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    诃子宁

    Chebulanin

    诃子宁
    产品编号 CFN92294
    CAS编号 166833-80-3
    分子式 = 分子量 C27H24O19 = 652.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The fruits of Terminalia chebula
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    诃子宁 CFN92294 166833-80-3 1mg QQ客服:1457312923
    诃子宁 CFN92294 166833-80-3 5mg QQ客服:1457312923
    诃子宁 CFN92294 166833-80-3 10mg QQ客服:1457312923
    诃子宁 CFN92294 166833-80-3 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Melbourne (Australia)
  • Deutsches Krebsforschungszentrum (Germany)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Ateneo de Manila University (Philippines)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • University of Hawaii Cancer Center (USA)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Srinakharinwirot University (Thailand)
  • University of Amsterdam (Netherlands)
  • Shanghai Institute of Organic Chemistry (China)
  • Harvard University (USA)
  • Chang Gung University (Taiwan)
  • Chungnam National University (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Tumour Biol.2015, 36(9):7027-34
  • Int. Conference on Med. Sci. and Bio.2017, 17973
  • J Ethnopharmacol.2017, 198:205-213
  • Biorxiv2019, 10.1101
  • Biomed Pharmacother.2019, 116:108987
  • Cardiovasc Toxicol.2019, 19(4):297-305
  • Int J Mol Sci.2019, 20(9):E2244
  • J of the Korean Society of Cosmetics and Cosmetology2019, 225-231
  • Molecules.2019, 24(1):E159
  • Molecules.2019, 24(10):E1930
  • Process Biochemistry2019, 85:106-115
  • Process Biochemistry2019, 87:213-220
  • United States Patent Application2020, 20200038363
  • Dent Mater J.2020, 39(4):690-695
  • Pharmacognosy Journal.2020, 12(2), p232-235.
  • Phytomedicine.2020, 153440.
  • Molecules.2020, 25(15):3353.
  • Molecules.2020, 25(18),4089.
  • Horticulturae2020, 6(4),76.
  • Plants (Basel).2020, 9(11):1422.
  • Plants (Basel).2020, 9(11):1555.
  • Reprod Toxicol.2020, 96:1-10.
  • Nutraceutical Research . 2021, 19(1),p90-105.
  • ...
  • 生物活性
    Description: Chebulanin is a topoisomerase I inhibitor, it inhibits the calcineurin pathway in C. neoformans. Chebulanin exhibits potent antifungal activity against various human pathogenic fungi with minimum inhibitory concentrations ranging from 0.25 to over 64 μg/ml. Chebulanin shows strong radical scavenging activity, good potency to chelate Fe2⁺ and good inhibition ability of lipid peroxidation. Chebulanin is a strong therapeutic alternative for the treatment of rheumatism arthritis, it suppresses the expression of inflammatory mediators and prevents cartilage destruction and bone erosion in mice.Chebulanin has anti-cancer acrtivity, it has apparent capacities of inhibiting the survival of MCF-7 human cancer cell line.
    Targets: TNF-α | IL Receptor | MMP(e.g.TIMP) | COX | Antifection
    In vitro:
    Food Chemistry, 2011 , 126 (1) :277-282.
    Antioxidant and antiproliferative capacities of phenolics purified from Phyllanthus emblica L. fruit[Reference: WebLink]
    Phyllanthus emblica is a widely distributed tropical medicinal plant with good therapeutic properties.
    METHODS AND RESULTS:
    Gallic acid, ellagic acid, mucic acid 1,4-lactone 3-O-gallate, isocorilagin, Chebulanin, chebulagic acid and mallotusinin were isolated and purified from this plant. The antioxidant activities of these compounds were evaluated by in vitro models of scavenging superoxide anion radicals, DPPH radicals and ABTS radicals, chelating ability of ferrous ion and inhibition capability of Fe (II)-induced lipid peroxidation, respectively. The results revealed that all the tested phenolics showed strong radical scavenging activity, good potency to chelate Fe2+ and good inhibition ability of lipid peroxidation. Amongst mallotusinin and mucic acid 1,4-lactone 3-O-gallate were reported for the first time to have antioxidant activity. In addition, the in vitro antiproliferative activities of those phenolics against MCF-7 breast cancer cell lines were assessed.
    CONCLUSIONS:
    Although the growth inhibition values induced by different phenolics on MCF-7 cell line yielded different effects, all the tested phenolics had apparent capacities of inhibiting the survival of MCF-7 human cancer cell line.
    In vivo:
    PLoS One. 2015 Sep 24;10(9):e0139052.
    Anti-Arthritic Effect of Chebulanin on Collagen-Induced Arthritis in Mice.[Pubmed: 26402786 ]
    Rheumatoid arthritis is a chronic degenerative autoimmune disease characterized by persistent inflammation of synovial membranes, which leads to cartilage destruction and bone erosion. To date, there are no effective therapies to slow the progress of this degenerative condition.
    METHODS AND RESULTS:
    Here, we evaluate the anti-arthritic effect of Chebulanin, an abundant anti-inflammatory agent isolated from Terminalia chebula, in collagen induced arthritis in DBA/1 mice by intragastric administration. Arthritic severity was scored by performing histopathological evaluation of the joints and measuring the expression of inflammatory cytokines and relative enzymes by immunohistochemical staining. In parallel, bone destruction and erosion were confirmed by micro-CT. Our data revealed that Chebulanin significantly improved the severity of arthritis. Specifically, the histopathological characteristics of the tissues were improved and expression of TNF-α, IL-6, MMP-3 and COX-2 in the paws and joints of the treated mice decreased in a dose-dependent manner compared with control mice. Furthermore, micro-CT analysis revealed that Chebulanin induced a dose-dependent reduction in cartilage destruction and bone erosion.
    CONCLUSIONS:
    Taken together, our findings suggest that Chebulanin suppresses the expression of inflammatory mediators and prevents cartilage destruction and bone erosion in mice. Therefore, Chebulanin is a strong therapeutic alternative for the treatment of RA.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5326 mL 7.6628 mL 15.3257 mL 30.6513 mL 38.3142 mL
    5 mM 0.3065 mL 1.5326 mL 3.0651 mL 6.1303 mL 7.6628 mL
    10 mM 0.1533 mL 0.7663 mL 1.5326 mL 3.0651 mL 3.8314 mL
    50 mM 0.0307 mL 0.1533 mL 0.3065 mL 0.613 mL 0.7663 mL
    100 mM 0.0153 mL 0.0766 mL 0.1533 mL 0.3065 mL 0.3831 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    新诃黎勒鞣花酸甲酯; Methyl neochebulinate CFN95201 1236310-34-1 C42H36O28 = 988.7 5mg QQ客服:2932563308
    1,2,3,6-四-O-没食子酰-β-D-葡萄糖; 1,2,3,6-Tetragalloylglucose CFN00447 79886-50-3 C34H28O22 = 788.57 5mg QQ客服:3257982914
    1,3,6-三没食子酰葡萄糖; 1,3,6-Tri-O-galloylglucose CFN95043 18483-17-5 C27H24O18 = 636.5 10mg QQ客服:3257982914
    葡萄糖没食子鞣苷; beta-Glucogallin CFN70245 13405-60-2 C13H16O10 = 332.3 5mg QQ客服:1457312923
    1-O-没食子酰-6-O-肉桂酰葡萄糖; 1-O-galloyl-6-O-cinnamoylglucose CFN95053 115746-69-5 C22H22O11 = 462.4 5mg QQ客服:2159513211
    2-肉桂酰-1-没食子酰葡萄糖; 2-Cinnamoyl-1-galloylglucose CFN95098 56994-83-3 C22H22O11 = 462.4 5mg QQ客服:1413575084
    1,2,3,4,6-五没食子酰葡萄糖; 1,2,3,4,6-O-Pentagalloylglucose CFN90192 14937-32-7 C41H32O26 = 940.68 20mg QQ客服:2056216494
    单宁酸; Tannic acid CFN90501 1401-55-4 C76H52O46 = 1701.2 20mg QQ客服:1413575084
    柯里拉京; Corilagin CFN90176 23094-69-1 C27H22O18 = 634.45 20mg QQ客服:2056216494
    诃子宁; Chebulanin CFN92294 166833-80-3 C27H24O19 = 652.5 5mg QQ客服:3257982914

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