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  • α-托可醌

    alpha-Tocopherolquinone

    α-托可醌
    产品编号 CFN97235
    CAS编号 7559-04-8
    分子式 = 分子量 C29H50O3 = 446.7
    产品纯度 >=98%
    物理属性 Yellow oil
    化合物类型 Quinones
    植物来源 The herbs of Isodon adenantha.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    α-托可醌 CFN97235 7559-04-8 10mg QQ客服:2159513211
    α-托可醌 CFN97235 7559-04-8 20mg QQ客服:2159513211
    α-托可醌 CFN97235 7559-04-8 50mg QQ客服:2159513211
    α-托可醌 CFN97235 7559-04-8 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Parma (Italy)
  • Massachusetts General Hospital (USA)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Universidade da Beira Interior (Germany)
  • Medizinische Universit?t Wien (Austria)
  • Universitas islam negeri Jakarta (Indonesia)
  • CSIRO - Agriculture Flagship (Australia)
  • MTT Agrifood Research Finland (Finland)
  • Korea Institute of Oriental Medicine (Korea)
  • Julius Kühn-Institut (Germany)
  • Melbourne University (Australia)
  • Cornell University (USA)
  • Gyeongsang National University (Korea)
  • Kyushu University (Japan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Neurobiol.2022, 02873-9.
  • Food Chem.2019, 274:345-350
  • Food and Chemical Toxicology2020, 111221
  • Natural Product Communications2020, doi: 10.1177.
  • Phytomedicine.2021, 84:153501.
  • LWT2020, 124:109163
  • Biomol Ther (Seoul).2019, 10.4062
  • Ind. J. Pharm. Edu. Res.2023; 57(3):1132-1139.
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • Industrial Crops and Products2017, 95:286-295
  • Fitoterapia.2022, 105141.
  • Phytomedicine.2021, 93:153789.
  • J Nat Med.2020, 74(3):550-560.
  • Plant Physiol Biochem.2019, 144:355-364
  • Int J Mol Sci.2021, 22(21):11447.
  • GENENCELL2023, 25:4356740
  • Braz J Med Biol Res. 2016, 49(7)
  • J Sep Sci.2018, 41(9):1938-1946
  • FEMS Microbiol Lett.2017, 364(11)
  • Life (Basel).2021, 11(12):1399.
  • Plants (Basel).2020, 9(11):1422.
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • Univerzita Karlova2022, 228192.
  • ...
  • 生物活性
    Description: Alpha-Tocopherolquinone has antioxidant effect, can inhibit lipid peroxidation and reduce cell division in both the glioma cell clone and fetal brain cells; it inhibits β-amyloid aggregation and cytotoxicity, disaggregates preformed fibrils and decreases the production of reactive oxygen species, NO and inflammatory cytokines.
    Targets: ROS | NO | TNF-α | IL Receptor | Beta Amyloid
    In vivo:
    J Clin Pharmacol. 2012 Jan;52(1):65-77.
    Use of an adaptive study design in single ascending-dose pharmacokinetics of A0001 (α-tocopherylquinone) in healthy male subjects.[Pubmed: 21343342]
    A0001 (alpha-Tocopherolquinone) is a potent antioxidant currently in development for the treatment of symptoms associated with inherited mitochondrial disorders.
    METHODS AND RESULTS:
    alpha-Tocopherolquinone pharmacokinetics were studied in a single-blind, adaptive design study following a single daily oral dose of placebo (n = 2) or ascending doses of alpha-Tocopherolquinone (n = 8) at 0.25 and 0.5 g under a fasted state or a 0.5- to 6-g dose with a high-fat meal. alpha-Tocopherolquinone plasma concentration-time profiles were similar across doses, reaching peak concentration within 4 to 6 hours, with concentrations returning to baseline within 24 hours. however, the nonproportionality was offset by administering alpha-Tocopherolquinone in divided doses (0.735 g, 3 times per day). The potential for an alpha-Tocopherolquinone:vitamin E interaction was also explored, as vitamin E use is prevalent in this patient population, and suggested that a clinically significant pharmacokinetic interaction is not likely. alpha-Tocopherolquinone was well tolerated with no serious adverse events or dose-limiting toxicities.
    CONCLUSIONS:
    These findings suggest that alpha-Tocopherolquinone has a favorable pharmacokinetic profile when administered orally with food.
    Biochem Int. 1985 May;10(5):753-61.
    Inhibition of lipid peroxidation by alpha-tocopherolquinone and alpha-tocopherolhydroquinone.[Pubmed: 4015671]
    The antioxidant effect of alpha-Tocopherolquinone and alpha-tocopherolhydroquinone was studied in liposomes and rat liver submitochondrial particles.
    METHODS AND RESULTS:
    Both alpha-Tocopherolquinone and alpha-tocopherolhydroquinone inhibit lipid peroxidation induced by ascorbate/Fe2+ in liposomes and by cumene hydroperoxide in submitochondrial particles. Alpha-tocopherolhydroquinone is much more effective than alpha-Tocopherolquinone in inhibiting lipid peroxidation. Submitochondrial particles, depleted of ubiquinones and reincorporated with alpha-Tocopherolquinone, are protected from lipid peroxidation only in the presence of succinate. alpha-
    CONCLUSIONS:
    Tocopherolquinone cannot replace endogenous ubiquinones in the respiratory chain function, nevertheless it can be reduced by the mitochondrial respiratory chain substrates, presumably through the reduced ubiquinones.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2386 mL 11.1932 mL 22.3864 mL 44.7728 mL 55.966 mL
    5 mM 0.4477 mL 2.2386 mL 4.4773 mL 8.9546 mL 11.1932 mL
    10 mM 0.2239 mL 1.1193 mL 2.2386 mL 4.4773 mL 5.5966 mL
    50 mM 0.0448 mL 0.2239 mL 0.4477 mL 0.8955 mL 1.1193 mL
    100 mM 0.0224 mL 0.1119 mL 0.2239 mL 0.4477 mL 0.5597 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4-羟基红根草对醌; 4-Hydroxysapriparaquinone CFN97936 120278-25-3 C20H26O4 = 330.4 5mg QQ客服:3257982914
    Salvisyrianone; Salvisyrianone CFN97952 250691-57-7 C20H24O3 = 312.4 5mg QQ客服:2056216494
    樱草素; Primin CFN90588 15121-94-5 C12H16O3 = 208.26 10mg QQ客服:1413575084
    2,5-二羟基-3-壬烷基-1,4-苯醌; Homoembelin CFN91184 38363-99-4 C15H22O4 = 266.3 5mg QQ客服:1457312923
    恩贝灵; 恩贝酸; Embelin CFN90537 550-24-3 C17H26O4 = 294.38 20mg QQ客服:215959384
    酸藤子醌; Rapanone CFN91185 573-40-0 C19H30O4 = 322.4 10mg QQ客服:1413575084
    α-托可醌; alpha-Tocopherolquinone CFN97235 7559-04-8 C29H50O3 = 446.7 20mg QQ客服:2056216494
    辅酶Q10; Coenzyme Q10 CFN99165 303-98-0 C59H90O4 = 863.36 20mg QQ客服:1413575084
    维生素 K1; Vitamin K1 CFN90050 84-80-0 C31H46O2 = 450.7 20mg QQ客服:1413575084

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