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  • 齿孔酸; 齿孔菌酸

    Eburicoic acid

    齿孔酸; 齿孔菌酸
    产品编号 CFN90414
    CAS编号 560-66-7
    分子式 = 分子量 C31H50O3 = 470.73
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Wolfiporia cocos (Schw.) Ryv.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    齿孔酸; 齿孔菌酸 CFN90414 560-66-7 1mg QQ客服:2056216494
    齿孔酸; 齿孔菌酸 CFN90414 560-66-7 5mg QQ客服:2056216494
    齿孔酸; 齿孔菌酸 CFN90414 560-66-7 10mg QQ客服:2056216494
    齿孔酸; 齿孔菌酸 CFN90414 560-66-7 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Texas A&M University (USA)
  • Univerzita Karlova v Praze (Czech Republic)
  • Northeast Normal University Changchun (China)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Semmelweis Unicersity (Hungary)
  • Universidade Católica Portuguesa (Portugal)
  • Ateneo de Manila University (Philippines)
  • University of Mysore (India)
  • Florida A&M University (USA)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Universidade da Beira Interior (Germany)
  • University of Maryland (USA)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • University of Hertfordshire (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Wageningen University & Research2018, January 2018
  • Int J Cosmet Sci.2022, doi:10.1111/ics.12827.
  • Molecules.2016, 21(6)
  • Exp Mol Med.2020, 52(4):629-642.
  • Oncol Rep.2021, 46(2):166.
  • Phytochem Anal.2023, pca.3305.
  • Eur J Pharmacol.2021, 906:174220.
  • J Ethnopharmacol.2024, 318:116863.
  • Int J Mol Sci.2022, 23(23):14545.
  • Foods.2021, 10(11):2754.
  • Acta horticulturae2017, 1158:257-268
  • Int J Nanomedicine.2022, 17:6513-6525.
  • Process Biochemistry2019, 87:213-220
  • Molecules.2021, 26(9):2802.
  • Cell Prolif.2021, 54(8):e13083.
  • Molecules.2021, 26(9):2765.
  • J AOAC Int.2023, 106(1):56-64.
  • Eur Rev Med Pharmacol Sci.2020, 24(9):5127-5139.
  • Oxid Med Cell Longev.2020, 2020:8887251.
  • Journal of Research in Pharmacy.2022, 26(6):p1752-1757.
  • PLoS One.2018, 13(3):e0193386
  • Mol Cell.2017, 68(4):673-685
  • Plant Physiol Biochem.2019, 144:355-364
  • ...
  • 生物活性
    Description: Eburicoic acid and TR2 have anti-inflammatory activity, the mechanism is related to the decrease of inflammatory cytokines and an increase of antioxidant enzyme activity, they protect the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms. Eburicoic acid has significant anti-liver cancer effects and more distinctive mechanisms.
    Targets: SOD | NO | TNF-α | NOS | COX | P450 (e.g. CYP17) | IL Receptor
    In vivo:
    J Agric Food Chem. 2013 May 29;61(21):5064-71.
    Analgesic and anti-inflammatory bioactivities of eburicoic acid and dehydroeburicoic acid isolated from Antrodia camphorata on the inflammatory mediator expression in mice.[Pubmed: 23495748 ]
    Eburicoic acid (TR1) and dehydroEburicoic acid (TR2), an active ingredient from Antrodia camphorata (AC) solid-state culture, were evaluated for analgesic and anti-inflammatory effects.
    METHODS AND RESULTS:
    Treatment with Eburicoic acid and TR2 significantly inhibited a number of acetic acid-induced writhing responses and formalin-induced pain in the late phase. In the anti-inflammatory test, Eburicoic acid and TR2 decreased paw edema at the fourth and fifth hour after λ-carrageenan (Carr) administration and increased the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the paw edema tissue. We also demonstrated that Eburicoic acid and TR2 significantly attenuated the malondialdehyde (MDA), nitric oxide (NO), tumor necrosis factor (TNF-α), and interleukin-1β (IL-1β) levels in either edema paw or serum at the fifth hour after Carr injection. Western blotting revealed that Eburicoic acid and TR2 decreased Carr-induced inducible nitric oxide synthase (iNOS) and cycloxyclase (COX-2) expressions at the fifth hour in paw edema. Treatment with TR1 and TR2 also diminished neutrophil infiltration into the paw edema at the fifth hour.
    CONCLUSIONS:
    The present study suggests that the anti-inflammatory mechanisms of Eburicoic acid and TR2 might be related to the decrease of inflammatory cytokines and an increase of antioxidant enzyme activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1244 mL 10.6218 mL 21.2436 mL 42.4872 mL 53.109 mL
    5 mM 0.4249 mL 2.1244 mL 4.2487 mL 8.4974 mL 10.6218 mL
    10 mM 0.2124 mL 1.0622 mL 2.1244 mL 4.2487 mL 5.3109 mL
    50 mM 0.0425 mL 0.2124 mL 0.4249 mL 0.8497 mL 1.0622 mL
    100 mM 0.0212 mL 0.1062 mL 0.2124 mL 0.4249 mL 0.5311 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-表去氢茯苓酸; 3-Epidehydropachymic acid CFN92738 168293-15-0 C33H50O5 = 526.8 5mg QQ客服:3257982914
    6alpha-羟基去氢茯苓酸; 6alpha-Hydroxydehydropachymic acid CFN95412 176390-67-3 C33H50O6 = 542.8 5mg QQ客服:1457312923
    过氧去氢土莫酸; Peroxydehydrotumulosic acid CFN92836 943225-53-4 C31H46O6 = 514.7 5mg QQ客服:3257982914
    多孔菌酸C; Polyporenic acid C CFN92739 465-18-9 C31H46O4 = 482.7 10mg QQ客服:2056216494
    16-O-Acetylpolyporenic acid C; 16-O-Acetylpolyporenic acid C CFN96159 2535-06-0 C33H48O5 = 524.7 5mg QQ客服:1413575084
    6α-羟基猪苓酸C; 6alpha-Hydroxypolyporenic acid C CFN92741 24513-63-1 C31H46O5 = 498.7 5mg QQ客服:1413575084
    新化合物15; New compound 15 CFN95413 N/A C31H46O6 = 514.7 5mg QQ客服:3257982914
    茯苓新酸A; Poricoic acid A(F) CFN92838 137551-38-3 C31H46O5 = 498.7 20mg QQ客服:3257982914
    茯苓酸AM; Poricoic acid AM CFN91538 151200-92-9 C32H48O5 = 512.7 5mg QQ客服:215959384
    Poricoic acid AE ; Poricoic acid AE CFN96980 1159753-88-4 C33H50O5 = 526.75 5mg QQ客服:2159513211

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