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  • 5-羟色胺酸

    5-Hydroxytryptophan

    5-羟色胺酸
    产品编号 CFN99742
    CAS编号 56-69-9
    分子式 = 分子量 C11H12N2O3 = 220.23
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Alkaloids
    植物来源 The seeds of Griffonia simplicifolia
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    5-羟色胺酸 CFN99742 56-69-9 10mg QQ客服:1457312923
    5-羟色胺酸 CFN99742 56-69-9 20mg QQ客服:1457312923
    5-羟色胺酸 CFN99742 56-69-9 50mg QQ客服:1457312923
    5-羟色胺酸 CFN99742 56-69-9 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Auckland (New Zealand)
  • Weizmann Institute of Science (Israel)
  • Ain Shams University (Egypt)
  • Max-Planck-Insitut (Germany)
  • Wageningen University (Netherlands)
  • University of Queensland (Australia)
  • Rio de Janeiro State University (Brazil)
  • National Cancer Institute (USA)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • MTT Agrifood Research Finland (Finland)
  • University of Maryland School of Medicine (USA)
  • Srinakharinwirot University (Thailand)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2019, 24(11):E2102
  • LWT2021, 138:110630.
  • Applied Biological Chemistry2020, 63:37.
  • J Pharmaceut Biomed2020, 182:113110
  • Thorac Cancer.2023, 14(21):2007-2017.
  • Pak J Pharm Sci.2019, 32(6)
  • Acta Agriculturae Scandinavica2015, 381-383
  • Journal of Food and Drug Analysis2023, 31(3), 9.
  • Mol Plant Pathol.2022, 10.1111:mpp.13280.
  • Int J Mol Sci.2021, 22(21):11836.
  • Food Funct.2020, 11(2):1322-1333.
  • J Nat Med.2017, 71(4):745-756
  • Int J Mol Sci.2020, 21(19),7070.
  • JPC-Journal of Planar Chromatography2023, 36:179-190
  • Pol J Microbiol.2021, 70(1):117-130.
  • Curr Issues Mol Biol.2022, 44(5):2300-2308.
  • Kangwon National University2022, 37(1):29-37
  • J Cancer.2019, 10(23):5843-5851
  • Oncol Rep.2021, 46(1):143.
  • Food Chem.2017, 221:1135-1144
  • Korean Journal of Medicinal Crop Science2018, 26(5):382-390
  • Front Pharmacol.2022, 13:906763.
  • J Agric Food Chem.2021, 69(11):3496-3510.
  • ...
  • 生物活性
    Description: 5-Hydroxytryptophan (5-HTP) is the precursor of serotonin , has been widely used as a dietary supplement to raise serotonin level, it is an effective drug against depression, insomnia, obesity, chronic headaches, etc. 5-HTP supplementation can inhibit endothelial serotonylation, leukocyte recruitment, and allergic inflammation, it also can reduce the symptoms of anxiety/depression of that patients with allergy/asthma. 5-HTP may be involved in inducing the female to stay in copula and delay egg-laying to prevent re-mating of the female.
    Targets: NF-kB | IL Receptor | TNF-α
    In vitro:
    Am J Physiol Lung Cell Mol Physiol. 2012 Oct 15; 303(8): L642–L660.
    Inhibition of allergic inflammation by supplementation with 5-hydroxytryptophan[Pubmed: 22842218]
    Clinical reports indicate that patients with allergy/asthma commonly have associated symptoms of anxiety/depression. Anxiety/depression can be reduced by 5-Hydroxytryptophan (5-HTP) supplementation. However, it is not known whether 5-HTP reduces allergic inflammation. Therefore, we determined whether 5-HTP supplementation reduces allergic inflammation. We also determined whether 5-HTP decreases passage of leukocytes through the endothelial barrier by regulating endothelial cell function. For these studies, C57BL/6 mice were supplemented with 5-HTP, treated with ovalbumin fraction V (OVA), house dust mite (HDM) extract, or IL-4, and examined for allergic lung inflammation and OVA-induced airway responsiveness.
    METHODS AND RESULTS:
    To determine whether 5-HTP reduces leukocyte or eosinophil transendothelial migration, endothelial cells were pretreated with 5-HTP, washed and then used in an in vitro transendothelial migration assay under laminar flow. Interestingly, 5-HTP reduced allergic lung inflammation by 70–90% and reduced antigen-induced airway responsiveness without affecting body weight, blood eosinophils, cytokines, or chemokines. 5-HTP reduced allergen-induced transglutaminase 2 (TG2) expression and serotonylation (serotonin conjugation to proteins) in lung endothelial cells. Consistent with the regulation of endothelial serotonylation in vivo, in vitro pretreatment of endothelial cells with 5-HTP reduced TNF-α-induced endothelial cell serotonylation and reduced leukocyte transendothelial migration. Furthermore, eosinophil and leukocyte transendothelial migration was reduced by inhibitors of transglutaminase and by inhibition of endothelial cell serotonin synthesis, suggesting that endothelial cell serotonylation is key for leukocyte transendothelial migration.
    CONCLUSIONS:
    In summary, 5-HTP supplementation inhibits endothelial serotonylation, leukocyte recruitment, and allergic inflammation. These data identify novel potential targets for intervention in allergy/asthma.
    In vivo:
    Arch Oral Biol. 2015 May;60(5):789-98.
    Oral administration of 5-hydroxytryptophan aggravated periodontitis-induced alveolar bone loss in rats.[Pubmed: 25766472]
    5-Hydroxytryptophan (5-HTP) is the precursor of serotonin and 5-Hydroxytryptophan has been widely used as a dietary supplement to raise serotonin level. Serotonin has recently been discovered to be a novel and important player in bone metabolism. As peripheral serotonin negatively regulates bone, the regular take of 5-Hydroxytryptophan may affect the alveolar bone metabolism and therefore influence the alveolar bone loss induced by periodontitis. The aim of this study was to investigate the effect of 5-Hydroxytryptophan on alveolar bone destruction in periodontitis.
    METHODS AND RESULTS:
    Male Sprague-Dawley rats were randomly divided into the following four groups: (1) the control group (without ligature); (2) the 5-HTP group (5-Hydroxytryptophan at 25 mg/kg/day without ligature); (3) the L group (ligature+saline placebo); and (4) the L+5-Hydroxytryptophan group (ligature+5-Hydroxytryptophan at 25 mg/kg/day). Serum serotonin levels were determined by ELISA. The alveolar bones were evaluated with micro-computed tomography and histology. Tartrate-resistant acid phosphatase staining was used to assess osteoclastogenesis. The receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG) expression in the periodontium as well as the interleukin-6 positive osteocytes were analysed immunohistochemically. 5-Hydroxytryptophan significantly increased serum serotonin levels. In rats with experimental periodontitis, 5-Hydroxytryptophan increased alveolar bone resorption and worsened the micro-structural destruction of the alveolar bone. 5-Hydroxytryptophan also stimulated osteoclastogenesis and increased RANKL/OPG ratio and the number of IL-6 positive osteocytes. However, 5-Hydroxytryptophan treatment alone did not cause alveolar bone loss in healthy rats.
    CONCLUSIONS:
    The present study showed that 5-Hydroxytryptophan aggravated alveolar bone loss, deteriorated alveolar bone micro-structure in the presence of periodontitis, which suggests 5-Hydroxytryptophan administration may increase the severity of periodontitis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.5407 mL 22.7035 mL 45.4071 mL 90.8141 mL 113.5177 mL
    5 mM 0.9081 mL 4.5407 mL 9.0814 mL 18.1628 mL 22.7035 mL
    10 mM 0.4541 mL 2.2704 mL 4.5407 mL 9.0814 mL 11.3518 mL
    50 mM 0.0908 mL 0.4541 mL 0.9081 mL 1.8163 mL 2.2704 mL
    100 mM 0.0454 mL 0.227 mL 0.4541 mL 0.9081 mL 1.1352 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    顺-N-阿魏羟色胺; cis-Moschamine CFN94007 193224-24-7 C20H20N2O4 = 352.39 5mg QQ客服:1457312923
    N-(p-香豆酰)-羟色胺; N-(p-Coumaroyl) serotonin CFN91127 68573-24-0 C19H18N2O3 = 322.4 5mg QQ客服:3257982914
    1,2,3,4-四羟基去甲哈尔满-1-酮; 1,2,3,4-Tetrahydronorharman-1-one CFN92785 17952-82-8 C11H10N2O = 186.2 5mg QQ客服:3257982914
    Cuscutamine; Cuscutamine CFN95323 122170-93-8 C15H14N2O3 = 270.3 5mg QQ客服:1413575084
    1-甲氧基吲哚-3-羧酸; 1-Methoxyindole-3-carboxylic acid CFN96036 91913-76-7 C10H9NO3 = 191.2 5mg QQ客服:3257982914
    1-甲氧基-3-吲哚乙腈; Caulilexin C CFN96052 30536-48-2 C11H10N2O = 186.2 5mg QQ客服:215959384
    N-甲基-5-羟色胺; N-Methylserotonin CFN91557 1134-01-6 C11H14N2O = 190.2 5mg QQ客服:2056216494
    芦竹碱; Gramine CFN98111 87-52-5 C11H14N2 = 174.25 20mg QQ客服:1413575084
    蟾蜍色胺; Bufotenine CFN91165 487-93-4 C12H16N2O = 204.3 10mg QQ客服:1457312923
    华蟾蜍色胺; Cinobufotenine CFN91166 60657-23-0 C13H19N2O = 219.3 10mg QQ客服:2056216494

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