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  • 赤式-愈创木基 beta-O-4'-脱氢二芥子醇基醚

    erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether

    赤式-愈创木基 beta-O-4'-脱氢二芥子醇基醚
    产品编号 CFN96718
    CAS编号 613684-55-2
    分子式 = 分子量 C31H36O11 = 584.61
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The seed shell of Hevea brasiliensis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    赤式-愈创木基 beta-O-4'-脱氢二芥子醇基醚 CFN96718 613684-55-2 1mg QQ客服:1457312923
    赤式-愈创木基 beta-O-4'-脱氢二芥子醇基醚 CFN96718 613684-55-2 5mg QQ客服:1457312923
    赤式-愈创木基 beta-O-4'-脱氢二芥子醇基醚 CFN96718 613684-55-2 10mg QQ客服:1457312923
    赤式-愈创木基 beta-O-4'-脱氢二芥子醇基醚 CFN96718 613684-55-2 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Universitas Airlangga (Indonesia)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Universite de Lille1 (France)
  • Sri Ramachandra University (India)
  • Ateneo de Manila University (Philippines)
  • University of Wuerzburg (Germany)
  • Texas A&M University (USA)
  • Copenhagen University (Denmark)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Korea Institute of Oriental Medicine (Korea)
  • Kyung Hee University (Korea)
  • University of Vigo (Spain)
  • Universitas islam negeri Jakarta (Indonesia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Journal of Molecular Liquids2022, 364:120062.
  • Scientific World Journal.2014, 2014:654193
  • Phytomedicine.2022, 110:154597.
  • J Separation Science & Technology2016, 51:1579-1588
  • Food Structure2023, 36:100324.
  • ACS Omega.2021, 6(36):23460-23474.
  • Molecules.2023, 28(9):3685.
  • Plant Physiol Biochem.2023, 201:107795.
  • Oncol Rep.2021, 46(2):166.
  • Environ Toxicol.2023, 23929.
  • Phytother Res.2019, 33(4):1104-1113
  • European Journal of Integrative Medicine2018, 20:165-172
  • LWT2020, 126:109313
  • Kor. J. Herbol.2022, 37(5): 89-96.
  • TCI CO.2019, US20190151257A1
  • Antioxidants.2022, 11(4), 67.
  • Ind. J. Pharm. Edu. Res.2023; 57(3):1132-1139.
  • J. Traditional Thai Medical Res. 2022,8(1):1-14.
  • Inflammation.2015, 38(4):1502-16
  • Biocell2023, 47(8):1793-1802
  • Nat Commun.2023, 14(1):4540.
  • J Cell Mol Med.2023, jcmm.18071.
  • J. of Agricultural Science2015, 1916-9760
  • ...
  • 生物活性
    Description: erythro-Guaiacylglycerol-β-O-4'-dehydrodisinapyl ether shows inhibitory activity against human leukocyte elastase with the IC50 value of 171 umol·L-1.
    In vitro:
    Chinese Journal of New Drugs, 2012, 21(19):2311-2315.
    Chemical constituents of the seed shell of Hevea brasiliensis.[Reference: WebLink]
    To study the chemical constituents of the seed shell of Hevea brasiliensis.
    METHODS AND RESULTS:
    The compounds were isolated by chromatography on silica gel, LH-20, ODS-C18 and HPLC. Their structures were identified by physicochemical and spectral analysis. MTT assays in vitro were used to explore the inhibitory effect of these compounds on B16 cancer cells, and a high through-put screening method was used to explore the HLE inhibitors. Nine compounds were isolated and identified as vanillin(1), coniferaldehyde(2), erythro-guaiacylglycerol-β-coniferyl aldehyde ether(3), threo-guaiacylglycerol-β-coniferyl aldehyde ether(4), (-)-balanophonin(5), isoamericanol A (6), americanol A (7),erythro-Guaiacylglycerol-beta-O-4'-dehydrodisinapyl ether (8), and buddlenol A (9). Compound 9 showed anti-tumor activity against B16 cancer cells with IC50 value of 20.6 μmol·L-1. Compounds 5~9 showed inhibitory activity against human leukocyte elastase with IC50 values of 168, 45.5, 57.6, 171 and 115 μmol·L-1, respectively.
    CONCLUSIONS:
    All compounds were isolated from this plant for the first time. Compound 9 showed inhibitory activity on B16 cancer cells, and compounds 5~9 were reported as human leukocyte elastase inhibitors for the first time.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7105 mL 8.5527 mL 17.1054 mL 34.2108 mL 42.7636 mL
    5 mM 0.3421 mL 1.7105 mL 3.4211 mL 6.8422 mL 8.5527 mL
    10 mM 0.1711 mL 0.8553 mL 1.7105 mL 3.4211 mL 4.2764 mL
    50 mM 0.0342 mL 0.1711 mL 0.3421 mL 0.6842 mL 0.8553 mL
    100 mM 0.0171 mL 0.0855 mL 0.1711 mL 0.3421 mL 0.4276 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    丹参醇 C; Danshenol C CFN96391 910856-25-6 C21H20O4 = 336.4 5mg QQ客服:3257982914
    丹酚酸C; Salvianolic acid C CFN98553 115841-09-3 C26H20O10 = 492.44 20mg QQ客服:215959384
    白屈菜酸; Chelidonic acid CFN94111 99-32-1 C7H4O6 = 184.10 20mg QQ客服:2159513211
    Gaudichaudic acid; Gaudichaudic acid CFN92091 887923-46-8 C33H38O8 = 562.7 5mg QQ客服:1413575084

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