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  • 乙酸雷公藤内酯A

    Wilforlide A acetate

    乙酸雷公藤内酯A
    产品编号 CFN97336
    CAS编号 84104-80-3
    分子式 = 分子量 C32H48O4 = 496.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Tripterygium wilfordii Hook.f.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    乙酸雷公藤内酯A CFN97336 84104-80-3 1mg QQ客服:3257982914
    乙酸雷公藤内酯A CFN97336 84104-80-3 5mg QQ客服:3257982914
    乙酸雷公藤内酯A CFN97336 84104-80-3 10mg QQ客服:3257982914
    乙酸雷公藤内酯A CFN97336 84104-80-3 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J. Pharm. Res. Int.2022, 34(58): pp.1-14.
  • Nutrients.2019, 12(1)
  • J Agric Food Chem.2020, 68(51):15164-15175
  • Toxicol Appl Pharmacol.2022, 434:115815.
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  • Front Microbiol.2023, 14:1232039.
  • Applied Biological Chemistry2022, 65(85).
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • Molecules.2019, 24(11):E2102
  • Korean J of Medicinal Crop Science2018, 220-226
  • Planta Med.2019, 85(4):347-355
  • Anticancer Res.2022, 42(9):4403-4410.
  • Universitat Stuttgart2022, opus-12200.
  • Molecules2022, 27(9):2613.
  • Molecules.2019, 24(24),4583
  • Data Science for Genomics2023, 107-128.
  • Cell Death Differ.2021, 1-8.
  • Drug Test Anal.2018, 10(10):1579-1589
  • J Mol Recognit.2020, 33(2):e2819
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • Drug Dev Res.2020, doi: 10.1002
  • Molecules2022, 27(3),1140.
  • Pharmaceutics.2022, 14(3):564.
  • ...
  • 生物活性
    Description: Wilforlide A (T1) serves as a quality control standard of Tripterygium Glycosides that be listed in Drug Standard of Ministry of Public Health of the People's Republic of China. T1 has anti-inflammatory effects.
    In vitro:
    Fitoterapia, 2010, 81(8):1109-1112.
    Comparative study on the anti-inflammatory and immune suppressive effect of Wilforlide A.[Reference: WebLink]
    Tripterygium Glycosides (TG) is effective in the treatment of patients with a variety of inflammatory and autoimmune diseases, especially rheumatoid arthritis (RA) in clinical. Wilforlide A (T1) serves as a quality control standard of TG that be listed in Drug Standard of Ministry of Public Health of the People's Republic of China. The pharmacologic actions of T1 remain to be unidentified.
    METHODS AND RESULTS:
    In this paper, we studied the anti-inflammatory and immune suppressive effect of T1, and compared it with Triptolide (TP), which believed to be the major active component of TG. Carrageenan-induced rat pedal swelling, tampon-induced rat granulation, and mice ear inhibition rate of swelling trail results show that high-dose T1 has obvious anti-inflammatory effect. Colorimetric detection contents of hemolysin, carbon elimination from plasma of mice, mice delayed hypersensitivity immune, and organ index were measured.
    CONCLUSIONS:
    The results show that T1 has no significant immune suppressive activity, and there has a significant difference with TP and TG. Therefore, we think the content of TP also should be controlled as a supplement standard in order to ensure safe and effective medication.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0133 mL 10.0664 mL 20.1329 mL 40.2658 mL 50.3322 mL
    5 mM 0.4027 mL 2.0133 mL 4.0266 mL 8.0532 mL 10.0664 mL
    10 mM 0.2013 mL 1.0066 mL 2.0133 mL 4.0266 mL 5.0332 mL
    50 mM 0.0403 mL 0.2013 mL 0.4027 mL 0.8053 mL 1.0066 mL
    100 mM 0.0201 mL 0.1007 mL 0.2013 mL 0.4027 mL 0.5033 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    22-羟基-3-氧代齐墩果-12-烯-29-酸; 22-Hydroxy-3-oxoolean-12-en-29-oic acid CFN99487 144629-84-5 C30H46O4 = 470.7 5mg QQ客服:2056216494
    3,22-二羟基齐墩果-12-烯-29-酸; 3,22-Dihydroxyolean-12-en-29-oic acid CFN97288 808769-54-2 C30H48O4 = 472.7 5mg QQ客服:1413575084
    Triptocallic acid D; Triptocallic acid D CFN98018 201534-09-0 C30H48O4 = 472.7 5mg QQ客服:2056216494
    雷公藤三萜酸A; Triptotriterpenic acid A CFN96474 84108-17-8 C30H48O4 = 472.70 5mg QQ客服:3257982914
    雷公藤内酯甲; 雷公藤内酯A; Wilforlide A CFN97335 84104-71-2 C30H46O3 = 454.7 20mg QQ客服:2056216494
    乙酸雷公藤内酯A; Wilforlide A acetate CFN97336 84104-80-3 C32H48O4 = 496.7 5mg QQ客服:1457312923
    美登木酸 ; Polpunonic acid CFN96834 33600-93-0 C30H48O3 = 456.71 5mg QQ客服:1413575084
    大子五层龙酸; Salaspermic acid CFN96837 71247-78-4 C30H48O4 = 472.71 5mg QQ客服:2056216494
    海棠果醛; Canophyllal CFN89150 14440-40-5 C30H48O2 = 440.71 5mg QQ客服:1457312923
    泻根醇酸; Bryonolic acid CFN98260 24480-45-3 C30H48O3 = 456.7 5mg QQ客服:215959384

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