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    • 匙羹藤新苷元

    Gymnemagenin

    匙羹藤新苷元
    		产品编号 CFN90961
    CAS编号 22467-07-8
    分子式 = 分子量 C30H50O6 = 506.71
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The leaves of Gymnema sylvestre.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    匙羹藤新苷元 CFN90961 22467-07-8 1mg QQ客服：3257982914
    匙羹藤新苷元 CFN90961 22467-07-8 5mg QQ客服：3257982914
    匙羹藤新苷元 CFN90961 22467-07-8 10mg QQ客服：3257982914
    匙羹藤新苷元 CFN90961 22467-07-8 20mg QQ客服：3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Massachusetts General Hospital (USA)
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  • University of Toronto (Canada)
  • Medical University of Gdansk (Poland)
  • Periyar University (India)
  • Institute of Chinese Materia Medica (China)
  • University of Helsinki (Finland)
  • Sri Ramachandra University (India)
  • University of Eastern Finland (Finland)
  • Agricultural Research Organization (ARO) (Israel)
  • Macau University of Science and Technology (China)
  • Shanghai University of TCM (China)
  • University of Medicine and Pharmacy (Romania)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2015, 16(1):1232-51
  • Environ Toxicol.2020, doi: 10.1002
  • Molecules.2021, 26(6):1738.
  • J Pharm Biomed Anal2016, 118:183-194
  • Appl. Sci.2020, 10(23), 8729
  • Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36
  • Biol Pharm Bull.2017, 40(6):797-806
  • Separations2021, 8(6),80.
  • PLoS One.2015, 10(5):e0127060
  • J of l. Chroma.&Related Tech2020, 43(11-12):414-423.
  • Med Sci Monit.2019, 25:9499-9508
  • Antioxidants (Basel).2021, 10(1):112.
  • ACS Omega.2021, 6(36):23460-23474.
  • Korean J of Medicinal Crop Science2018, 220-226
  • J Nat Prod.2015, 78(6):1339-4
  • iScience.2023, 26(9):107602.
  • Applied Biological Chemistry2022, 65(12)
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • Appl. Sci. 2021, 11(8),3437.
  • Sci Rep.2023, 13(1):21690.
  • J Ethnopharmacol.2019, 244:112074
  • Nutrients.2021, 13(12):4364.
  • Cell Physiol Biochem.2019, 52(6):1255-1266
  • ...
    • 生物活性
    Description: Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity, it can be considered further for development into a potent anti-diabetic drug.
    Targets: Liver X Receptor
    In vitro:
    J Theor Biol. 2016 Feb 21;391:95-101.
    In-silico analysis of gymnemagenin from Gymnema sylvestre (Retz.) R.Br. with targets related to diabetes.[Pubmed: 26711684 ]
    Diabetes is a metabolic disorder characterized by higher than normal glucose in the blood. Most oral hypoglycemic drugs available in market produce adverse side effects which have resulted in continued search for new therapeutic agents with little or no side effects. Herbal drugs are considered relatively safer alternatives and Gymnema sylvestre is one of the most well established natural remedy for diabetes and is traded worldwide under several brands.
    METHODS AND RESULTS:
    In the present study an attempt has been made to use in silico techniques to understand and predict the drug likeliness of gymnemagenin, one of the key constituents of G. sylvestre against 15 proteins having key role in carbohydrate metabolism. Gymnemagenin was found to dock well with crystallographic structures of 7 of the 15 selected targets and was found even better than the two known clinically used antidiabetic compounds, repaglinide and sitagliptin taken in the study for comparison.
    CONCLUSIONS:
    Gymnemagenin therefore can be considered further for development into a potent anti-diabetic drug.
    In vivo:
    J Agric Food Chem. 2012 Mar 14;60(10):2517-24.
    Hypoglycemic activity of Gymnema sylvestre extracts on oxidative stress and antioxidant status in diabetic rats.[Pubmed: 22360666 ]
    Diabetes mellitus, which is associated with oxidative damage, has a significant impact on health, quality of life, and life expectancy. An ethanol extract of Gymnema sylvestre leaf was examined in vitro and in vivo to investigate the role of antioxidants in diabetic rats.
    METHODS AND RESULTS:
    The extract exhibited strong antioxidant activity in the assays, including TBA (56%), SOD-like (92%), and ABTS (54%). Blood glucose levels in the diabetic rats fed G. sylvestre extract decreased to normal levels. The presence of the antihyperglycemic compounds gymnemagenin and gymnemic acids in G. sylvestre extract was detected by LC/MS analysis. Lipid peroxidation levels were decreased by 31.7% in serum, 9.9% in liver, and 9.1% in kidney in the diabetic rats fed the extract. Feeding G. sylvestre extract to the diabetic rats decreased the activity of glutathione peroxidase in cytosolic liver and glutamate pyruvate transaminase in serum to normal levels.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9735 mL 9.8676 mL 19.7352 mL 39.4703 mL 49.3379 mL
    5 mM 0.3947 mL 1.9735 mL 3.947 mL 7.8941 mL 9.8676 mL
    10 mM 0.1974 mL 0.9868 mL 1.9735 mL 3.947 mL 4.9338 mL
    50 mM 0.0395 mL 0.1974 mL 0.3947 mL 0.7894 mL 0.9868 mL
    100 mM 0.0197 mL 0.0987 mL 0.1974 mL 0.3947 mL 0.4934 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    alpha-乳香酸; alpha-Boswellic acid CFN98704 471-66-9 C30H48O3 = 456.7 20mg QQ客服：2159513211
    乙酰基-alpha-乳香酸; 3-O-Acetyl-alpha-boswellic acid CFN90529 89913-60-0 C32H50O4 = 498.74 10mg QQ客服：2056216494
    3beta-羟基齐墩果-12-烯-27-酸; Beta-Peltoboykinolic acid CFN96343 24778-48-1 C30H48O3 = 456.7 5mg QQ客服：215959384
    3-软脂酸赤二醇酯; Erythrodiol 3-palmitate CFN98004 19833-13-7 C46H80O3 = 681.1 5mg QQ客服：2159513211
    23-羟基龙吉苷元; 23-Hydroxylongispinogenin CFN90948 42483-24-9 C30H50O4 = 474.72 5mg QQ客服：3257982914
    匙羹藤苷元; Gymnestrogenin CFN90966 19942-02-0 C30H50O5 = 490.72 5mg QQ客服：1413575084
    匙羹藤新苷元; Gymnemagenin CFN90961 22467-07-8 C30H50O6 = 506.71 10mg QQ客服：2056216494
    21-O-巴豆酰基匙羹藤新苷元; 21-O-Tigloylgymnemagenin CFN90978 1581276-63-2 C35H56O7 = 588.81 5mg QQ客服：215959384
    原七叶皂苷元; Protoescigenin CFN70307 20853-07-0 C30H50O6 = 506.7 5mg QQ客服：1413575084
    齐墩果-12-烯-3,24-二醇; Olean-12-ene-3,24-diol CFN99305 119318-15-9 C30H50O2 = 442.7 5mg QQ客服：1457312923

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