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  • O,O-二甲基鹅掌楸树脂醇 B

    Yangambin

    O,O-二甲基鹅掌楸树脂醇 B
    产品编号 CFN96416
    CAS编号 13060-14-5
    分子式 = 分子量 C24H30O8 = 446.49
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The leaves of Ocotea duckei Vattimo.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    O,O-二甲基鹅掌楸树脂醇 B CFN96416 13060-14-5 1mg QQ客服:2056216494
    O,O-二甲基鹅掌楸树脂醇 B CFN96416 13060-14-5 5mg QQ客服:2056216494
    O,O-二甲基鹅掌楸树脂醇 B CFN96416 13060-14-5 10mg QQ客服:2056216494
    O,O-二甲基鹅掌楸树脂醇 B CFN96416 13060-14-5 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Padjajaran (Indonesia)
  • Nanjing University of Chinese Medicine (China)
  • University of Bonn (Germany)
  • University of Hawaii Cancer Center (USA)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Anna University (India)
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  • Celltrion Chemical Research Institute (Korea)
  • University of Medicine and Pharmacy (Romania)
  • Universidade Católica Portuguesa (Portugal)
  • National Chung Hsing University (Taiwan)
  • Medical University of South Carolina (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
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  • The Korea Journal of Herbology2016, 29-35
  • J Chromatogr A.2017, 1518:46-58
  • Molecules.2019, 24(16):E3003
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  • FEBS J.2022, 10.1111:febs.16676.
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  • ...
  • 生物活性
    Description: Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibition the Ca2+ influx through voltage-gated Ca2+ channels. Yangambin has central nervous system activity, it presents a depressant activity in the open field, forced swimming and pentobarbital sleeping time tests.
    Targets: PAFR | Calcium Channel
    In vivo:
    Phytomedicine. 1996 Jan;2(3):235-42.
    Antagonistic effect of yangambin on platelet-activating factor (PAF)-induced cardiovascular collapse.[Pubmed: 23194622]
    The cardiovascular protective effects of yangambin, a novel and specific naturally-occurring platelet activating factor (PAF) receptor antagonist, were investigated in the pentobarbital anesthetized and artificially ventilated rat.
    METHODS AND RESULTS:
    Yangambin (3-30 mg kg(-1)) as well as the reference PAF antagonist WEB 2086 (0.1-1.0 mg kg(-1)) prevented the circulatory collapse elicited by the intravenous administration of PAF (0.5 μg kg(-1)), in a dose-dependent manner. Yangambin did not interfere with the hypotensive effect of several endogenous vasoactive mediators such as acetylcholine, bradykinin, histamine and serotonin. Moreover, when adminstered as a post-treatment the antagonist showed the ability to reverse the cardiovascular effects induced by PAF (1.0 μg kg(-1)). The protective effect of yangambin showed to have a duration of action of more than 2 hours.
    CONCLUSIONS:
    It is concluded that yangambin is a selective antagonist of the cardiovascular effects of PAF and therefore constitutes a potential therapeutic agent in different shock states where abnormal PAF release is supposed to play an important role.
    Molecules. 2014 May 23;19(5):6863-76.
    Calcium influx inhibition is involved in the hypotensive and vasorelaxant effects induced by yangambin.[Pubmed: 24858272 ]
    The pharmacological effects on the cardiovascular system of yangambin, a lignan isolated from Ocotea duckei Vattimo (Lauraceae), were studied in rats using combined functional and biochemical approaches.
    METHODS AND RESULTS:
    In non-anaesthetized rats, yangambin (1, 5, 10, 20, 30 mg/kg, i.v.) induced hypotension (-3.5 ± 0.2; -7.1 ± 0.8; -8.9 ± 1.3; -14 ± 2.3, -25.5% ± 2.6%, respectively) accompanied by tachycardia (5.9 ± 0.5; 5.9 ± 1.6; 8.8 ± 1.4; 11.6, 18.8% ± 3.4%, respectively). In isolated rat atria, yangambin (0.1 µM-1 mM) had very slight negative inotropic (Emax = 35.6% ± 6.4%) and chronotropic effects (Emax = 10.2% ± 2.9%). In endothelium-intact rat mesenteric artery, yangambin (0.1 µM-1 mM) induced concentration-dependent relaxation (pD2 = 4.5 ± 0.06) of contractions induced by phenylephrine and this effect was not affected by removal of the endothelium. Interestingly, like nifedipine, the relaxant effect induced by yangambin was more potent on the contractile response induced by KCl 80 mM (pD2 = 4.8 ± 0.05) when compared to that induced by phenylephrine. Furthermore, yangambin inhibited CaCl2-induced contractions in a concentration-dependent manner. This lignan also induced relaxation (pD2 = 4.0 ± 0.04) of isolated arteries pre-contracted with S(-)-Bay K 8644. In fura-2/AM-loaded myocytes of rat mesenteric arteries, yangambin inhibited the Ca2+ signal evoked by KCl 60 mM.
    CONCLUSIONS:
    In conclusion, these results suggest that the hypotensive effect of yangambin is probably due to a peripheral vasodilatation that involves, at least, the inhibition the Ca2+ influx through voltage-gated Ca2+ channels.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2397 mL 11.1985 mL 22.3969 mL 44.7938 mL 55.9923 mL
    5 mM 0.4479 mL 2.2397 mL 4.4794 mL 8.9588 mL 11.1985 mL
    10 mM 0.224 mL 1.1198 mL 2.2397 mL 4.4794 mL 5.5992 mL
    50 mM 0.0448 mL 0.224 mL 0.4479 mL 0.8959 mL 1.1198 mL
    100 mM 0.0224 mL 0.112 mL 0.224 mL 0.4479 mL 0.5599 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    松脂醇-4-O-beta-D-吡喃葡萄糖苷; Pinoresinol 4-O-beta-D-glucopyranoside CFN97180 69251-96-3 C26H32O11 = 520.5 20mg QQ客服:215959384
    (+)-表松脂素-4′-O-β-D-葡萄糖苷; Epipinoresinol-4-O-beta-D-glucoside CFN80044 24404-49-7 C26H32O11 = 520.52 5mg QQ客服:2056216494
    松脂醇二葡萄糖苷; Pinoresinol diglucoside CFN99994 63902-38-5 C32H42O16 = 682.67 20mg QQ客服:215959384
    8-羟基松脂醇-4'-O-beta-D-吡喃葡萄糖苷; 8-Hydroxypinoresinol-4'-O-beta-D-glucopyranoside CFN95356 102582-69-4 C26H32O12 = 536.5 5mg QQ客服:2159513211
    8-羟基松脂醇二葡萄糖苷; 8-Hydroxypinoresinol diglucoside CFN95083 112747-99-6 C32H42O17 = 698.7 5mg QQ客服:1413575084
    8-羟基松脂醇; 8-Hydroxypinoresinol CFN92432 81426-17-7 C20H22O7 = 374.4 5mg QQ客服:2056216494
    8-乙酰氧基松脂醇; 8-Acetoxypinoresinol CFN00449 81426-14-4 C22H24O8 = 416.43 5mg QQ客服:1413575084
    波棱酮; Herpetone CFN90676 951677-22-8 C29H30O9 = 522.54 5mg QQ客服:2159513211
    O,O-二甲基鹅掌楸树脂醇 B; Yangambin CFN96416 13060-14-5 C24H30O8 = 446.49 10mg QQ客服:1457312923
    O,O-二甲基鹅掌楸树脂醇 A; Epiyangambin CFN96723 24192-64-1 C24H30O8 = 446.49 5mg QQ客服:1413575084

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