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  • 盐酸育亨宾

    Yohimbine Hydrochloride

    盐酸育亨宾
    产品编号 CFN99511
    CAS编号 65-19-0
    分子式 = 分子量 C21H26N2O3 HCL = 390.91
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Alkaloids
    植物来源 The peels of Corynante Yohimbe.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    盐酸育亨宾 CFN99511 65-19-0 10mg QQ客服:2159513211
    盐酸育亨宾 CFN99511 65-19-0 20mg QQ客服:2159513211
    盐酸育亨宾 CFN99511 65-19-0 50mg QQ客服:2159513211
    盐酸育亨宾 CFN99511 65-19-0 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Periyar University (India)
  • Chungnam National University (Korea)
  • Complutense University of Madrid (Spain)
  • Sri Ramachandra University (India)
  • University of Toulouse (France)
  • Copenhagen University (Denmark)
  • Worcester Polytechnic Institute (USA)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Institute of Chinese Materia Medica (China)
  • Universitas islam negeri Jakarta (Indonesia)
  • University of Pretoria (South Africa)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • MTT Agrifood Research Finland (Finland)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Chin. Med.J.Res. Prac.2017, 31(4)
  • Phytother Res.2022, ptr.7573.
  • Pharmaceuticals.2022, 15(4), 402.
  • Research Square2023, 2883170.
  • APMIS.2019, 127(10):688-695
  • Pharmacol Rep.2020, 72(2):472-480.
  • Int J Mol Sci.2023, 24(18):14077.
  • J Cell Mol Med . 2023, jcmm.17954.
  • Analytical sci. & Tech2020, 33(5):224-231
  • Phytochem Anal.2016, 27(5):296-303
  • Biochem Pharmacol. 2020, 177:114014.
  • Sci Rep.2019, 9(1):18080
  • Molecules.2019, 24(11):E2102
  • Chem Biol Interact.2022, 368:110248.
  • Molecules.2021, 26(4):1084.
  • Antioxidants (Basel).2020, 9(6):544.
  • Cancers (Basel).2023, 15(1):293.
  • Adaptive Medicine 2020, 12(1): 4-10
  • J Biochem Mol Toxicol.2017, 31(9)
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Int Immunopharmacol.2021, 100:108073.
  • Metabolites2022, 12(6),507.
  • Int J Biol Macromol.2020, 161:1230-1239.
  • ...
  • 生物活性
    Description: Yohimbine hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.It is an antagonist to xylazine hydrochloride-ketamine hydrochloride immobilization of white-tailed deer. Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
    Targets: Adrenergic Receptor | Dopamine Receptor
    In vivo:
    Am. J.Vet. Res., 1986, 47(4):949-52.
    Effect of yohimbine hydrochloride on serum prolactin concentration in the rat: possible antagonist for fescue toxicosis.[Pubmed: 3963600]
    Yohimbine hydrochloride is an indole alkaloid which blocks alpha 2-adrenergic and dopamine receptors and stimulates serotonergic receptors. Yohimbine was selected for testing as a possible antagonist in fescue toxicosis.
    METHODS AND RESULTS:
    Reduced body weight gains in cattle with chronic fescue toxicosis may be due to ergot alkaloids produced by fungi which infect the fescue grass. Ergot alkaloids stimulate dopamine receptors, antagonize serotonin, and lower serum prolactin concentrations. It was hypothesized that yohimbine may reverse or counteract the effects of the toxic fescue. Investigation was made of the treatment effects of multiple doses of yohimbine given in rats by intraperitoneal and oral routes. Given intraperitoneally once a day for 8 days, yohimbine hydrochloride increased serum prolactin concentrations. When given orally in feed for 7 days, the drug decreased the serum prolactin concentration. The effects of yohimbine on prolactin concentrations were dependent on the dosages and routes of administration.
    CONCLUSIONS:
    The inability of yohimbine, when given orally, to increase serum prolactin levels decreased its potential usefulness for prolonged treatment of fescue toxicosis.
    Psychother Psychosom. 2012;81(1):29-37.
    Does yohimbine hydrochloride facilitate fear extinction in virtual reality treatment of fear of flying? A randomized placebo-controlled trial.[Pubmed: 22116378]
    Research suggests that yohimbine hydrochloride (YOH), a noradrenaline agonist, can facilitate fear extinction. It is thought that the mechanism of enhanced emotional memory is stimulated through elevated noradrenaline levels. This randomized placebo-controlled trial examined the potential exposure-enhancing effects of YOH in a clinical sample of participants meeting DSM-IV criteria for a specific phobia (fear of flying).
    METHODS AND RESULTS:
    Sixty-seven participants with fear of flying were randomized to 4 sessions of virtual reality exposure therapy (VRET) combined with YOH (10 mg), or 4 sessions of VRET combined with a placebo. Treatment consisted of 4 weekly 1-hour exposure sessions consisting of two 25-minute virtual flights. At pre- and post- treatment, fear of flying was assessed. The YOH or placebo capsules were administered 1 h prior to exposures. The manipulation of the noradrenaline activity was confirmed by salivary α-amylase (sAA) samples taken pre-, during and post-exposure. Forty-eight participants completed treatment. Manipulation of noradrenaline levels with YOH was successful, with significantly higher levels of sAA in the YOH group when entering exposure. Results showed that both groups improved significantly from pre- to post-treatment with respect to anxiety reduction. However, although the manipulation of noradrenaline activity was successful, there was no evidence that YOH enhanced outcome.
    CONCLUSIONS:
    Participants improved significantly on anxiety measures independently of drug condition, after 4 sessions of VRET. These data do not support the initial findings of exposure-enhancing effects of YOH in this dosage in clinical populations.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5581 mL 12.7907 mL 25.5813 mL 51.1627 mL 63.9533 mL
    5 mM 0.5116 mL 2.5581 mL 5.1163 mL 10.2325 mL 12.7907 mL
    10 mM 0.2558 mL 1.2791 mL 2.5581 mL 5.1163 mL 6.3953 mL
    50 mM 0.0512 mL 0.2558 mL 0.5116 mL 1.0233 mL 1.2791 mL
    100 mM 0.0256 mL 0.1279 mL 0.2558 mL 0.5116 mL 0.6395 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    别育享宾; Allo-Yohimbine CFN92577 522-94-1 C21H26N2O3 = 354.5 5mg QQ客服:215959384
    利血平酸甲酯; Methyl reserpate CFN92579 2901-66-8 C23H30N2O5 = 414.5 5mg QQ客服:1457312923
    利血那明; Reserpinine CFN92580 24815-24-5 C35H42N2O9 = 634.7 5mg QQ客服:3257982914
    利血平氮氧化物; Reserpin N-oxide CFN92583 474-48-6 C33H40N2O10 = 624.7 5mg QQ客服:2159513211
    18-β-羟基-3-表-α-育亨宾; 18-Beta-hydroxy-3-epi-alpha-yohimbine CFN92610 81703-06-2 C21H26N2O4 = 370.5 5mg QQ客服:3257982914
    利血平; Reserpine CFN98112 50-55-5 C33H40N2O9 = 608.69 20mg QQ客服:1457312923
    羧酯利血平; Syrosingopine CFN98542 84-36-6 C35H42N2O11 = 666.71 5mg QQ客服:2056216494
    异柯楠碱; Isorauhimbine CFN98762 483-09-0 C21H26N2O3 = 354.5 5mg QQ客服:2056216494
    β-育亨宾; beta-Yohimbine CFN98921 549-84-8 C21H26N2O3 = 354.5 5mg QQ客服:215959384
    α-育亨宾; alpha-Yohimbine CFN99400 131-03-3 C21H26N2O3 = 354.5 5mg QQ客服:215959384

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