| Description: |
Supplementation of Genistin alone or with selenium provides antioxidant defense with high-potential chemopreventive activity against DMBA-induced mammary tumors more than selenium alone.Intravitreal injection of Genistin is safe and effective in reducing traumatic PVR in clinical treatment. |
| In vitro: |
| J Food Sci Technol. 2014 Oct;51(10):2857-61. | | Effect of ultrasound assisted extraction upon the Genistin and Daidzin contents of resultant soymilk.[Pubmed: 25328238] | The purpose of this study was to determine the effect of ultrasound treatment on the contents of daidzin, Genistin, and their respective aglycones, daidzein and genistein, in resultant soymilk.
METHODS AND RESULTS:
Soybean slurry was exposed to ultrasound treatment, filtered, and placed in an ultrasound cleaning bath set with different frequencies (35and 130 KHz), treatment temperatures (20 and 40 °C), and times (20, 40, and 60 min). Concentrations for these isoflavones were determined using reverse-phase high-performance liquid chromatography. Results indicated that both frequencies significantly (p < 0.05) increased isoflavone content (IC), glycosides, and aglycones in extracted soymilk. These results were attributed to induced cavitation, which increases the permeability of plant tissues. However, the frequency of 35 kHz caused a noticeably higher increase in IC than 130 kHz. Results also revealed significant increases in IC with increased sonication time (from 20 to 60 min) and with increased temperature (from 20 to 40 °C). |
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| In vivo: |
| Toxicol Ind Health. 2012 Sep;28(8):746-57. | | Prevention of rat breast cancer by genistin and selenium.[Pubmed: 22089659] | Breast cancer is the second leading cause of cancer death among women and the third most common cancer.
METHODS AND RESULTS:
In this study, we investigated the chemoprevention efficacy of each of soy Genistin, selenium or a combination of them against breast cancer. Seventy-five female rats were divided into five groups : control group (I); 7,12-dimethylbenz(a)anthracene (DMBA) group (II); DMBA treated with Genistin group (III); DMBA treated with selenium group (IV); and DMBA treated with Genistin combined with selenium group (V). The treatments were daily administered for 3 months. There were a significant decrease in body weight and serum total antioxidant, while a significant elevation in serum total sialic acid, carcinoembryonic antigen, prolactin, estradiol, nitric oxide, and malondialdhyde of DMBA injected rats compared with control group. Administration of Genistin and selenium was associated with decreasing levels of tumorigenicity, endocrine derangement, and oxidative stress. Formation of breast carcinoma in DMBA-induced rats and abnormal changes were ameliorated in the rats treated with Genistin/selenium or Genistin alone.
CONCLUSIONS:
Supplementation of Genistin alone or with selenium provided antioxidant defense with high-potential chemopreventive activity against DMBA-induced mammary tumors more than selenium alone. |
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