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    镰叶芹二醇

    Falcarindiol

    镰叶芹二醇
    产品编号 CFN98220
    CAS编号 225110-25-8
    分子式 = 分子量 C17H24O2 = 260.4
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Lipids
    植物来源 The roots of Angelica sinensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    镰叶芹二醇 CFN98220 225110-25-8 10mg QQ客服:3257982914
    镰叶芹二醇 CFN98220 225110-25-8 20mg QQ客服:3257982914
    镰叶芹二醇 CFN98220 225110-25-8 50mg QQ客服:3257982914
    镰叶芹二醇 CFN98220 225110-25-8 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sri Ramachandra University (India)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • University of Queensland (Australia)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Universidade do Porto (Portugal)
  • The University of Newcastle (Australia)
  • University of South Australia (Australia)
  • Melbourne University (Australia)
  • University of Illinois (USA)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Utrecht University (Netherlands)
  • Max Rubner-Institut (MRI) (Germany)
  • Copenhagen University (Denmark)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Asian Journal of Chemistry2014, 26(8):2425
  • Sci. Rep.2015, 14-23
  • Chem Biol Interact.2016, 258:59-68
  • Nat Plants.2016, 3:16205
  • Int J Mol Med.2016, 37(2):501-8
  • Sci Rep.2016, 6:25094
  • Onco Targets Ther.2017, 10:3467-3474
  • J Ethnopharmacol.2017, 198:87-90
  • Int J Anal Chem.2017, 2017:1254721
  • J Ethnopharmacol.2017, 209:305-316
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • Sci Rep. 2018, 10590
  • Molecules.2018, 23(10):E2638
  • Anat Rec2018, 24264
  • Sci Rep.2018, 8(1):12970
  • Molecules.2019, 24(4):E709
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • Saudi Pharm J2020, 10.1016
  • Molecules2020, 25(4):892
  • Dent Mater J.2020, 39(4):690-695
  • Metabolites.2020, 11(1):E11.
  • Int J Mol Sci.2020, 21(19):7209.
  • Analytical Letters.2020, doi 10.1008
  • ...
  • 生物活性
    Description: Falcarindiol has antimutagenic, neuroprotective, antifungal, anti-bacterial, and anticancer activities, it could be potentially used in food manufactures and cosmetology as preservative agents and biopesticides, or in medicine as new antibiotics. Falcarindiol has protective effects against CCl(4) toxicity, in part, the effects might be explained by anti-lipid peroxidation activity associated with the induction of the GSTs including GSTA4.
    Targets: GSK-3 | NO | NOS | NADPH-oxidase | P450 (e.g. CYP17)
    In vitro:
    Cell Death Dis. 2012 Aug 23;3:e376.
    The antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stress.[Pubmed: 22914324 ]
    Falcarindiol (FAD) is a natural polyyne with various beneficial biological activities.
    METHODS AND RESULTS:
    We show here that FAD preferentially kills colon cancer cells but not normal colon epithelial cells. Furthermore, FAD inhibits tumor growth in a xenograft tumor model and exhibits strong synergistic killing of cancer cells with 5-fluorouracil, an approved cancer chemotherapeutic drug. We demonstrate that FAD-induced cell death is mediated by induction of endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR). Decreasing the level of ER stress, either by overexpressing the ER chaperone protein glucose-regulated protein 78 (GRP78) or by knockout of components of the UPR pathway, reduces FAD-induced apoptosis. In contrast, increasing the level of ER stress by knocking down GRP78 potentiates FAD-induced apoptosis. Finally, FAD-induced ER stress and apoptosis is correlated with the accumulation of ubiquitinated proteins, suggesting that FAD functions at least in part by interfering with proteasome function, leading to the accumulation of unfolded protein and induction of ER stress. Consistent with this, inhibition of protein synthesis by cycloheximide significantly decreases the accumulation of ubiquitinated proteins and blocks FAD-induced ER stress and cell death.
    CONCLUSIONS:
    Taken together, our study shows that FAD is a potential new anticancer agent that exerts its activity through inducing ER stress and apoptosis.
    J. Agr. Food Chem., 1996, 44(11): 3444-8.
    Antimutagenic activity of falcarindiol from Peucedanum praeruptorum.[Reference: WebLink]
    A methanol extract from Peucedanum praeruptorum showed a suppressive effect on umu gene expression of the SOS response in Salmonella typhimurium TA1535/pSK1002 against the mutagen 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (furylfuramide).
    METHODS AND RESULTS:
    The methanol extract from P. praeruptorum was re-extracted with hexane, dichloromethane, n-butanol, and water, respectively. A suppressive compound in the hexane extract fraction was isolated by SiO2 column chromatography and identified as falcarindiol by EI-MS, IR, and 1H and 13C NMR spectroscopy. Falcarindiol exhibited an inhibition of the SOS-inducing activity of furylfuramide in the umu test. Gene expression was suppressed 75% at less than 0.15 μmol/mL, and the ID50 value was 0.10 μmol/mL. The diacetate compound of falcarindiol did not show any suppressive effect on the SOS induction of furylfuramide. Falcarindiol was also assayed with the mutagen 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), which requires liver-metabolizing enzymes, and showed a suppressive effect similar to that with furylfuramide. The falcarindiol ID50 value versus Trp-P-1 was 0.096 μmol/mL.
    CONCLUSIONS:
    The antimutagenic activities of falcarindiol and falcarindiol diacetate against furylfuramide and Trp-P-1 were tested by an Ames test using S. typhimurium TA100, which indicated that falcarindiol suppressed the mutagenicity of furylfuramide and Trp-P-1 and falcarindiol diacetate suppressed the mutagenicity of Trp-P-1.
    Planta Med., 1988, 54(1):36-7.
    Isolation of the Antifungal Compounds Falcarindiol and Sarisan from Heteromorpha trifoliata[Reference: WebLink]
    Leaves of Heteromorpha trifoliata (Umbelliferae) furnished the antifungal compounds falcarindiol and sarisan after flash and low-pressure liquid chromatographies.
    In vivo:
    J Agric Food Chem. 2013 Aug 7;61(31):7515-21.
    Inhibition of glycogen synthase kinase-3β by falcarindiol isolated from Japanese Parsley (Oenanthe javanica).[Pubmed: 23895038]

    METHODS AND RESULTS:
    A new biological activity of falcarindiol isolated from Japanese parsley (Oenanthe javanica) using the mutant yeast YNS17 strain (zds1Δ erg3Δ pdr1Δ pdr3Δ) was discovered as an inhibitor of glycogen synthase kinase-3β (GSK-3β). Falcarindiol inhibited GSK-3β in an ATP noncompetitive manner with a Ki value of 86.9 μM using a human enzyme and luminescent kinase assay platform. Falcarindiol also both suppressed gene expression of glucose-6-phosphatase (G6Pase) in rat hepatoma H4IIE cells and protected mouse neuroblastoma HT22 cells from glutamate-induced oxidative cell death at 10 μM. During an oral glucose tolerance test (OGTT), the blood glucose level was significantly decreased in the rats treated with oral administration of O. javanica extract containing falcarindiol (15 mg/kg).
    CONCLUSIONS:
    These findings indicate that Japanese parsley could be a useful food ingredient against type-2 diabetes and Alzheimer's disease.
    Biol Pharm Bull. 2011;34(3):371-8.
    Dietary diacetylene falcarindiol induces phase 2 drug-metabolizing enzymes and blocks carbon tetrachloride-induced hepatotoxicity in mice through suppression of lipid peroxidation.[Pubmed: 21372387]
    Falcarindiol is a diacetylenic natural product containing unique carbon-carbon triple bonds.
    METHODS AND RESULTS:
    Mice were orally administrated falcarindiol (100 mg/kg), and drug-metabolizing and antioxidant enzymes were monitored in several tissues of mice. Treatment with falcarindiol was found to increase glutathione S-transferase (GST) and NAD(P)H: quinone oxidoreductase 1 activities in liver, small intestine, kidney, and lung. No changes were observed in cytochrome P450 (CYP) 1A known to activate procarcinogens. Western blot analysis revealed that various GST subunits including GSTA4, which plays an important role in the detoxification of alkenals produced from lipid peroxides, were induced in liver, small intestine, and kidney of falcarindiol-treated mice. Additionally, we investigated the protective effects of falcarindiol against hepatotoxicity induced by carbon tetrachloride (CCl(4)) and the mechanism of its hepatoprotective effect. Pretreatment with falcarindiol prior to the administration of CCl(4) significantly suppressed both an increase in serum alanine transaminase/aspartate transaminase (ALT/AST) activity and an increase in hepatic thiobarbituric acid reactive substance levels without affecting CCl(4)-mediated degradation of CYP2E1. Formation of hexanoyl-lysine and 4-hydroxy-2(E)-nonenal-histidine adducts, lipid peroxidation biomarkers, in homogenates from the liver of CCl(4)-treated mice was decreased in the group of mice pretreated with falcarindiol.
    CONCLUSIONS:
    These results suggest that the protective effects of falcarindiol against CCl(4) toxicity might, in part, be explained by anti-lipid peroxidation activity associated with the induction of the GSTs including GSTA4.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.8402 mL 19.2012 mL 38.4025 mL 76.8049 mL 96.0061 mL
    5 mM 0.768 mL 3.8402 mL 7.6805 mL 15.361 mL 19.2012 mL
    10 mM 0.384 mL 1.9201 mL 3.8402 mL 7.6805 mL 9.6006 mL
    50 mM 0.0768 mL 0.384 mL 0.768 mL 1.5361 mL 1.9201 mL
    100 mM 0.0384 mL 0.192 mL 0.384 mL 0.768 mL 0.9601 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    9,17-十八碳二烯-12,14-二炔-1,11,16-三醇; 9,17-Octadecadiene-12,14-diyne-1,11,16-triol CFN98061 211238-60-7 C18H26O3 = 290.4 5mg QQ客服:2159513211
    1-乙酰氧基-9,17-十八碳二烯-12,14-二炔-11,16-二醇; 1-Acetoxy-9,17-octadecadiene-12,14-diyne-11,16-diol CFN98068 213905-35-2 C20H28O4 = 332.4 5mg QQ客服:1457312923
    人参炔醇; Panaxynol CFN93212 81203-57-8 C17H24O = 244.4 5mg QQ客服:2932563308
    镰叶芹二醇; Falcarindiol CFN98220 225110-25-8 C17H24O2 = 260.4 20mg QQ客服:2932563308
    镰叶芹醇; Falcarinol CFN96027 21852-80-2 C17H24O = 244.4 5mg QQ客服:1413575084
    人参炔K; Ginsenoyne K CFN96044 141947-42-4 C17H24O3 = 276.4 5mg QQ客服:2159513211
    党参炔醇; Lobetyol CFN92356 136171-87-4 C14H18O3 = 234.3 5mg QQ客服:1413575084
    党参炔苷; Lobetyolin CFN99104 136085-37-5 C20H28O8 = 396.43 20mg QQ客服:2056216494
    Lobetyolinin; Lobetyolinin CFN92357 142451-48-7 C26H38O13 = 558.6 5mg QQ客服:2159513211
    (3E,5E,11E)-tridecatriene-7,9-diyne-1,2-diacetate; (3E,5E,11E)-tridecatriene-7,9-diyne-1,2-diacetate CFN95191 N/A C17H18O4 = 286.3 5mg QQ客服:2056216494

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