Info: Read More
  • 中药标准品生产商,产品定制服务
  • Science | Nature | Cell | View More

    镰叶芹醇

    Falcarinol

    镰叶芹醇
    产品编号 CFN96027
    CAS编号 21852-80-2
    分子式 = 分子量 C17H24O = 244.4
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Lipids
    植物来源 The roots of Saposhnikovia divaricata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    镰叶芹醇 CFN96027 21852-80-2 1mg QQ客服:2056216494
    镰叶芹醇 CFN96027 21852-80-2 5mg QQ客服:2056216494
    镰叶芹醇 CFN96027 21852-80-2 10mg QQ客服:2056216494
    镰叶芹醇 CFN96027 21852-80-2 20mg QQ客服:2056216494
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Pretoria (South Africa)
  • Universidade de Franca (Brazil)
  • University of Bordeaux (France)
  • University of Eastern Finland (Finland)
  • National Cancer Institute (USA)
  • University of British Columbia (Canada)
  • University of Otago (New Zealand)
  • Semmelweis Unicersity (Hungary)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Deutsches Krebsforschungszentrum (Germany)
  • Kamphaengphet Rajabhat University (Thailand)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Regional Crop Research Institute (Korea)
  • Seoul National University of Science and Technology (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • New Zealand J. Forestry Sci.2014, 44:17
  • Fitoterapia.2015, 100:179-86
  • Exp Parasitol.2015, 153:160-4
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • Braz J Med Biol Res. 2016, 49(7)
  • J Pharm Anal.2016, 6(6):363-373
  • Polytechnic University of Catalonia2017, 105826
  • Molecules.2017, 22(11)
  • Molecules.2017, 22(2)
  • Nutrients.2018, 11(1):E17
  • Pharmacol Rep.2018, 70(6):1195-1201
  • Virulence.2018, 9(1):588-603
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1113:1-13
  • Front Neurosci.2019, 13:1091
  • Neuropharmacology2019, 151437
  • Int J Mol Sci.2019, 20(11):E2734
  • Molecules.2019, 24(19):E3417
  • Chinese Pharmacological Bulletin2019, 35(8):1120-1125
  • Oxid Med Cell Longev2019, 9056845:13
  • Antioxidants (Basel).2020, 9(2):E99
  • Asian Pac J Cancer Prev. 2020, 21(4):935-941.
  • J Food Biochem.2020, 44(6):e13198.
  • Institut Pasteur Korea2020, doi: 10.21203.
  • ...
  • 生物活性
    Description: Falcarinol has effects on CaCo-2 cells appear to be biphasic, inducing pro-proliferative and apoptotic characteristics at low and high concentrations of Falcarinol, respectively. Falcarinol-associated dermatitis is due to antagonism of the CB(1) receptor in keratinocytes, leading to increased chemokine expression and aggravation of histamine action.
    Targets: IL Receptor | TNF-α | Caspase
    In vitro:
    Biochem Pharmacol. 2010 Jun 15;79(12):1815-26.
    Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin.[Pubmed: 20206138]
    The skin irritant polyyne Falcarinol (panaxynol, carotatoxin) is found in carrots, parsley, celery, and in the medicinal plant Panax ginseng.
    METHODS AND RESULTS:
    In our ongoing search for new cannabinoid (CB) receptor ligands we have isolated Falcarinol from the endemic Sardinian plant Seseli praecox. We show that Falcarinol exhibits binding affinity to both human CB receptors but selectively alkylates the anandamide binding site in the CB(1) receptor (K(i)=594nM), acting as covalent inverse agonist in CB(1) receptor-transfected CHO cells. Given the inherent instability of purified Falcarinol we repeatedly isolated this compound for biological characterization and one new polyyne was characterized. In human HaCaT keratinocytes Falcarinol increased the expression of the pro-allergic chemokines IL-8 and CCL2/MCP-1 in a CB(1) receptor-dependent manner. Moreover, Falcarinol inhibited the effects of anandamide on TNF-alpha stimulated keratinocytes. In vivo, Falcarinol strongly aggravated histamine-induced oedema reactions in skin prick tests. Both effects were also obtained with the CB(1) receptor inverse agonist rimonabant, thus indicating the potential role of the CB(1) receptor in skin immunopharmacology.
    CONCLUSIONS:
    Our data suggest anti-allergic effects of anandamide and that Falcarinol-associated dermatitis is due to antagonism of the CB(1) receptor in keratinocytes, leading to increased chemokine expression and aggravation of histamine action.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0917 mL 20.4583 mL 40.9165 mL 81.8331 mL 102.2913 mL
    5 mM 0.8183 mL 4.0917 mL 8.1833 mL 16.3666 mL 20.4583 mL
    10 mM 0.4092 mL 2.0458 mL 4.0917 mL 8.1833 mL 10.2291 mL
    50 mM 0.0818 mL 0.4092 mL 0.8183 mL 1.6367 mL 2.0458 mL
    100 mM 0.0409 mL 0.2046 mL 0.4092 mL 0.8183 mL 1.0229 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    人参环氧炔醇; Panaxydol CFN92797 72800-72-7 C17H24O2 = 260.4 20mg QQ客服:3257982914
    1,8-十七碳二烯-4,6-二炔-3,10-二醇; Panaxydiol CFN92798 708257-91-4 C17H24O2 = 260.4 5mg QQ客服:1413575084
    人参炔醇; Panaxyne CFN96202 122855-49-6 C14H20O2 = 220.3 5mg QQ客服:2056216494
    1,9-十五碳二烯-4,6-二炔-3,8-二醇8-乙酸酯; 8-Acetoxypentadeca-1,9Z-diene-4,6-diyn-3-ol CFN97743 41682-30-8 C17H22O3 = 274.36 5mg QQ客服:1413575084
    9,17-十八碳二烯-12,14-二炔-1,11,16-三醇; 9,17-Octadecadiene-12,14-diyne-1,11,16-triol CFN98061 211238-60-7 C18H26O3 = 290.4 5mg QQ客服:2159513211
    1-乙酰氧基-9,17-十八碳二烯-12,14-二炔-11,16-二醇; 1-Acetoxy-9,17-octadecadiene-12,14-diyne-11,16-diol CFN98068 213905-35-2 C20H28O4 = 332.4 5mg QQ客服:2932563308
    人参炔醇; Panaxynol CFN93212 81203-57-8 C17H24O = 244.4 5mg QQ客服:1413575084
    镰叶芹二醇; Falcarindiol CFN98220 225110-25-8 C17H24O2 = 260.4 20mg QQ客服:2056216494
    镰叶芹醇; Falcarinol CFN96027 21852-80-2 C17H24O = 244.4 5mg QQ客服:1457312923
    人参炔K; Ginsenoyne K CFN96044 141947-42-4 C17H24O3 = 276.4 5mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ1: 2056216494 ; QQ2: 3257982914
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产