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  • Thonningianin A

    Thonningianin A

    Thonningianin A
    产品编号 CFN90633
    CAS编号 271579-11-4
    分子式 = 分子量 C42H34O21 = 874.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Chalcones
    植物来源 The herbs of Penthorum chinense Pursh
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Thonningianin A CFN90633 271579-11-4 10mg QQ客服:3257982914
    Thonningianin A CFN90633 271579-11-4 20mg QQ客服:3257982914
    Thonningianin A CFN90633 271579-11-4 50mg QQ客服:3257982914
    Thonningianin A CFN90633 271579-11-4 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Charles University in Prague (Czech Republic)
  • Universita' Degli Studi Di Cagliari (Italy)
  • University of Mysore (India)
  • Monash University (Australia)
  • St. Jude Children Research Hospital (USA)
  • Universidade da Beira Interior (Germany)
  • University of Zurich (Switzerland)
  • Colorado State University (USA)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • University of Pretoria (South Africa)
  • Universidad de La Salle (Mexico)
  • Medical University of South Carolina (USA)
  • Worcester Polytechnic Institute (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Toxins (Basel).2021, 13(9):593.
  • Foods.2021, 10(6):1378.
  • Food Chem.2019, 290:286-294
  • Nat Prod Commun.2017, 12(5):771-778
  • BMC Complement Altern Med.2019, 19(1):325
  • Univerzita Karlova2021, 20.500.11956.
  • Appl. Sci.2020, 10(4),1304
  • bioRxiv-Pharm.&Toxi.2022, 2022.481203.
  • Int J Mol Sci.2017, 19(1)
  • Neurotox Res.2020, 38(1):163-174.
  • Journal of Phytopathology2021, 169,Issue11-12.
  • Int J Mol Sci.2020, 21(9):3144.
  • Oxid Med Cell Longev.2022, 2022:9139338.
  • Korean J. Medicinal Crop Sci.2022, 30(2):117-123.
  • Asian Pac J Cancer Prev. 2020, 21(4):935-941.
  • Molecules2022, 27(12):3824.
  • Applied Biological Chemistry 2021, 64(75)
  • Biochem Biophys Res Commun.2018, 505(1):194-200
  • Sci Rep.2019, 9(1):18080
  • BMC Plant Biol.2018, 18(1):122
  • Phytomedicine.2015, 22(4):498-503
  • Agriculture.2022, 12(3), 342.
  • J Food Sci.2021, 86(9):3810-3823.
  • ...
  • 生物活性
    Description: Thonningianin A represents a new potent glutathione S-transferase in vitro inhibitor. Thonningianin A has anti-cancer and antioxidant properties, involves radical scavenging, anti-superoxide formation and metal chelation.
    Targets: Caspase | CDK | ERK | NF-kB | p38MAPK | NADPH-oxidase
    In vitro:
    Food Funct. 2015 Aug;6(8):2588-97.
    Effects of thonningianin A in natural foods on apoptosis and cell cycle arrest of HepG-2 human hepatocellular carcinoma cells.[Pubmed: 26119846]

    METHODS AND RESULTS:
    The anti-cancer activities of Thonningianin A on the HepG-2 human hepatocellular carcinoma cell line were evaluated by MTT assay, flow cytometry, quantitative real-time PCR and western blotting. Results showed that Thonningianin A effectively inhibited the proliferation of HepG-2 cells by inducing apoptosis, as evidenced by increase in the sub-G1 cell population, DNA fragmentation, and increase in the content of reactive oxygen species. Activation of caspase-9 and the subsequent activation of caspase-3 indicated that Thonningianin A-induced apoptosis is caspase-dependent. Thonningianin A also disrupted the mitochondrial membrane potential (Δψm) and down-regulated the Bcl-xL mRNA expression in HepG-2 cells. Thonningianin A induced cell cycle arrest by changing the cyclin D1 and CDK4 mRNA expression levels. Moreover, western blotting showed that Thonningianin A significantly down-regulated the NF-kappa-B cell survival pathway, along with up-regulation of the expression level of phosphorylated P38 and down-regulation of the expression level of phosphorylated ERK.
    CONCLUSIONS:
    The anti-cancer activity of Thonningianin A was confirmed by the characteristic patterns of DNA fragmentation and cell cycle arrest, suggesting that Th A is an effective antitumor ingredient in natural plant foods, and is worthy of further study.
    Biochem Pharmacol. 2002 May 1;63(9):1725-37.
    Antioxidant properties of Thonningianin A, isolated from the African medicinal herb, Thonningia sanguinea.[Pubmed: 12007576]
    The antioxidant properties of Thonningianin A (Th A), an ellagitannin, isolated from the methanolic extract of the African medicinal herb, Thonningia sanguinea were studied using the NADPH and Fe2+/ascorbate-induced lipid peroxidation (LPO), electron spin resonance spectrometer and the deoxyribose assay.
    METHODS AND RESULTS:
    Thonningianin A at 10 microM inhibited both the NADPH and Fe2+/ascorbate-induced LPO in rat liver microsomes by 60% without inhibitory effects on cytochrome P450 activity. Thonningianin A was similar to the synthetic antioxidant, tannic acid, as an inhibitor of both the NADPH and Fe2+/ascorbate-induced LPO but potent than gallic acid, vitamin C and vitamin E. While Thonningianin A poorly scavenged the hydroxyl radical generated by the Fenton reaction it dose-dependently scavenged 1,1-diphenyl-2-picrylhydrazyl, superoxide anion and peroxyl radicals with IC50 of 7.5, 10 and 30 microM, respectively. Furthermore, Thonningianin A showed inhibitory effects on the activity of xanthine oxidase with an IC50 of 30 microM. In the deoxyribose assay both T. sanguinea and its methanolic component Thonningianin A showed only site-specific (Fe3+ + H2O2) but not non-site-specific (Fe3+ + EDTA + H2O2) hydroxyl radical scavenging suggesting chelating ability for iron ions.
    CONCLUSIONS:
    Spectroscopic studies showed that Thonningianin A enhanced absorbance in the visible region in the presence of Fe2+ ions. These results indicate that the antioxidant properties of Thonningianin A involve radical scavenging, anti-superoxide formation and metal chelation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.1432 mL 5.7162 mL 11.4325 mL 22.865 mL 28.5812 mL
    5 mM 0.2286 mL 1.1432 mL 2.2865 mL 4.573 mL 5.7162 mL
    10 mM 0.1143 mL 0.5716 mL 1.1432 mL 2.2865 mL 2.8581 mL
    50 mM 0.0229 mL 0.1143 mL 0.2286 mL 0.4573 mL 0.5716 mL
    100 mM 0.0114 mL 0.0572 mL 0.1143 mL 0.2286 mL 0.2858 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    乔松苷;乔松素-7-O-β-D-葡萄糖苷; Pinocembroside CFN95444 75829-43-5 C21H22O9 = 418.4 20mg QQ客服:2932563308
    Thonningianin A; Thonningianin A CFN90633 271579-11-4 C42H34O21 = 874.7 20mg QQ客服:3257982914
    Pinocembrin 7-O-(4'',6''-hexahydroxydiphenoyl)-beta-D-glucose; Pinocembrin 7-O-(4'',6''-hexahydroxydiphenoyl)-beta-D-glucose CFN95462 1825287-22-6 C35H28O17 = 720.6 10mg QQ客服:215959384
    Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-β-D-glucose; Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-beta-D-glucose CFN90881 205370-59-8 C42H32O21 = 872.7 20mg QQ客服:1413575084
    2,6-Dihydroxyacetophenone-4-O-[4',6'-(S)-hexahydroxydiphenoyl]-beta-D-glucose; 2,6-Dihydroxyacetophenone-4-O-[4',6'-(S)-hexahydroxydiphenoyl]-beta-D-glucose CFN95470 1781226-44-5 C28H24O17 = 632.5 5mg QQ客服:3257982914
    老鹳草素; Geraniin CFN90256 60976-49-0 C41H28O27 = 952.64 20mg QQ客服:3257982914
    叶下珠鞣质C; Phyllanthusiin C CFN95260 142674-52-0 C40H30O26 = 926.7 5mg QQ客服:215959384
    诃子鞣酸; Chebulagic acid CFN92295 23094-71-5 C41H30O27 = 954.7 5mg QQ客服:1148253675
    诃子林鞣酸; Chebulinic acid CFN92296 18942-26-2 C41H32O27 = 956.7 20mg QQ客服:2932563308
    新诃黎勒鞣花酸甲酯; Methyl neochebulinate CFN95201 1236310-34-1 C42H36O28 = 988.7 5mg QQ客服:215959384

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