野菊花内酯
Handelin
|
产品编号 |
CFN90906 |
CAS编号 |
62687-22-3 |
分子式 = 分子量 |
C32H40O8 = 552.7 |
产品纯度 |
>=98% |
物理属性 |
Powder |
化合物类型 |
Triterpenoids |
植物来源 |
The herbs of Dendranthema indicum |
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
野菊花内酯 |
CFN90906 |
62687-22-3 |
1mg |
QQ客服:2159513211 |
野菊花内酯 |
CFN90906 |
62687-22-3 |
5mg |
QQ客服:2159513211 |
野菊花内酯 |
CFN90906 |
62687-22-3 |
10mg |
QQ客服:2159513211 |
野菊花内酯 |
CFN90906 |
62687-22-3 |
20mg |
QQ客服:2159513211 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
Melbourne University (Australia)
Universidad de Antioquia (Colombia)
Technical University of Denmark (Denmark)
Universiti Kebangsaan Malaysia (Malaysia)
National Cancer Institute (USA)
Universiti Putra Malaysia(UPM) (Malaysia)
University of Perugia (Italy)
Texas A&M University (USA)
National Research Council of Canada (Canada)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
University of Stirling (United Kingdom)
Centralised Purchases Unit (CPU), B.I.T.S (India)
Mahidol University (Thailand)
Imperial College London (United Kingdom)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
Description: |
Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions. |
Targets: |
NO | PGE | TNF-α | IL Receptor | NF-kB | MAPK | ERK | JNK | IkB | IKK |
In vitro: |
Planta Med 2012; 78 - PD86. | Request full-text Anti-inflammatory activity of handelin through the modulation of NF-κB signaling and pro-inflammatory cytokine productions[Reference: WebLink] | Handelin, a guaianolide dimer, is a constituent of the flower of Chrysanthemum boreale Makino (Compositae). C. boreale have been used as traditional medicines for the treatment of vertigo and fever in Asian countries.
METHODS AND RESULTS:
The present study was designed to investigate the anti-inflammatory potential of Handelin in vitro and in vivo. Handelin inhibited LPS-stimulated production of NO and PGE2 in cultured mouse macrophage RAW 264.7 cells. The suppression of NO and PGE2 production by Handelin was correlated with the down-regulation of mRNA and protein expressions of iNOS and COX-2. Further study revealed that Handelin suppressed the induction of pro-inflammatory cytokines including TNF-α and IL-1β as well as microRNA-155 in LPS-induced RAW264.7 cells. Activation of the transcriptional activity of NF-κB by LPS was also alleviated by Handelin, which was well coincided with its inhibitory effect on IκB degradation. In addition, the activation of MAPKs such as ERK and JNK signaling was suppressed by Handelin. In in vivo animal model, oral administration of Handelin inhibited carrageenan-induced paw edema and TPA-induced ear edema, respectively. The analysis of cytokine production in serum showed that Handelin dose-dependently inhibited the production of IL-1β in a carrageenan-induced paw edema.
CONCLUSIONS:
These findings suggest that Handelin might be an active ingredient of C. boreale with the anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.
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|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
1.8093 mL |
9.0465 mL |
18.093 mL |
36.186 mL |
45.2325 mL |
5 mM |
0.3619 mL |
1.8093 mL |
3.6186 mL |
7.2372 mL |
9.0465 mL |
10 mM |
0.1809 mL |
0.9046 mL |
1.8093 mL |
3.6186 mL |
4.5232 mL |
50 mM |
0.0362 mL |
0.1809 mL |
0.3619 mL |
0.7237 mL |
0.9046 mL |
100 mM |
0.0181 mL |
0.0905 mL |
0.1809 mL |
0.3619 mL |
0.4523 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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