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    产品编号 CFN93212
    CAS编号 81203-57-8
    分子式 = 分子量 C17H24O = 244.4
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Miscellaneous
    植物来源 The roots of Saposhnikovia divaricata.
    产品名称 产品编号 CAS编号 包装 QQ客服
    人参炔醇 CFN93212 81203-57-8 1mg QQ客服:2159513211
    人参炔醇 CFN93212 81203-57-8 5mg QQ客服:2159513211
    人参炔醇 CFN93212 81203-57-8 10mg QQ客服:2159513211
    人参炔醇 CFN93212 81203-57-8 20mg QQ客服:2159513211
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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  • 生物活性
    Description: Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation. Panaxynol has neuroprotective, and anti-proliferative effects, it induces neurite outgrowth in PC12D cells via cAMP- and MAP kinase-dependent mechanisms, and protects cortical neurons from ischemia-like injury by up-regulation of HIF-1alpha expression and inhibition of apoptotic cascade. Panaxynol has inhibitory effects on the proliferation of human pancreatic cancer cell PANC-1through inhibiting cell division and down-regulating Ki67 expression.
    Targets: Bcl-2/Bax | Caspase | HIF | ERK | cAMP | MAPK | PKA
    In vitro:
    Biochim Biophys Acta. 1989 Mar 24;990(3):315-20.
    Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng.[Pubmed: 2923911]
    The antiplatelet effect of panaxynol isolated from the diethyl ether layer was compared with those of ginsenosides from the butanol layer of Panax ginseng.
    Panaxynol (0.1 mg/ml) inhibited markedly the aggregation of washed platelets induced by collagen, arachidonic acid, ADP, ionophore A23187, PAF and thrombin while ginsenosides had no significant effect on the aggregation but ginsenoside Ro (1 mg/ml) inhibited the ATP release of platelets. Less inhibitory effect of panaxynol was observed in the aggregation of platelet-rich plasma. Thromboxane B2 formation of platelets was inhibited by panaxynol but not by ginsenosides. The antiplatelet effect of panaxynol was dependent on the incubation time and the aggregability of platelets inhibited by panaxynol could not easily be recovered after washing the platelets. In human platelet-rich plasma, panaxynol prevented secondary aggregation and completely blocked ATP release from platelets induced by epinephrine and ADP. Both panaxynol and ginsenoside Rg2 inhibited the rise of intracellular calcium caused by collagen.
    It is concluded that panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.
    Chem Biol Interact. 2006 Jan 5;159(1):58-64.
    Panaxynol induces neurite outgrowth in PC12D cells via cAMP- and MAP kinase-dependent mechanisms.[Pubmed: 16219303 ]
    Panaxynol, a polyacetylene ((3R)-heptadeca-1,9-diene-4,6-diyn-3-ol; syn. falcarinol), was isolated from the lipophilic fractions of Panax notoginseng, a Chinese traditional medicinal plant.
    In the present study, we reported the neurotrophic effects of panaxynol on PC12D cells and mechanism involved in neurite outgrowth of the cells. Panaxynol could morphologically promote neurite outgrowth in PC12D cells, concentration-dependently reduce cell division and up-regulate molecular marker (MAP1B) expression in PC12D cells. Panaxynol induces the elevation of intracellular cAMP in PC12D cells. The neurite outgrowth in PC12D cells induced by panaxynol could be inhibited by the protein kinase A inhibitor RpcAMPS and by MAP kinase kinase 1/2 inhibitor U0126.
    These observations reveal that panaxynol could induce the differentiation of PC12D cells in a process similar to but distinct from that of NGF and the panaxynol's effects were via cAMP- and MAP kinase-dependent mechanisms.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0917 mL 20.4583 mL 40.9165 mL 81.8331 mL 102.2913 mL
    5 mM 0.8183 mL 4.0917 mL 8.1833 mL 16.3666 mL 20.4583 mL
    10 mM 0.4092 mL 2.0458 mL 4.0917 mL 8.1833 mL 10.2291 mL
    50 mM 0.0818 mL 0.4092 mL 0.8183 mL 1.6367 mL 2.0458 mL
    100 mM 0.0409 mL 0.2046 mL 0.4092 mL 0.8183 mL 1.0229 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    党参炔醇; Lobetyol CFN92356 136171-87-4 C14H18O3 = 234.3 5mg QQ客服:2932563308
    党参炔苷; Lobetyolin CFN99104 136085-37-5 C20H28O8 = 396.43 20mg QQ客服:3257982914
    Lobetyolinin; Lobetyolinin CFN92357 142451-48-7 C26H38O13 = 558.6 5mg QQ客服:2159513211
    (3E,5E,11E)-tridecatriene-7,9-diyne-1,2-diacetate; (3E,5E,11E)-tridecatriene-7,9-diyne-1,2-diacetate CFN95191 N/A C17H18O4 = 286.3 5mg QQ客服:1457312923
    11-羟基茉莉酸; 11-Hydroxyjasmonic acid CFN99457 140447-14-9 C12H18O4 = 226.3 5mg QQ客服:3257982914
    12-羟基茉莉酸; 12-Hydroxyjasmonic acid CFN99460 140631-27-2 C12H18O4 = 226.3 5mg QQ客服:2056216494
    (R,E)-癸-2-烯-4,6-二炔-1,8-二醇; (R,E)-Deca-2-ene-4,6-diyne-1,8-diol CFN97502 931116-24-4 C10H12O2 = 164.2 5mg QQ客服:2159513211
    人参环氧炔醇; Panaxydol CFN92797 72800-72-7 C17H24O2 = 260.4 20mg QQ客服:1457312923
    1,8-十七碳二烯-4,6-二炔-3,10-二醇; Panaxydiol CFN92798 708257-91-4 C17H24O2 = 260.4 5mg QQ客服:2056216494
    人参炔醇; Panaxyne CFN96202 122855-49-6 C14H20O2 = 220.3 5mg QQ客服:1457312923





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