11-Hydroxy-12-methoxyabietatriene

	产品编号	CFN92286
	CAS编号	16755-54-7
	分子式 = 分子量	C₂₁H₃₂O₂ = 316.5
	产品纯度	>=98%
	物理属性	Cryst.
	化合物类型	Diterpenoids
	植物来源	The herbs of Salvia candidissima
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
11-Hydroxy-12-methoxyabietatriene	CFN92286	16755-54-7	1mg	QQ客服：2159513211
11-Hydroxy-12-methoxyabietatriene	CFN92286	16755-54-7	5mg	QQ客服：2159513211
11-Hydroxy-12-methoxyabietatriene	CFN92286	16755-54-7	10mg	QQ客服：2159513211
11-Hydroxy-12-methoxyabietatriene	CFN92286	16755-54-7	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

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Description:

11-Hydroxy-12-methoxyabietatriene is a natural product from Salvia candidissima.

In vitro:

J Agric Food Chem. 2005 Jun 29;53(13):5200-6.

Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity.[Pubmed: 15969497 ]

METHODS AND RESULTS:
The new diterpenes brussonol (1) and iguestol (6alpha,11-dihydroxy-12-methoxy-abieta-8,11,13-triene) (2) with an icetexane and a dehydroabietane skeleton, respectively, have been isolated from hairy root cultures of Salvia broussonetii. Other previously known diterpenes, 7-oxodehydroabietane, 11-Hydroxy-12-methoxyabietatriene, taxodione, inuroyleanol, ferruginol, deoxocarnosol 12-methyl ether, cryptojaponol, pisiferal, sugiol, isomanool, 14-deoxycoleon U, 6alpha-hydroxydemethylcryptojaponol, demethylsalvicanol, and demethylcryptojaponol, were also obtained from these roots. The insect antifeedant and toxic effects of several of these compounds were investigated against the insect pests Spodoptera littoralis and Leptinotarsa decemlineata. Additionally, their comparative cytotoxic effects were tested on insect Sf9 and mammalian CHO cells. Demethylsalvicanol (4) was a moderate antifeedant to L. decemlineata, whereas brussonol (1) was inactive. 14-Deoxycoleon U (15) was the strongest antifeedant, whereas demethylcryptojaponol (11) was toxic to this insect.
CONCLUSIONS:
None of these compounds had antifeedant or negative effects on S. littoralis ingestion or weight gains after oral administration. Demethylcryptojaponol (11) was cytotoxic to mammalian CHO and insect Sf9 cell lines, followed by the icetexane derivative brussonol (1), with moderate cytotoxicity in both cases. The remainder of the test compounds showed a strong selective cytotoxicty to insect Sf9 cells, with demethylsalvicanol (4) being the most active.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
12-O-甲基鼠尾草酸; 12-O-Methylcarnosic acid	CFN89377	62201-71-2	C₂₁H₃₀O₄ = 346.46	5mg	QQ客服：2056216494
11-Hydroxy-12-methoxyabietatriene; 11-Hydroxy-12-methoxyabietatriene	CFN92286	16755-54-7	C₂₁H₃₂O₂ = 316.5	5mg	QQ客服：3257982914
11-羟基柳杉酚; 11-Hydroxy-sugiol	CFN90366	88664-08-8	C₂₀H₂₈O₃ = 316.43	5mg	QQ客服：2159513211
丹参酚酮; Salvinolone	CFN92243	120278-22-0	C₂₀H₂₆O₃ = 314.4	5mg	QQ客服：3257982914
6-羟基丹参酚酮; 14-Deoxycoleon U	CFN97924	88664-09-9	C₂₀H₂₆O₄ = 330.4	5mg	QQ客服：2056216494
20-去氧鼠尾草酚; 20-Deoxocarnosol	CFN92175	94529-97-2	C₂₀H₂₈O₃ = 316.4	5mg	QQ客服：1457312923
2,11,12-Trihydroxy-7,20-epoxy-8,11,13-abietatriene; 2,11,12-Trihydroxy-7,20-epoxy-8,11,13-abietatriene	CFN95428	1608462-12-9	C₂₀H₂₈O₄ = 332.4	10mg	QQ客服：1457312923
6-Epidemethylesquirolin D; 6-Epidemethylesquirolin D	CFN99695	165074-00-0	C₂₀H₂₈O₅ = 348.4	5mg	QQ客服：1457312923
鼠尾草酚; Carnosol	CFN99956	5957-80-2	C₂₀H₂₆O₄ = 330.42	20mg	QQ客服：2159513211
异迷迭香酚; Isorosmanol	CFN93009	93780-80-4	C₂₀H₂₆O₅ = 346.42	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1596 mL	15.7978 mL	31.5956 mL	63.1912 mL	78.9889 mL
5 mM	0.6319 mL	3.1596 mL	6.3191 mL	12.6382 mL	15.7978 mL
10 mM	0.316 mL	1.5798 mL	3.1596 mL	6.3191 mL	7.8989 mL
50 mM	0.0632 mL	0.316 mL	0.6319 mL	1.2638 mL	1.5798 mL
100 mM	0.0316 mL	0.158 mL	0.316 mL	0.6319 mL	0.7899 mL