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  • 灵芝酸D

    Ganoderic acid D

    灵芝酸D
    产品编号 CFN90292
    CAS编号 108340-60-9
    分子式 = 分子量 C30H42O7 = 514.66
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝酸D CFN90292 108340-60-9 1mg QQ客服:3257982914
    灵芝酸D CFN90292 108340-60-9 5mg QQ客服:3257982914
    灵芝酸D CFN90292 108340-60-9 10mg QQ客服:3257982914
    灵芝酸D CFN90292 108340-60-9 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Fribourg (Switzerland)
  • Aveiro University (Portugal)
  • Universidad de La Salle (Mexico)
  • Sri Ramachandra University (India)
  • University of Madras (India)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Florida A&M University (USA)
  • University of Illinois at Chicago (USA)
  • University of Liège (Belgium)
  • National Chung Hsing University (Taiwan)
  • Biotech R&D Institute (USA)
  • Univerzita Karlova v Praze (Czech Republic)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J. of Agricultural Science2015, 1916-9760
  • Phytomedicine.2015, 22(4):498-503
  • Proc Natl Acad Sci USA.2016, 113(30):E4407-1
  • Mediators Inflamm.2016, 2016:7216912
  • Braz J Med Biol Res. 2016, 49(7)
  • J Agric Food Chem.2016, 64(35):6783-90
  • Biochem Systematics and Ecology2017, 11-18
  • Molecules.2017, 22(12)
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • Korean Journal of Pharmacognosy2017, 48(4):320-328
  • J Nat Med.2017, 71(4):745-756
  • Nutrients.2018, 10(10)
  • Analytical Methods2018, 10(27)
  • Food Quality and Safety2018, 2:213-219
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • South African J of Plant&Soil2018, 29-32
  • Cell Biochem Funct.2018, 36(6):303-311
  • Sci Adv.2018, 4(10)
  • Front Pharmacol.2019, 10:1226
  • Mol Microbiol.2019, 112(1):317-332
  • Chinese Medicine2019, 14(1)
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • ...
  • 生物活性
    Description: Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(50) value of 17.3 +/- 0.3 microM.
    In vitro:
    Mol Cell Proteomics. 2008 May;7(5):949-61.
    Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network.[Pubmed: 18166740]
    Triterpenes isolated from Ganoderma lucidum could inhibit the growth of numerous cancer cell lines and were thought to be the basis of the anticancer effects of G. lucidum. Ganoderic acid D (GAD) is one of the major components in Ganoderma triterpenes. GAD treatment for 48 h inhibited the proliferation of HeLa human cervical carcinoma cells with an IC(50) value of 17.3 +/- 0.3 microM. Flow cytometric analysis and DNA fragmentation analysis indicated that Ganoderic acid D induced G(2)/M cell cycle arrest and apoptosis.
    METHODS AND RESULTS:
    To identify the cellular targets of Ganoderic acid D, two-dimensional gel electrophoresis was performed, and proteins altered in expressional level after Ganoderic acid D exposure of cells were identified by MALDI-TOF MS/MS. The regulation of proteins was also confirmed by Western blotting. The cytotoxic effect of Ganoderic acid D was associated with regulated expression of 21 proteins. Furthermore these possible Ganoderic acid D target-related proteins were evaluated by an in silico drug target searching program, INVDOCK. The INVDOCK analysis results suggested that Ganoderic acid D could bind six isoforms of 14-3-3 protein family, annexin A5, and aminopeptidase B. The direct binding affinity of Ganoderic acid D toward 14-3-3 zeta was confirmed in vitro using surface plasmon resonance biosensor analysis. In addition, the intensive study of functional association among these 21 proteins revealed that 14 of them were closely related in the protein-protein interaction network. They had been found to either interact with each other directly or associate with each other via only one intermediate protein from previous protein-protein interaction experimental results. When the network was expanded to a further interaction outward, all 21 proteins could be included into one network.
    CONCLUSIONS:
    In this way, the possible network associated with Ganoderic acid D target-related proteins was constructed, and the possible contribution of these proteins to the cytotoxicity of Ganoderic acid D is discussed in this report.
    In vivo:
    Drug Metab Dispos. 2012 Dec;40(12):2307-14.
    Identification of metabolites of ganoderic acid D by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.[Pubmed: 22942320]
    Ganoderic acid D (GD) is the major active triterpenoid in Ganoderma lucidum, a medicinal fungus used daily. However, the metabolic fate of Ganoderic acid D remains unknown. To know whether Ganoderic acid D is extensively metabolized, we first investigated the metabolism of Ganoderic acid D in vitro and in vivo.
    METHODS AND RESULTS:
    The metabolic profiles of the bile samples obtained from rats in vivo were almost the same as those obtained in vitro. Using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry, a total of 25 metabolites were identified from the bile sample. Few metabolites were found in the urine samples. These results indicated that biliary rather than renal clearance was the major route of excretion. The major metabolites were identified by comparison with the standard reference compounds. Metabolites at low concentrations were identified by interpreting the mass spectra. Both phase I and phase II metabolites were observed. The metabolic transformation included reduction, monohydroxylation, dihydroxylation, trihydroxylation, oxidation, desaturation, sulfation, and glucuronidation. The main metabolic soft spots in the chemical structure of Ganoderic acid D were the 3-carbonyl group, angular methyl groups, the 7-hydroxy group, and the 26-carboxylic acid moiety.
    CONCLUSIONS:
    Overall, this study gives us an insight into the metabolism of Ganoderic acid D, an active oxygenated tetracyclic triterpenoid.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.943 mL 9.7152 mL 19.4303 mL 38.8606 mL 48.5758 mL
    5 mM 0.3886 mL 1.943 mL 3.8861 mL 7.7721 mL 9.7152 mL
    10 mM 0.1943 mL 0.9715 mL 1.943 mL 3.8861 mL 4.8576 mL
    50 mM 0.0389 mL 0.1943 mL 0.3886 mL 0.7772 mL 0.9715 mL
    100 mM 0.0194 mL 0.0972 mL 0.1943 mL 0.3886 mL 0.4858 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝酸D; Ganoderic acid D CFN90292 108340-60-9 C30H42O7 = 514.66 10mg QQ客服:3257982914
    12-羟基灵芝酸D; 12-Hydroxyganoderic acid D CFN91921 942950-96-1 C30H42O8 = 530.65 10mg QQ客服:2932563308
    12β-灵芝酸M; Ganoderic acid M CFN90747 100761-17-9 C30H42O8 = 530.7 5mg QQ客服:2932563308
    灵芝酸Z; Ganoderic acid Z CFN90295 294674-09-2 C30H42O7 = 514.66 5mg QQ客服:2932563308
    灵芝酸AM1; Ganoderic acid AM1 CFN90296 149507-55-1 C30H42O7 = 514.66 5mg QQ客服:1413575084
    Ethyl ganoderate J; Ethyl ganoderate J CFN92576 1189555-95-0 C32H46O7 = 542.7 5mg QQ客服:3257982914
    灵芝酸B; Ganoderic acid B CFN92052 81907-61-1 C30H44O7 = 516.7 10mg QQ客服:215959384
    灵芝烯酸B; Ganoderenic acid B CFN92991 100665-41-6 C30H42O7 = 514.65 5mg QQ客服:1413575084
    灵芝酸C2; Ganoderic acid C2 CFN92054 103773-62-2 C30H46O7 = 518.7 10mg QQ客服:2159513211
    灵芝酸A; Ganoderic acid A CFN92051 81907-62-2 C30H44O7 = 516.7 20mg QQ客服:1148253675

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