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  • Diepiserratenediol

    Diepiserratenediol

    Diepiserratenediol
    产品编号 CFN89141
    CAS编号 3604-92-0
    分子式 = 分子量 C30H50O2 = 442.72
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The whole plants of Lycopodium japonicum Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Diepiserratenediol CFN89141 3604-92-0 1mg QQ客服:2056216494
    Diepiserratenediol CFN89141 3604-92-0 5mg QQ客服:2056216494
    Diepiserratenediol CFN89141 3604-92-0 10mg QQ客服:2056216494
    Diepiserratenediol CFN89141 3604-92-0 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sant Gadge Baba Amravati University (India)
  • Seoul National University (Korea)
  • University of Canterbury (New Zealand)
  • Colorado State University (USA)
  • Monash University (Australia)
  • Mahidol University (Thailand)
  • Nanjing University of Chinese Medicine (China)
  • Chinese University of Hong Kong (China)
  • Siksha O Anusandhan University (India)
  • The University of Newcastle (Australia)
  • Technical University of Denmark (Denmark)
  • Universite de Lille1 (France)
  • Sapienza University of Rome (Italy)
  • University of Parma (Italy)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Korean Med Ophthalmol Otolaryngol Dermatol2023, 36(1):21-39.
  • Adaptive Medicine 2020, 12(1): 4-10
  • Food Chem.2020, 313:126079
  • Industrial Crops and Products2017, 95:286-295
  • Processes2022, 10(10), 2008.
  • Analytical methods2019, 11(6)
  • Appl. Sci. 2021, 11(23),11099.
  • Metabolites2023, 13(1), 3.
  • J Sep Sci.2021, 44(22):4064-4081.
  • J Sci Food Agric.2018, 98(3):1153-1161
  • Heliyon.2022, e12337.
  • Cell Rep.2020, 32(11):108158.
  • New Zealand J. Forestry Sci.2014, 44:17
  • Nat Prod Commun.2017, 12(5):771-778
  • J Pharm Biomed Anal.2022, 207:114398.
  • Theoretical and Experimental Plant Physiology 2022, 34,53-62
  • Molecules 2021, 26(4),1092.
  • Braz J Biol.2023, 82:e266573.
  • Mol Microbiol.2019, 112(1):317-332
  • Neurochem Int.2020, 133:104629
  • Food Res Int.2017, 96:40-45
  • BMC Complement Altern Med.2019, 19(1):325
  • Neuropharmacology2019, 151437
  • ...
  • 生物活性
    Description: Diepiserratenediol has potential activity to inhibit tumor promotion, it shows potent inhibitory effects on EBV-EA induction (100% inhibition at 1000 mol ratio/TPA).
    In vitro:
    Cancer Lett. 2004 Oct 28;214(2):149-56.
    Cancer chemopreventive activity of 3beta-methoxyserrat-14-en-21beta-ol and several serratane analogs on two-stage mouse skin carcinogenesis.[Pubmed: 15363540]
    3beta-Methoxyserrat-14-en-21beta-ol (1) and 3alpha-methoxyserrat-14-en-21beta-ol (2) are the most abundant triterpenoids from two Picea plants, Picea jezoensis (Sieb. et Zucc.) Carr. var. jezoensis and P. jezoensis (Sieb. et Zucc.) Carr. hondoensis (Mayr) Rehder, and the total yield of 1 and 2 reach over 1/3 of the chloroform extract of the above two plants.
    METHODS AND RESULTS:
    This study deals with the potential of anti-tumor promoting activity of 1 and results of the assay of 22 synthetic serratane-type triterpenoids (6)-(27) derived from 1, 2, 21-episerratenediol (3), Diepiserratenediol (4) and 13alpha,14alpha-epoxy-3beta-methoxyserratan-21beta-ol (5) to discuss the structure-activity relationship. As a preliminary evaluation of their potential to inhibit tumor promotion, the inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) were used. All compounds except for 12 and 19 showed potent inhibitory effects on EBV-EA induction (100% inhibition at 1000 mol ratio/TPA), their effects being stronger than that of a positive control oleanolic acid. Compounds 1, 13, 14, 18, 20 and 26 were selected to examine the effect on the in vivo two-stage mouse skin carcinogenesis test induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.
    CONCLUSIONS:
    The most abundant triterpenoid 1 and the synthetic compounds 13 and 14 were found to exhibit the excellent anti-tumor promoting activity in the in vivo carcinogenesis test, and compounds 18, 20 and 26 also showed strong inhibitory effects.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2588 mL 11.2938 mL 22.5876 mL 45.1753 mL 56.4691 mL
    5 mM 0.4518 mL 2.2588 mL 4.5175 mL 9.0351 mL 11.2938 mL
    10 mM 0.2259 mL 1.1294 mL 2.2588 mL 4.5175 mL 5.6469 mL
    50 mM 0.0452 mL 0.2259 mL 0.4518 mL 0.9035 mL 1.1294 mL
    100 mM 0.0226 mL 0.1129 mL 0.2259 mL 0.4518 mL 0.5647 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Tetrahymanone; Tetrahymanone CFN96623 17822-06-9 C30H50O = 426.72 5mg QQ客服:2056216494
    酮基哈共醇; Ketohakonanol CFN89135 18004-20-1 C29H48O2 = 428.70 5mg QQ客服:2056216494
    Diepiserratenediol; Diepiserratenediol CFN89141 3604-92-0 C30H50O2 = 442.72 5mg QQ客服:215959384
    21-表千层塔烯二醇; 21-Episerratenediol CFN99495 1449-06-5 C30H50O2 = 442.7 5mg QQ客服:2159513211
    马尾杉醇C; Phlegmanol C CFN99371 1260-05-5 C32H52O3 = 484.8 5mg QQ客服:2159513211
    千层塔烯二醇; 锯齿石松烯二醇; 山芝烯二醇; Serratenediol CFN98216 2239-24-9 C30H50O2 = 442.7 5mg QQ客服:2159513211
    二乙酸山芝烯二醇酯; Serratenediol diacetate CFN98339 27832-84-4 C34H54O4 = 526.8 5mg QQ客服:1413575084
    21-表山芝烯三醇; 21-Episerratriol CFN98264 24513-57-3 C30H50O3 = 458.7 5mg QQ客服:3257982914
    山芝烯三醇; Serratriol CFN99446 13956-52-0 C30H50O3 = 458.7 5mg QQ客服:3257982914
    石松醇; Lycoclavanol CFN99445 13956-51-9 C30H50O3 = 458.7 5mg QQ客服:1457312923

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