韧革菌素B

Vibralactone B

	产品编号	CFN96455
	CAS编号	1093230-95-5
	分子式 = 分子量	C₁₂H₁₆O₄ = 224.26
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Sesquiterpenoids
	植物来源	From the cultures of the Basidiomycete Boreostereum vibrans.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
韧革菌素B	CFN96455	1093230-95-5	1mg	QQ客服：2056216494
韧革菌素B	CFN96455	1093230-95-5	5mg	QQ客服：2056216494
韧革菌素B	CFN96455	1093230-95-5	10mg	QQ客服：2056216494
韧革菌素B	CFN96455	1093230-95-5	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Chinese University of Hong Kong (China)

Universite de Lille1 (France)

The Vancouver Prostate Centre (VPC) (Canada)

University of Toulouse (France)

National Hellenic Research Foundation (Greece)

Pennsylvania State University (USA)

Aveiro University (Portugal)

University of Maryland School of Medicine (USA)

University of Melbourne (Australia)

Universidade de Franca (Brazil)

University of Liège (Belgium)

Shanghai Institute of Organic Chemistry (China)

Warszawski Uniwersytet Medyczny (Poland)

Sapienza University of Rome (Italy)

More...

Description:

Vibralactone B shows antibacterial activity, it can inhibit significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 ug/mL, respectively.

Targets:

Antifection

In vitro:

Food Chem Toxicol. 2017 May 18. pii: S0278-6915(17)30264-8.

Antifungal activities of secondary metabolites isolated from liquid fermentations of Stereum hirsutum (Sh134-11) against Botrytis cinerea (grey mould agent).[Pubmed: 28528973]

METHODS AND RESULTS:
Extracts obtained from liquid mycelial fermentations of the Chilean fungus Stereum hirsutum (Sh134-11) showed antifungal activity against Botrytis cinerea. Two types of extracts were obtained: EtOAc-extract (liquid phase) and MeOH-extract (mycelial phase). Plate diffusion assay showed that EtOAc-extracts were more active than MeOH-extracts. A large-scale fermentation of Sh134-11 and chromatographic methods allowed to isolated four compounds: MS-3, Vibralactone, Vibralactone B and Sterenin D. Only Sterenin D showed antifungal activity against B. cinerea in the tests performed. Effects on the mycelial growth of B. cinerea showed that Sterenin D showed inhibition at 1000-2000 μg/mL reaching 67% and 76% respectively. Sterenin D was more effective to control the sporogenesis, inhibiting in 96% the sporulation at 500 μg/mL. Assays showed that Sterenin D exhibited a minimal fungicidal concentration (MFC) of 50 μg/mL and minimal inhibitory concentration (MIC) at 20 μg/mL.
CONCLUSIONS:
Our study indicated that submerged fermentations of Chilean S. hirsutum (Sh134-11) produced extracts with antifungal activity and Sterenin D is responsible for this activity, which could be used as possible biofungicides alternative to synthetic fungicides.

Z Naturforsch C. 2015;70(3-4):97-102.

Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale.[Pubmed: 26020559 ]

METHODS AND RESULTS:
Liquid fermentations of the fungus Stereum rameale (N° 2511) yielded extracts with antibacterial activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration.
CONCLUSIONS:
Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 μg/mL), Bacillus subtilis (10 μg/mL) and Staphylococcus aureus (100 μg/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 μg/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 μg/mL, respectively.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
甜没药-3,10-二烯-2-酮; Bisabola-3,10-dien-2-one	CFN89224	61432-71-1	C₁₅H₂₄O = 220.35	5mg	QQ客服：215959384
1-羟基甜没药-2,10-二烯-4-酮; 1-Hydroxybisabola-2,10-dien-4-one	CFN96995	1213251-45-6	C₁₅H₂₄O₂ = 236.35	5mg	QQ客服：1413575084
4-(6-Methyl-4-oxohept-5-en-2-yl)cyclohex-2-en-1-one; 4-(6-Methyl-4-oxohept-5-en-2-yl)cyclohex-2-en-1-one	CFN89244	170380-68-4	C₁₄H₂₀O₂ = 220.31	5mg	QQ客服：3257982914
9-氧代-2,7-甜没药二烯-15-酸; 9-Oxo-2,7-bisaboladien-15-oic acid	CFN97512	93888-59-6	C₁₅H₂₂O₃ = 250.3	5mg	QQ客服：2159513211
4-羟基-4-甲基-2-((1R)-1-异丙基-4-氧代戊基)-2-环己烯-1-酮; 4-Hydroxy-1,10-secocadin-5-ene-1,10-dione	CFN96371	226904-40-1	C₁₅H₂₄O₃ = 252.4	5mg	QQ客服：1457312923
没药当归烯酮; Bisabolangelone	CFN91876	30557-81-4	C₁₅H₂₀O₃ = 248.32	10mg	QQ客服：1457312923
3,4-Seco-3-oxobisabol-10-ene-4,1-olide; 3,4-Seco-3-oxobisabol-10-ene-4,1-olide	CFN89267	1564265-85-5	C₁₅H₂₄O₃ = 252.35	5mg	QQ客服：2159513211
梓木内酯; Catalpalactone	CFN99670	1585-68-8	C₁₅H₁₄O₄ = 258.3	5mg	QQ客服：2056216494
梣酮; Fraxinellone	CFN99782	28808-62-0	C₁₄H₁₆O₃ = 232.28	20mg	QQ客服：2056216494
9beta-羟基梣酮; Dasycarpol	CFN96832	202343-57-5	C₁₄H₁₆O₄ = 248.27	5mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.4591 mL	22.2955 mL	44.5911 mL	89.1822 mL	111.4777 mL
5 mM	0.8918 mL	4.4591 mL	8.9182 mL	17.8364 mL	22.2955 mL
10 mM	0.4459 mL	2.2296 mL	4.4591 mL	8.9182 mL	11.1478 mL
50 mM	0.0892 mL	0.4459 mL	0.8918 mL	1.7836 mL	2.2296 mL
100 mM	0.0446 mL	0.223 mL	0.4459 mL	0.8918 mL	1.1148 mL

韧革菌素B

Vibralactone B

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