仙鹤草酚B

Agrimol B

	产品编号	CFN98169
	CAS编号	55576-66-4
	分子式 = 分子量	C₃₇H₄₆O₁₂ = 682.75
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The herbs of Agrimonia pilosa Ledeb.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
仙鹤草酚B	CFN98169	55576-66-4	10mg	QQ客服：215959384
仙鹤草酚B	CFN98169	55576-66-4	20mg	QQ客服：215959384
仙鹤草酚B	CFN98169	55576-66-4	50mg	QQ客服：215959384
仙鹤草酚B	CFN98169	55576-66-4	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Kyoto University (Japan)

University of Perugia (Italy)

National Chung Hsing University (Taiwan)

Chinese University of Hong Kong (China)

Max Rubner-Institut (MRI) (Germany)

University of Beira Interior (Portugal)

University of Limpopo (South Africa)

Georgia Institute of Technology (USA)

Sri Ramachandra University (India)

Sant Gadge Baba Amravati University (India)

Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)

Uniwersytet Jagielloński w Krakowie (Poland)

Monash University Malaysia (Malaysia)

Shanghai University of TCM (China)

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Description:

Agrimol B has antibacterial activity against Pseudomonas syringae pv. lacrymans (bacterial leaf spot pathogen), Ralstonia solanacearum (tomato bacterial wilt pathogen) and Pseudomonas syringae pv. tabaci (Tobacco wild fire pathogen). Agrimol B has a therapeutic potential on alleviating obesity, through modulation of SIRT1-PPARγ signal pathway.

Targets:

PPAR | Antifection

In vitro:

The Korean Journal of Pesticide Science,2006, 10(3):230-6.

Antibacterial Activities against Plant Pathogens and Identification of Agrimol B from Agrimonia pilosa LEDEB.[Reference: WebLink]

METHODS AND RESULTS:
Eighty-five percent methanol extract of Agrimonia pilosa has antibacterial activity against Pseudomonas syringae pv. lacrymans (bacterial leaf spot pathogen), Ralstonia solanacearum (tomato bacterial wilt pathogen) and Pseudomonas syringae pv. tabaci (Tobacco wild fire pathogen.). The active substance was purified by silica gel column chromatography and HPLC. The molecular weight of the active compound was determined by LC-Mass as 687.2.
CONCLUSIONS:
With NMR analysis, the active substance was identified as Agrimol B.

Biochem Biophys Res Commun . 2016 Aug 26;477(3):454-60.

Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway[Pubmed: 27320865]

Abstract Studies of human genetics have implicated the role of SIRT1 in regulating obesity, insulin resistance, and longevity. These researches motivated the identification of novel SIRT1 activators. The current study aimed to investigate the potential efficacy of agrimol B, a polyphenol derived from Agrimonia pilosa Ledeb., on mediating SIRT1 activity and fat metabolism. Results showed that agrimol B significantly induced cytoplasm-to-nucleus shuttle of SIRT1. Furthermore, we confirmed that agrimol B dramatically inhibited 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. Consequently, adipogenesis was blocked by treatment of agrimol B at the early stage of differentiation in a dose-dependent manner, the IC50 value was determined as 3.35 ± 0.32 μM. Taken together, our data suggest a therapeutic potential of agrimol B on alleviating obesity, through modulation of SIRT1-PPARγ signal pathway. Keywords: Agrimol B; Agrimonia pilosa Ledeb.; Lipid droplet; Obesity; PPARγ; SIRT1.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
二去甲基伪绵马素AA; Didemethylpseudoaspidin AA	CFN92877	142382-28-3	C₁₉H₂₀O₈ = 376.4	5mg	QQ客服：3257982914
伪绵马素; Pseudoaspidin	CFN90684	478-28-4	C₂₅H₃₂O₈ = 460.5	20mg	QQ客服：3257982914
白绵马素AA; Albaspidin AA	CFN98474	3570-40-9	C₂₁H₂₄O₈ = 404.4	5mg	QQ客服：2159513211
白绵马素AP; Albaspidin AP	CFN90252	59092-91-0	C₂₂H₂₆O₈ = 418.44	5mg	QQ客服：1413575084
绵马酸ABA; Filixic acid ABA	CFN99573	38226-84-5	C₃₂H₃₆O₁₂ = 612.63	5mg	QQ客服：1413575084
仙鹤草酚B; Agrimol B	CFN98169	55576-66-4	C₃₇H₄₆O₁₂ = 682.75	20mg	QQ客服：2159513211
绵马贯众素ABBA; Dryocrassin ABBA	CFN99519	12777-70-7	C₄₃H₄₈O₁₆ = 820.81	5mg	QQ客服：215959384
棉酚; Gossypol	CFN90561	303-45-7	C₃₀H₃₀O₈ = 518.56	20mg	QQ客服：1457312923
醋酸棉酚; Acetate gossypol	CFN98529	12542-36-8	C₃₂H₃₄O₁₀ = 578.61	20mg	QQ客服：215959384
Sideroxylonal A; Sideroxylonal A	CFN99601	145382-68-9	C₂₆H₂₈O₁₀ = 500.5	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.4647 mL	7.3233 mL	14.6466 mL	29.2933 mL	36.6166 mL
5 mM	0.2929 mL	1.4647 mL	2.9293 mL	5.8587 mL	7.3233 mL
10 mM	0.1465 mL	0.7323 mL	1.4647 mL	2.9293 mL	3.6617 mL
50 mM	0.0293 mL	0.1465 mL	0.2929 mL	0.5859 mL	0.7323 mL
100 mM	0.0146 mL	0.0732 mL	0.1465 mL	0.2929 mL	0.3662 mL