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  • 王不留行黄酮苷

    Vaccarin

    王不留行黄酮苷
    产品编号 CFN90131
    CAS编号 53452-16-7
    分子式 = 分子量 C32H38O19 = 726.64
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The seeds of Vaccaria segetalis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    王不留行黄酮苷 CFN90131 53452-16-7 10mg QQ客服:215959384
    王不留行黄酮苷 CFN90131 53452-16-7 20mg QQ客服:215959384
    王不留行黄酮苷 CFN90131 53452-16-7 50mg QQ客服:215959384
    王不留行黄酮苷 CFN90131 53452-16-7 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Queensland (Australia)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Universidade Católica Portuguesa (Portugal)
  • Agricultural Research Organization (ARO) (Israel)
  • Pennsylvania State University (USA)
  • Chinese University of Hong Kong (China)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Ateneo de Manila University (Philippines)
  • Universidad de Buenos Aires (Argentina)
  • University of Mysore (India)
  • University of Limpopo (South Africa)
  • Chulalongkorn University (Thailand)
  • University of Lodz (Poland)
  • Institute of Chinese Materia Medica (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Agriculture2022, 12(12), 2173.
  • J Chromatogr Sci.2020, 58(6):485-493.
  • Molecular & Cellular Toxicology2017, 13(3):271-278
  • Molecules.2022, 27(22):7887.
  • Int J Mol Sci.2021, 22(8):4211.
  • J Mol Med (Berl).2018, 96(7):661-672
  • Planta Med.2022, 88(9-10):794-804.
  • Neurochem Res.2021, s11064-021-03449-0
  • Korean J. Food Preserv. 2021, 28(6):846-856.
  • J of App. Res. on Med&Aromatic Plants2020, 100291.
  • Int J Mol Sci.2021, 22(21):11836.
  • Nanjing University of Chinese Medicine2022, 345930.
  • Vet World.2023, 16(3):618-630.
  • J Ethnopharmacol.2019, 228:132-141
  • Medicinal Chemistry Research 2021, 30:1117-1124.
  • Int J Biol Macromol.2020, 161:1230-1239.
  • bioRxiv-Pharm.&Toxi.2022, 2022.481203.
  • Food Chem.2020, 332:127412
  • Int J Oncol.2016, 49(4):1497-504
  • Pharmacological Reports2020, 1-9
  • Antioxidants (Basel).2022, 11(12):2496.
  • Braz J Biol.2023, 82:e266573.
  • Legume Science2021, 3(4): e101.
  • ...
  • 生物活性
    Description: Vaccarin exhibits extensive biological activities including vascular endothelial cell protective effects, it can significantly promote neovascularization by enhancing protein expression of p-Akt , p‑Erk, and CD31, and selectively protect vascular endothelium from dysfunction induced by H2O2.
    Targets: Akt | ERK | Caspase
    In vitro:
    Mol Med Rep. 2015 Jul;12(1):1131-6.
    Vaccarin promotes endothelial cell proliferation in association with neovascularization in vitro and in vivo.[Pubmed: 25815517]
    Angiogenesis is a major pathological component of several diseases, including traumatic vascular disease and coronary heart disease. The purpose of the present study was to determine the effects of Vaccarin on endothelial cell migration and neovascularization, which are important and necessary components of wound healing.
    METHODS AND RESULTS:
    The present study investigated and confirmed neovascularization induced by Vaccarin in vitro and in vivo. In vitro, the effects of Vaccarin (1.08 and 2.15 µM) on proliferation, migration and tube formation of human microvascular endothelial cells (HMEC)-1 were evaluated via sulforhodamine B assay and migration and tube formation assay, respectively. Furthermore, a mouse Matrigel plus model was used to detect capillary-like tube structures in vivo. Immunohistochemistry was used to detect the protein expression of cluster of differentiation 31 (CD31), p-AKT and p-extracellular-signal-regulated kinases (Erk). Vaccarin significantly promoted HMEC-1 proliferation and migration and tube formation of HMEC-1 at a dose of 2.15 µM. In vivo, Vaccarin delivered by daily oral administration significantly improved epidermal growth factor-induced angiogenesis in an intradermal inoculation mouse model.
    CONCLUSIONS:
    The mouse Matrigel model study also revealed that Vaccarin significantly promoted neovascularization via detection of CD31 levels and enhanced protein expression of p-Akt and p‑Erk. In addition, Vaccarin also promoted expression of CD31.
    Int J Mol Med. 2015 Jan;35(1):135-42.
    Vaccarin attenuates the human EA.hy926 endothelial cell oxidative stress injury through inhibition of Notch signaling.[Pubmed: 25352009]
    Endothelial cell injury is an essential component of atherosclerosis and hypertension. Atherosclerosis and other macrovascular diseases are the most common complications of diabetes. Vaccarin is a major flavonoid glycoside in Vaccariae semen, and is expected to be useful in the treatment of vascular diseases. The aim of the present study was to evaluate the possible effects of Vaccarin in human umbilical vein endothelial cells (EA.hy926) induced by hydrogen peroxide (H2O2) and its underlying mechanism in the prevention and treatment of H2O2 injury.
    METHODS AND RESULTS:
    In this study, the EA.hy926 cells were exposed to 250, 500 and 1000 µM H2O2 for 2 and 4 h in the absence or presence of Vaccarin, and the cell injury induced by H2O2 was examined via SRB. Cell migratory ability, lactate dehydrogenase (LDH) leakage, malondialdehyde (MDA) levels and decreasing superoxide dismutase (SOD) activity were evaluated by the wound healing assay and corresponding assay kits. Cell apoptosis was detected by flow cytometry with Annexin V-fluorescein isothiocyanate/propidium iodide Apoptosis Detection kit and Hoechst staining. Furthermore, western blot detected the protein expressions of Notch1, Hes1 and caspase-3. Following treatment with H2O2, it was found that H2O2 stimulated cell injury in a dose-dependent manner, including reducing cell viability and cell migratory ability, increasing LDH leakage and MDA levels, and decreasing SOD activity. H2O2 further accelerated cell apoptosis via activation of Notch1 and the downstream molecule Hes1. Preincubation with Vaccarin was found to protect EA.hy926 cells from H2O2-induced cell oxidative stress injury, which promoted cell viability and cell migratory ability, inhibited the level of LDH and MDA, but enhanced the activity of SOD. In particular, in addition to downregulation Notch signaling, Vaccarin treatments also downregulated caspase-3, a cell apoptotic pathway-related protein.
    CONCLUSIONS:
    These findings indicated that Vaccarin may be able to selectively protect vascular endothelium from dysfunction induced by H2O2.
    In vivo:
    Eur J Pharmacol . 2019 May 15;851:13-24.
    Vaccarin ameliorates insulin resistance and steatosis by activating the AMPK signaling pathway[Pubmed: 30779918]
    Abstract Destructive glucose and lipid metabolism in the liver is a crucial characteristic of type 2 diabetes mellitus (T2DM), eventually leading to insulin resistance and subsequent hyperglycemia and hyperlipidemia. Vaccarin is an active flavonoid glycoside associated with various biological functions, but its effects on glucose and lipid metabolic disorder in T2DM are still unclear. In this study, glucosamine (GlcN) and free fatty acids (FFAs, oleate/palmitate, 2:1 ratio) were applied to mimic insulin resistance and lipid deposition in HepG2 cells, respectively. Type 2 diabetic mice were induced using a high-fat diet (HFD) together with streptozotocin (STZ). GlcN stimulation was found to upregulate glucose production and gluconeogenesis but downregulate glycogen synthesis and phosphorylation of adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) in HepG2 cells, abnormal changes that were reversed by vaccarin. Furthermore, lipid accumulation was enhanced, but AMPK was inactivated in FFAs-exposed HepG2 cells, issues that were rectified by vaccarin treatment. These ameliorative effects of vaccarin on insulin resistance and steatosis were eliminated by AMPK inhibitor Compound C. In type 2 diabetic mice, chronic vaccarin administration decreased fasting blood glucose and lipid levels in both serum and the liver, and improved insulin sensitivity and steatosis in the liver. Taken together, these results suggest that vaccarin attenuates insulin resistance and steatosis by activating the AMPK signaling pathway. Keywords: AMPK; Insulin resistance; Steatosis; T2DM; vaccarin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3762 mL 6.881 mL 13.762 mL 27.5239 mL 34.4049 mL
    5 mM 0.2752 mL 1.3762 mL 2.7524 mL 5.5048 mL 6.881 mL
    10 mM 0.1376 mL 0.6881 mL 1.3762 mL 2.7524 mL 3.4405 mL
    50 mM 0.0275 mL 0.1376 mL 0.2752 mL 0.5505 mL 0.6881 mL
    100 mM 0.0138 mL 0.0688 mL 0.1376 mL 0.2752 mL 0.344 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    斯皮诺素; Spinosin CFN99600 72063-39-9 C28H32O15 = 608.55 20mg QQ客服:2056216494
    6'''-阿魏酰斯皮诺素; 6'''-Feruloylspinosin CFN90665 77690-92-7 C38H40O18 = 784.71 20mg QQ客服:2159513211
    黑豆黄素; Bayin CFN95539 3681-96-7 C21H20O9 = 416.4 5mg QQ客服:215959384
    牡荆素; Vitexin CFN98601 3681-93-4 C21H20O10 = 432.4 20mg QQ客服:1457312923
    牡荆素精铵酸盐; Vitexin argininate CFN93575 N/A C27H34N4O12 = 606.6 5mg QQ客服:215959384
    牡荆素7-O-葡萄糖苷; Vitexin 7-glucoside CFN70343 35109-95-6 C27H30O15 = 594.5 5mg QQ客服:1413575084
    2''-O-p-香豆酰基牡荆素; Vitexin 2''-O-p-coumarate CFN90654 59282-55-2 C30H26O12 = 578.5 5mg QQ客服:2159513211
    4-甲氧基牡荆素; 4'-O-Methylvitexin CFN90500 2326-34-3 C22H22O10 = 446.12 5mg QQ客服:1413575084
    Margaritene; Margaritene CFN95303 64271-10-9 C28H32O14 = 592.6 10mg QQ客服:1457312923
    砂生槐黄酮 A; Sophoraflavone A CFN95510 105594-08-9 C27H30O13 = 562.5 10mg QQ客服:215959384

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