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  • 钩藤酸E

    Uncarinic acid E

    钩藤酸E
    产品编号 CFN96468
    CAS编号 277751-61-8
    分子式 = 分子量 C39H54O6 = 618.84
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Uncaria rhynchophylla
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    钩藤酸E CFN96468 277751-61-8 1mg QQ客服:1457312923
    钩藤酸E CFN96468 277751-61-8 5mg QQ客服:1457312923
    钩藤酸E CFN96468 277751-61-8 10mg QQ客服:1457312923
    钩藤酸E CFN96468 277751-61-8 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Anna University (India)
  • University of Oslo (Norway)
  • Florida A&M University (USA)
  • Indian Institute of Science (India)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • University of Padjajaran (Indonesia)
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  • University of Limpopo (South Africa)
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  • Copenhagen University (Denmark)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2018, 18(1):303
  • J Pharm Biomed Anal.2016, 129:50-59
  • Mol Med Rep.2014, 9(5):1653-9
  • Food and Chemical Toxicology2020, 111221
  • Viruses.2021, 13(11):2118.
  • J Korean Soc Food Sci Nutr2023, 52(11):1101-1110
  • Acta Biochim Pol.2015, 62(2):253-8
  • FEBS J.2022, 10.1111:febs.16676.
  • Molecules2021, 26(1),230
  • Analytical Letters 2021, 54(4).
  • Plant Direct.2021, 5(12):e372.
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • Cell.2018, 172(1-2):249-261
  • J Ethnopharmacol.2019, 228:132-141
  • Environ Toxicol.2019, 34(12):1354-1362
  • Chem Res Toxicol. 2022, acs.chemrestox.2c00049.
  • Universitat Stuttgart2022, opus-12200.
  • LWT2021, 138:110397.
  • J of L. Chroma.&Related Tech2017, 252-258
  • Arch Pharm Res.2015, 38(6):1080-9
  • Analytical Letters.2020, doi 10.1008
  • J Ethnopharmacol.2024, 318:116863.
  • Int Immunopharmacol.2020, 90:107268.
  • ...
  • 生物活性
    Description: Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resulting in cytochrome c release from the mitochondria. A mixture of uncarinic acid E and 27-O-p-(E)-coumaroyloxyursolic acid exhibits antiplasmodial activity, with the IC50 value of 2.9 microg/ml.
    Targets: Bcl-2/Bax | Caspase | p53 | MEK | PI3K | Antifection
    In vitro:
    J Nat Prod. 2000 Jun;63(6):753-6.
    Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla.[Pubmed: 10869194]
    Investigation of the hooks of Uncaria rhynchophylla resulted in isolation of six phospholipase Cgamma1 (PLCgamma1) inhibitors (1-6).
    METHODS AND RESULTS:
    The structures of these compounds were elucidated as pentacyclic triterpene esters by spectroscopic and chemical analysis. Three of them, namely uncarinic acid C (1), uncarinic acid D (2), and Uncarinic acid E (3), are newly reported as natural products.
    CONCLUSIONS:
    All the compounds showed dose-dependent inhibitory activities against PLCgamma1 in vitro with IC(50) values of 9.5-44.6 microM and inhibited the proliferation of human cancer cells with IC(50) values of 0.5-6.5 microg/mL.
    J Ethnopharmacol. 2003 Oct;88(2-3):275-7.
    Antiplasmodial triterpenes from twigs of Gardenia saxatilis.[Pubmed: 12963155]

    METHODS AND RESULTS:
    Ten triterpenes (1-10) were isolated and identified from the twigs of Gardenia saxatilis (Rubiaceae) and were subjected to antiplasmodial evaluation against the parasite Plasmodium falciparum. The first six compounds, lupenone (1), lupeol (2), betulinic acid (3), oleanolic acid (4), ursolic acid (5), and winchic acid (27-O-feruloyloxybetulinic acid) (6) were inactive in the assay. The other four compounds, messagenic acid A (7) and messagenic acid B (8), the 27-O-p-(Z)- and 27-O-p-(E)-coumarate esters of betulinic acid, and a mixture of Uncarinic acid E (27-O-p-(E)-coumaroyloxyoleanolic acid) (9) and 27-O-p-(E)-coumaroyloxyursolic acid (10) exhibited antiplasmodial activity, with the IC50 values of 1.5, 3.8 and 2.9 microg/ml, respectively.
    CONCLUSIONS:
    The results indicated that the p-coumarate moieties at the 27-position, both the cis and trans isomers, contributed to antiplasmodial activity. Introduction of a methoxyl group to the 3-position of the p-coumarate moiety to give a ferulate moiety resulted in loss of activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6159 mL 8.0796 mL 16.1593 mL 32.3185 mL 40.3982 mL
    5 mM 0.3232 mL 1.6159 mL 3.2319 mL 6.4637 mL 8.0796 mL
    10 mM 0.1616 mL 0.808 mL 1.6159 mL 3.2319 mL 4.0398 mL
    50 mM 0.0323 mL 0.1616 mL 0.3232 mL 0.6464 mL 0.808 mL
    100 mM 0.0162 mL 0.0808 mL 0.1616 mL 0.3232 mL 0.404 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    蜡果杨梅酸B; Myriceric acid B CFN98931 55497-79-5 C39H54O7 = 634.9 5mg QQ客服:2159513211
    蜡果杨梅酸C; Myriceric acid C CFN99683 162059-94-1 C48H60O10 = 797.0 5mg QQ客服:1457312923
    苏门树脂酸; Sumaresinolic acid CFN91480 559-64-8 C30H48O4 = 472.7 20mg QQ客服:1457312923
    雷公藤酚C; Wilforol C CFN99802 168254-95-3 C30H48O4 = 472.7 5mg QQ客服:3257982914
    常春藤皂苷元; Hederagenin CFN98695 465-99-6 C30H48O4 = 472.7 20mg QQ客服:3257982914
    (Z)-23-香豆酰常春藤皂苷元; (Z)-23-Coumaroylhederagenin CFN92845 654678-61-2 C39H54O6 = 618.4 5mg QQ客服:2159513211
    23-羟基-3-氧代齐墩果-12-烯-28-酸; Hederagonic acid CFN98696 466-01-3 C30H46O4 = 470.7 5mg QQ客服:1457312923
    钩藤甙元C; Uncargenin C CFN99636 152243-70-4 C30H48O5 = 488.7 5mg QQ客服:1457312923
    3-羟基-12-齐墩果烯-23,28-二酸; 3-Hydroxy-12-oleanene-23,28-dioic acid CFN98227 226562-47-6 C30H46O5 = 486.7 5mg QQ客服:3257982914
    钩藤酸E; Uncarinic acid E CFN96468 277751-61-8 C39H54O6 = 618.84 5mg QQ客服:215959384

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