beta-乳香酸

Beta-boswellic acid

	产品编号	CFN90221
	CAS编号	631-69-6
	分子式 = 分子量	C₃₀H₄₈O₃ = 456.70
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The herbs of Boswellia carterii Birdw.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
beta-乳香酸	CFN90221	631-69-6	10mg	QQ客服：215959384
beta-乳香酸	CFN90221	631-69-6	20mg	QQ客服：215959384
beta-乳香酸	CFN90221	631-69-6	50mg	QQ客服：215959384
beta-乳香酸	CFN90221	631-69-6	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Donald Danforth Plant Science Center (USA)

University of Maryland School of Medicine (USA)

Sapienza University of Rome (Italy)

Universidade da Beira Interior (Germany)

The University of Newcastle (Australia)

Max Rubner-Institut (MRI) (Germany)

Washington State University (USA)

Instituto Politécnico de Bragan?a (Portugal)

Monash University Malaysia (Malaysia)

Leibniz Institute of Plant Biochemistry (Germany)

Research Unit Molecular Epigenetics (MEG) (Germany)

St. Jude Children Research Hospital (USA)

University of Illinois at Chicago (USA)

Colorado State University (USA)

More...

Description:

Beta-boswellic acid and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities. Beta-boswellic acid can significantly enhance neurite outgrowth, branching, and tubulin polymerization dynamics.

Targets:

IL Receptor

In vitro:

Neurol Sci. 2010 Jun;31(3):315-20.

The enhancement effect of beta-boswellic acid on hippocampal neurites outgrowth and branching (an in vitro study).[Pubmed: 20217445]

Increasing evidences implicate impairment of axonal integrity in mechanisms underlying neurodegenerative disorders. Beta-boswellic acid (BBA) is the major component of Boswellia serrata gum. This resin has long been used in Ayurveda (India's traditional medicine) to prevent amnesia.
METHODS AND RESULTS:
In this study, the effect of BBA was examined on neurites outgrowth and branching as well as on polymerization dynamics of tubulin. The morphometric parameters (axonal length and neuritis branching) were examined microscopically after treating the hippocampal cells with BBA. Also the assembly process of tubulin was assessed using UV/V is spectrophotometer through following of absorbance at 350 nm.
CONCLUSIONS:
The results revealed that BBA could significantly enhance neurite outgrowth, branching, and tubulin polymerization dynamics. The obtained results suggest that enhancing effect of BBA on microtubule polymerization kinetics might be the origin of increasing axonal outgrowth and branching.

In vivo:

BioFactors (Oxford, England)2000, 13(1-4):225-230

Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid.[Reference: WebLink]

Boswellin (BE), a methanol extract of the gum resin exudate of Boswellia serrata, contains naturally occurring triterpenoids, Beta-boswellic acid and its structural related derivatives, has been used as a traditional medicine for the treatment of inflammatory and arthritic diseases.
METHODS AND RESULTS:
Topical application of BE to the backs of mice markedly inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in skin inflammation, epidermal proliferation, the number of epidermal cell layers, and tumor promotion in 7,12-dimethylbenz[a]anthracene (DMBA)-initiated mice. Feeding 0.2% of BE in the diet to CF-1 mice for 10-24 weeks reduced the accumulation of parametrial fat pad weight under the abdomen, and inhibited azoxymethane (AOM)-induced formation of aberrant crypt foci (ACF) by 46%. Addition of pure Beta-boswellic acid, 3-O-acetyl-Beta-boswellic acid, 11-keto-Beta-boswellic acid or 3-O-acetyl-11-keto-Beta-boswellic acid to human leukemia HL-60 cell culture inhibited DNA synthesis in HL-60 cells in a dose-dependent manner with IC50 values ranging from 0.6 to 7.1 microM.
CONCLUSIONS:
These results indicate that Beta-boswellic acid and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
3-O-乙酰基 9,11-脱氢 β-乳香酸; 3-O-Acetyl 9,11-dehydro beta-boswellic acid	CFN70260	122651-20-1	C₃₂H₄₈O₄ = 496.7	5mg	QQ客服：2056216494
栎樱酸; Roburic acid	CFN98562	6812-81-3	C₃₀H₄₈O₂ = 440.71	20mg	QQ客服：2159513211
野甘草酸; Dulcioic acid	CFN97681	78516-69-5	C₃₀H₄₈O₃ = 456.71	5mg	QQ客服：2056216494
Triptocallic acid A; Triptocallic acid A	CFN99881	190906-61-7	C₃₀H₄₈O₄ = 472.7	5mg	QQ客服：1457312923
22-羟基-3-氧代乌苏-12-烯-30-酸; 22-Hydroxy-3-oxo-12-ursen-30-oic acid	CFN99821	173991-81-6	C₃₀H₄₆O₄ = 470.7	5mg	QQ客服：2159513211
beta-乳香酸; Beta-boswellic acid	CFN90221	631-69-6	C₃₀H₄₈O₃ = 456.70	20mg	QQ客服：1413575084
3-乙酰基-beta-乳香酸; 3-O-Acetyl-beta-boswellic acid	CFN90530	5968-70-7	C₃₂H₅₀O₄ = 498.74	10mg	QQ客服：3257982914
11-酮基-beta-乳香酸; 11-Keto-beta-boswellic acid	CFN90152	17019-92-0	C₃₀H₄₆O₄ = 470.68	20mg	QQ客服：1413575084
乙酰基-11-酮基-beta-乳香酸; 3-O-Acetyl-11-keto-beta-boswellic acid	CFN90531	67416-61-9	C₃₂H₄₈O₅ = 512.72	20mg	QQ客服：1457312923
9,11-去氢-beta-乳香酸; 9,11-Dehydro-beta-boswellic acid	CFN95335	471-65-8	C₃₀H₄₆O₃ = 454.7	5mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1896 mL	10.9481 mL	21.8962 mL	43.7924 mL	54.7405 mL
5 mM	0.4379 mL	2.1896 mL	4.3792 mL	8.7585 mL	10.9481 mL
10 mM	0.219 mL	1.0948 mL	2.1896 mL	4.3792 mL	5.4741 mL
50 mM	0.0438 mL	0.219 mL	0.4379 mL	0.8758 mL	1.0948 mL
100 mM	0.0219 mL	0.1095 mL	0.219 mL	0.4379 mL	0.5474 mL

beta-乳香酸

Beta-boswellic acid

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