Institute (USA)

University of Sao Paulo (Brazil)

Macau University of Science and Technology (China)

National Research Council of Canada (Canada)

Charles Sturt University (Denmark)

Chiang Mai University (Thailand)

Ain Shams University (Egypt)

University of Queensland (Australia)

University of Hertfordshire (United Kingdom)

The Australian National University (Australia)

Auburn University (USA)

More...

Description:

Heleurine, platyphylline, supinine and cynaustraline are more potent in antagonizing responses to acetylcholine and carbachol than responses to histamine.

Targets:

AChR

In vitro:

Br J Pharmacol. 1971 Apr;41(4):683-90.

Pyrrolizidine alkaloids: actions on muscarinic receptors in the guinea-pig ileum.[Pubmed: 5579465 ]

METHODS AND RESULTS:
1. Eleven pyrrolizidine alkaloids have been tested on the isolated guinea-pig ileum preparation.2. Platyphylline, supinine, Heleurine and cynaustraline were more potent in antagonizing responses to acetylcholine and carbachol than responses to histamine. Their anticholinergic activity appeared to involve a competitive mechanism.3. Lasiocarpine, monocrotaline, spectabiline, sarracine, 7-angelylheliotridine, heliotrine and senecionine had similar antagonistic potencies against responses to both acetylcholine and histamine.
CONCLUSIONS:
4. The alkaloids had no appreciable activity as antagonists of acetylcholine in the isolated toad rectus abdominis preparation.5. These results are discussed with respect to interactions of the alkaloids at receptor sites involved in anticholinergic activity at the muscarinic receptor.

In vivo:

Veterinary and human toxicology 09/2003; 45(4):198-201.

Toxicity of dietary Heliotropium circinatum to rats.[Reference: WebLink]

METHODS AND RESULTS:
Pyrrolizidine alkaloid intoxication was produced in adult, male rats by feeding different levels (0, 1, 3, 5 or 10%) of Heliotropium circinatum for 20 w. Combined GC-MS revealed 0.15% total alkaloid content in the plant material of which 12% and 88% were basic and N-oxide forms, respectively. The specific alkaloids identified were europine (67.33%), heliotrine (16.34%), lasiocarpine (8.12%), heleurine (4.18%), echinatine (1.56%), 7-angeylheliotrine (1.19%), and an unknown alkaloid (1.28%). Neither mortality nor significant clinical changes occurred in test groups. Mild to moderate, dose-related hepatic megalocytosis was the most prominent histopathological finding. In addition to chronic hepatotoxicity, notable medial thickening occurred in the pulmonary arterioles and arteries of the high-dosed groups.
CONCLUSIONS:
This study indicated that H. circinatum plant has limited toxic potential in rats with mild to moderate histological changes and no mortality at the dosing levels, total doses, or time of exposure employed.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
倒提壶灵，倒提壶碱; Amabiline	CFN00236	17958-43-9	C₁₅H₂₅NO₄ = 283.37	5mg	QQ客服：1413575084
琉璃草亭; Cynaustine	CFN00237	17958-39-3	C₁₅H₂₅NO₄ = 283.37	5mg	QQ客服：3257982914
仰卧天芥菜碱; Supinine	CFN00238	551-58-6	C₁₅H₂₅NO₄ = 283.37	5mg	QQ客服：2056216494
欧天芥菜碱; Heleurine	CFN00239	488-00-6	C₁₆H₂₇NO₄ = 297.39	5mg	QQ客服：1413575084
Absouline; Absouline	CFN00240	112513-33-4	C₁₇H₂₂N₂O₂ = 286.37	5mg	QQ客服：3257982914
Isoabsouline; Isoabsouline	CFN00241	112513-34-5	C₁₇H₂₂N₂O₂ = 286.37	5mg	QQ客服：2056216494
Anchustrigosine; Anchustrigosine	CFN00242	N/A	C₂₄H₄₁NO₈ = 471.59	5mg	QQ客服：3257982914
Assamicadine; Assamicadine	CFN00244	126260-96-6	C₁₆H₂₃NO₅ = 309.36	5mg	QQ客服：2159513211
Bohemamine; Bohemamine	CFN00245	72926-12-6	C₁₄H₁₈N₂O₃ = 262.30	5mg	QQ客服：2056216494
Callimorphine; Callimorphine	CFN00246	74991-73-4	C₁₅H₂₃NO₅ = 297.35	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3626 mL	16.8129 mL	33.6259 mL	67.2518 mL	84.0647 mL
5 mM	0.6725 mL	3.3626 mL	6.7252 mL	13.4504 mL	16.8129 mL
10 mM	0.3363 mL	1.6813 mL	3.3626 mL	6.7252 mL	8.4065 mL
50 mM	0.0673 mL	0.3363 mL	0.6725 mL	1.345 mL	1.6813 mL
100 mM	0.0336 mL	0.1681 mL	0.3363 mL	0.6725 mL	0.8406 mL